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Shen, Tao,Li, Wei,Wang, Yan-Yan,Zhong, Qing-Qing,Wang, Shu-Qi,Wang, Xiao-Ning,Ren, Dong-Mei,Lou, Hong-Xiang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
In our cell based screening of antitumor ingredients from plants, the EtOH extract of Garcinia bracteata displayed antiproliferative effect against human lung adenocarcinoma A549 cells, human breast cancer MCF-7 cells, and human prostate cancer PC3 cells. Phytochemical investigation of this active extract produced nine ingredients, and their structures were established by analysis of MS and NMR spectra. Antiproliferative evaluation of isolated ingredients on A549, MCF-7 and PC3 cells indicated that a xanthone named isobractatin (1) exhibited potent antiproliferative activity against the above three human cancer cell lines with $IC_{50}$ values ranging from 2.90 to $4.15{\mu}M$. Treatment of PC3 cells with 1 led to an enhancement of the cell apoptosis, and arrested cell cycle in the G0/G1 phase. The G0/G1 phase cycle-related proteins analysis showed that the expressions of cyclins D1 and E were reduced by 1, whereas the protein level of cyclin dependent kinase (CDK) inhibitor P21 was induced. Additionally, 1 enhanced PC3 cell apoptosis by activations of Bax, caspases 3 and 9, and by inhibition of Bcl-2. Our combined data illustrated that isobractatin (1) was the antiproliferative ingredient of G. bracteata against three human cancer cell lines, which exerted its antiproliferatrive effect via cell cycle arrest and induction of apoptosis.
Shen, Jian-Qing,Yuan, Lei,Chen, Ming-Liang,Xie, Zhen The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.5
A novel equivalent flux sliding-mode observer (SMO) is proposed for dual three-phase interior permanent magnet synchronous motor (DT-IPMSM) drive system in this paper. The DT-IPMSM has two sets of Y-connected stator three-phase windings spatially shifted by 30 electrical degrees. In this method, the sensorless drive system employs a flux SMO with soft phase-locked loop method for rotor speed and position estimation, not only are low-pass filter and phase compensation module eliminated, but also estimation accuracy is improved. Meanwhile, to get the regulator parameters of current control, the inner current loop is realized using a decoupling and diagonal internal model control algorithm. Experiment results of 2MW-level DT-IPMSM drives system show that the proposed method has good dynamic and static performances.
Qing-Li Yang,Ji-Qing Shen,Yan Xue,Xiao-Bing Cheng,Zhi-Hua Jiang,Yi-Chao Yang,Ying-Dan Chen,Xiao-Nong Zhou 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.6
The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.
Tao Shen,Wei Li,Yan-Yan Wang,Qing-Qing Zhong,Shu-Qi Wang,Xiao-Ning Wang,Dong-Mei Ren,Hongxiang Lou 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
In our cell based screening of antitumoringredients from plants, the EtOH extract of Garciniabracteata displayed antiproliferative effect against humanlung adenocarcinoma A549 cells, human breast cancerMCF-7 cells, and human prostate cancer PC3 cells. Phytochemicalinvestigation of this active extract producednine ingredients, and their structures were established byanalysis of MS and NMR spectra. Antiproliferative evaluationof isolated ingredients on A549, MCF-7 and PC3cells indicated that a xanthone named isobractatin (1)exhibited potent antiproliferative activity against the abovethree human cancer cell lines with IC50 values rangingfrom 2.90 to 4.15 lM. Treatment of PC3 cells with 1 led toan enhancement of the cell apoptosis, and arrested cellcycle in the G0/G1 phase. The G0/G1 phase cycle-relatedproteins analysis showed that the expressions of cyclins D1and E were reduced by 1, whereas the protein level of cyclin dependent kinase (CDK) inhibitor P21 was induced. Additionally, 1 enhanced PC3 cell apoptosis by activationsof Bax, caspases 3 and 9, and by inhibition of Bcl-2. Ourcombined data illustrated that isobractatin (1) was theantiproliferative ingredient of G. bracteata against threehuman cancer cell lines, which exerted its antiproliferatriveeffect via cell cycle arrest and induction of apoptosis.
Jian-Qing Shen,Lei Yuan,Ming-Liang Chen,Zhen Xie 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.5
A novel equivalent flux sliding-mode observer (SMO) is proposed for dual three-phase interior permanent magnet synchronous motor (DT-IPMSM) drive system in this paper. The DTIPMSM has two sets of Y-connected stator three-phase windings spatially shifted by 30 electrical degrees. In this method, the sensorless drive system employs a flux SMO with soft phase-locked loop method for rotor speed and position estimation, not only are low-pass filter and phase compensation module eliminated, but also estimation accuracy is improved. Meanwhile, to get the regulator parameters of current control, the inner current loop is realized using a decoupling and diagonal internal model control algorithm. Experiment results of 2MW-level DT-IPMSM drives system show that the proposed method has good dynamic and static performances.
Hybrid CSA optimization with seasonal RVR in traffic flow forecasting
( Zhangguo Shen ),( Wanliang Wang ),( Qing Shen ),( Zechao Li ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.10
Accurate traffic flow forecasting is critical to the development and implementation of city intelligent transportation systems. Therefore, it is one of the most important components in the research of urban traffic scheduling. However, traffic flow forecasting involves a rather complex nonlinear data pattern, particularly during workday peak periods, and a lot of research has shown that traffic flow data reveals a seasonal trend. This paper proposes a new traffic flow forecasting model that combines seasonal relevance vector regression with the hybrid chaotic simulated annealing method (SRVRCSA). Additionally, a numerical example of traffic flow data from The Transportation Data Research Laboratory is used to elucidate the forecasting performance of the proposed SRVRCSA model. The forecasting results indicate that the proposed model yields more accurate forecasting results than the seasonal auto regressive integrated moving average (SARIMA), the double seasonal Holt-Winters exponential smoothing (DSHWES), and the relevance vector regression with hybrid Chaotic Simulated Annealing method (RVRCSA) models. The forecasting performance of RVRCSA with different kernel functions is also studied.
Li, Qing-Qing,Lu, Zhi-Hao,Yang, Li,Lu, Ming,Zhang, Xiao-Tian,Li, Jian,Zhou, Jun,Wang, Xi-Cheng,Gong, Ji-Fang,Gao, Jing,Li, Jie,Li, Yan,Shen, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR, GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.
심경리 ( Qing Li Shen ) 고려대학교 중국학연구소 2008 中國學論叢 Vol.23 No.-
China belongs to the `the oriental world`, and she had close relation with these nations such as Indian, Japan and Korea. Some modem Chinese writers created a series of fictions depicted Korean resisting Japanese aggression, which manifested the deep feelings between the two nations. In general, more writers in modem China described these countries as draggling and barbarian land; on the other hand, some writers regarded them as the narrative background of romantic exotic theme, which revealed certain complex of ethnocentrism.
Zhang, Qing-Mei,Shen, Ning,Xie, Sha,Bi, Shui-Qing,Luo, Bin,Lin, Yong-Da,Fu, Jun,Zhou, Su-Fang,Luo, Guo-Rong,Xie, Xiao-Xun,Xiao, Shao-Wen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Melanoma-associated antigen (MAGE) family genes have been considered as potentially promising targets for anticancer immunotherapy. MAGED4 was originally identified as a glioma-specific antigen. Current knowledge about MAGED4 expression in glioma is only based on mRNA analysis and MAGED4 protein expression has not been elucidated. In the present study, we investigated this point and found that MAGED4 mRNA and protein were absent or very lowly expressed in various normal tissues and glioma cell line SHG44, but overexpressed in glioma cell lines A172,U251,U87-MG as well as glioma tissues, with significant heterogeneity. Furthermore, MAGED4 protein expression was positively correlated with the glioma type and grade. We also found that the expression of MAGED4 inversely correlated with the overall methylation status of the MAGED4 promoter CpG island. Furthermore, when SHG44 and A172 with higher methylation were treated with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-AZA-CdR) reactivation of MAGED4 mRNA was mediated by significant demethylation in SHG44 instead of A172. However, 5-AZA-CdR treatment had no effect on MAGED4 protein in both SHG44 and A172 cells. In conclusion, MAGED4 is frequently and highly expressed in glioma and is partly regulated by DNA methylation. The results suggest that MAGED4 might be a promising target for glioma immunotherapy combined with 5-AZA-CdR to enhance its expression and eliminate intratumor heterogeneity.