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CARMA LARGE AREA STAR FORMATION SURVEY: DENSE GAS IN THE YOUNG L1451 REGION OF PERSEUS
Storm, Shaye,Mundy, Lee G.,Lee, Katherine I.,Ferná,ndez-Ló,pez, Manuel,Looney, Leslie W.,Teuben, Peter,Arce, Hé,ctor G.,Rosolowsky, Erik W.,Meisner, Aaron M.,Isella, Andrea,Kauffmann American Astronomical Society 2016 The Astrophysical journal Vol.830 No.2
<P>We present a 3 mm spectral line and continuum survey of L1451 in the Perseus Molecular Cloud. These observations are from the CARMA Large Area Star Formation Survey (CLASSy), which also imaged Barnard. 1, NGC 1333, Serpens Main, and Serpens South. L1451 is the survey region with the lowest level of star formation activity-it contains no confirmed protostars. HCO+, HCN, and N2H+ (J = 1 -> 0). are all detected throughout the region, with HCO+ being the most spatially widespread, and molecular emission seen toward 90% of the area above N(H-2) column densities of 1.9 x 10(21) cm(-2). HCO+ has the broadest velocity dispersion, near 0.3 km s(-1) on average, compared with similar to 0.15 km s(-1) for the other molecules, thus representing a range of subsonic to supersonic gas motions. Our non-binary dendrogram analysis reveals that the dense gas traced by each molecule has a similar hierarchical structure, and that gas surrounding the candidate first hydrostatic core (FHSC), L1451-mm, and other previously detected single-dish continuum clumps has similar hierarchical structure; this suggests that different subregions of L1451 are fragmenting on the pathway to forming young stars. We determined that the three-dimensional morphology of the largest detectable dense-gas structures was relatively ellipsoidal compared with other CLASSy regions, which appeared more flattened at the largest scales. A virial analysis shows that the most centrally condensed dust structures are likely unstable against collapse. Additionally, we identify a new spherical, centrally condensed N2H+ feature that could be a new FHSC candidate. The overall results suggest that L1451 is a young region starting to form its generation of stars within turbulent, hierarchical structures.</P>
Rebecca C. Shay,Jennifer R. Diamond,Jodi A. Kagihara,Sharon B. Sams 한국유방암학회 2021 Journal of breast cancer Vol.24 No.1
Paraneoplastic neurologic diseases (PND) are rare but can occur in patients with common malignancies including breast cancer. In patients with hormone receptor (HR)-negative human epidermal growth factor receptor 2 (HER2)-positive breast cancer, PND have been reported in association with anti-Yo antibodies and with clinical presentation of paraneoplastic cerebellar degeneration. We describe the case of a woman with progressively altered mental status and seizures, ultimately requiring admission. Based on her clinical presentation, imaging findings, and evidence of neural-directed antibodies in her serum and cerebrospinal fluid, she was diagnosed with paraneoplastic limbic encephalitis (LE) due to an underlying HR-negative, HER2-positive breast cancer. She showed a transient response to immunosuppression but had more significant improvement after surgical resection and initiation of chemotherapy along with HER2-directed therapy. To the best of our knowledge, this is the first documented case of paraneoplastic LE in a patient with HR-negative, HER2-positive breast cancer likely caused by the production of an unclassified anti-neuronal antibody.
Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro
전소영,Shay Soker,장유진,권태균,유은상 대한의학회 2016 Journal of Korean medical science Vol.31 No.2
We investigated the potential of human dental pulp stem cells (hDPSCs) to differentiate into dopaminergic neurons in vitro as an autologous stem cell source for Parkinson’s disease treatment. The hDPSCs were expanded in knockout-embryonic stem cell (KO-ES) medium containing leukemia inhibitory factor (LIF) on gelatin-coated plates for 3-4 days. Then, the medium was replaced with KO-ES medium without LIF to allow the formation of the neurosphere for 4 days. The neurosphere was transferred into ITS medium, containing ITS (human insulin-transferrin-sodium) and fibronectin, to select for Nestin-positive cells for 6-8 days. The cells were then cultured in N-2 medium containing basic fibroblast growth factor (FGF), FGF-8b, sonic hedgehog-N, and ascorbic acid on poly-L-ornithine/ fibronectin-coated plates to expand the Nestin-positive cells for up to 2 weeks. Finally, the cells were transferred into N-2/ascorbic acid medium to allow for their differentiation into dopaminergic neurons for 10-15 days. The differentiation stages were confirmed by morphological, immunocytochemical, flow cytometric, real-time PCR, and ELISA analyses. The expressions of mesenchymal stem cell markers were observed at the early stages. The expressions of early neuronal markers were maintained throughout the differentiation stages. The mature neural markers showed increased expression from stage 3 onwards. The percentage of cells positive for tyrosine hydroxylase was 14.49%, and the amount was 0.526 ± 0.033 ng/mL at the last stage. hDPSCs can differentiate into dopaminergic neural cells under experimental cell differentiation conditions, showing potential as an autologous cell source for the treatment of Parkinson’s disease.
Relation between cuprate superconductivity and magnetism: A Raman study of(CaLa)1(BaLa)2Cu3Oy
Wulferding, Dirk,Shay, Meni,Drachuck, Gil,Ofer, Rinat,Bazalitsky, Galina,Salman, Zaher,Lemmens, Peter,Keren, Amit American Physical Society 2014 Physical review. B, Condensed matter and materials Vol.90 No.10