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Chun-Yeung Lo,Sze-Ting Choi,Olive Tin-Wai Li,Jacky Chi-Ki Ngo,David Chi-Cheong Wan,Leo Lit-Man Poon,Pang-Chui Shaw1 한국구조생물학회 2015 Biodesign Vol.3 No.3
Currently, many strains of influenza A virus have developed resistance against anti-influenza drugs, and it is essential to find new chemicals to combat this virus. The viral nucleoprotein (NP) is a major component of the ribonucleoprotein (RNP) complex for the transcription and replication of the virus. In this study, we have employed surface plasmon resonance direct binding screening on the influenza A NP and found a hit compound 16 that can subdue influenza RNP activities. Subsequently, two analogs (compounds 55 & 58) from compound 16 were identified which inhibit RNP activities of various influenza A subtypes and viral growth at micromolar levels. These analogs were also shown to directly interact with NP, with KD 12.0±1.25 and 41.6±1.93 μM respectively by surface plasmon resonance assay.
Shaw Meredith 동아시아연구원 2022 Journal of East Asian Studies Vol.22 No.2
South Korea's persistent enmity towards its erstwhile colonizer Japan has been a compelling topic of East Asian international relations scholarship for decades. This article argues that the historical evolution of South Korea's democracy offers a vital and overlooked piece of this puzzle. Given that it emerged from one of the most virulently anti-communist dictatorships of the Cold War period, in a society facing an ongoing threat from communist North Korea, any left-of-center opposition movement faced an uphill battle against severe anti-communism. In such circumstances, the only way for a leftist opposition party to survive was by pitting its stronger anti-Japan reputation against conservatives’ anti-communism. After South Korea's democracy stabilized, liberals tried and failed to overturn the anti-leftist institutions left over from the Cold War and then sought equilibrium through parallel rhetoric targeting pro-Japanese elements. Today, neither left nor right can afford to allow a final amicable settlement with its respective target of antagonism. Through analyses of domestic political rhetoric targeting alleged pro-Japanese or pro-communist elements, this paper demonstrates how these competing antagonisms achieved an uneasy equilibrium that undergirds South Korean political dynamics to this day.
Shaw, Ian D.,Andrawes, Bassem Techno-Press 2017 Advances in computational design Vol.2 No.2
Over the past couple decades, externally bonded fiber reinforced polymer (FRP) composites have emerged as a repair and strengthening material for many concrete infrastructure applications. This paper presents an analytical investigation of the use of carbon FRP (CFRP) for a specific problem that occurs in concrete bridge girders wherein the girder ends are damaged by excessive exposure to deicing salts and numerous freezing/thawing cycles. A 3D finite element (FE) model of a full scale prestressed concrete (PC) I-girder is used to investigate the effect of damage to the cover concrete and stirrups in the end region of the girder. Parametric studies are performed using externally bonded CFRP shear laminates to determine the most effective repair schemes for the damaged end region under a short shear span-to-depth ratio. Experimental results on shear pull off tests of CFRP laminates that have undergone accelerated aging are used to calibrate a bond stress-slip model for the interface between the FRP and concrete substrate and approximate the reduced bond stress-slip properties associated with exposure to the environment that causes this type of end region damage. The results of these analyses indicate that this particular application of this material can be effective in recovering the original strength of PC bridge girders with damaged end regions, even after environmental aging.