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Chun-Yeung Lo,Sze-Ting Choi,Olive Tin-Wai Li,Jacky Chi-Ki Ngo,David Chi-Cheong Wan,Leo Lit-Man Poon,Pang-Chui Shaw1 한국구조생물학회 2015 Biodesign Vol.3 No.3
Currently, many strains of influenza A virus have developed resistance against anti-influenza drugs, and it is essential to find new chemicals to combat this virus. The viral nucleoprotein (NP) is a major component of the ribonucleoprotein (RNP) complex for the transcription and replication of the virus. In this study, we have employed surface plasmon resonance direct binding screening on the influenza A NP and found a hit compound 16 that can subdue influenza RNP activities. Subsequently, two analogs (compounds 55 & 58) from compound 16 were identified which inhibit RNP activities of various influenza A subtypes and viral growth at micromolar levels. These analogs were also shown to directly interact with NP, with KD 12.0±1.25 and 41.6±1.93 μM respectively by surface plasmon resonance assay.
Shaw, Ping-Shine,Arp, Uwe,Saunders, Robert D.,Shin, Dong-Joo,Yoon, Howard W.,Gibson, Charles E.,Li, Zhigang,Parr, Albert C.,Lykke, Keith R. The Optical Society 2007 Applied optics Vol.46 No.1
<P>A new facility for measuring irradiance in the UV was commissioned recently at the National Institute of Standards and Technology (NIST). The facility uses the calculable radiation from the Synchrotron Ultraviolet Radiation Facility as the primary standard. To measure the irradiance from a source under test, an integrating sphere spectrometer-detector system measures both the source under test and the synchrotron radiation sequentially, and the irradiance from the source under test can be determined. In particular, we discuss the calibration of deuterium lamps using this facility from 200 to 400 nm. This facility improves the current NIST UV irradiance scale to a relative measurement uncertainty of 1.2% (k=2).</P>
Shaw Meredith 동아시아연구원 2022 Journal of East Asian Studies Vol.22 No.2
South Korea's persistent enmity towards its erstwhile colonizer Japan has been a compelling topic of East Asian international relations scholarship for decades. This article argues that the historical evolution of South Korea's democracy offers a vital and overlooked piece of this puzzle. Given that it emerged from one of the most virulently anti-communist dictatorships of the Cold War period, in a society facing an ongoing threat from communist North Korea, any left-of-center opposition movement faced an uphill battle against severe anti-communism. In such circumstances, the only way for a leftist opposition party to survive was by pitting its stronger anti-Japan reputation against conservatives’ anti-communism. After South Korea's democracy stabilized, liberals tried and failed to overturn the anti-leftist institutions left over from the Cold War and then sought equilibrium through parallel rhetoric targeting pro-Japanese elements. Today, neither left nor right can afford to allow a final amicable settlement with its respective target of antagonism. Through analyses of domestic political rhetoric targeting alleged pro-Japanese or pro-communist elements, this paper demonstrates how these competing antagonisms achieved an uneasy equilibrium that undergirds South Korean political dynamics to this day.