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- 저자 : Shaojuan Hao (검색결과 3 건)
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Shaojuan GU,Yu Liu,Xiaohong Zi,Hao Deng 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.1
Background Vogt-Koyanagi-Harada (VKH) disease is characterized by bilateral granulomatous uveitis with neurologic, auditory, and dermatologic manifestations. However, acute myelitis complicating VKH disease has rarely been reported. Case Report A 50-year-old Chinese Han woman presented with difficulty walking, numbness on the left side of the body, and difficulty with urination. The patient was diagnosed with incomplete VKH disease and received corticosteroid treatment prior to the neurological presentation. Acute myelitis was diagnosed based on both clinical and spinal-cord MRI findings. Conclusions Clinicians should consider acute myelitis as a rare possible neurological manifestation in VKH disease patients, and early systemic administration of corticosteroids will suppress the acute inflammatory process and prevent recurrences. This report raises the possibility that VKH disease and acute myelitis share common pathogenic pathways
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Catalytic upgrading of chitin: Advances, mechanistic insights, and prospect
Hao Huang,Guangping Zhou,Shaojuan Luo,Shaoqu Xie 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
The most plentiful renewable nitrogenous material on earth is chitin, which may be obtained from theshell waste of crustaceans. This waste is not fully utilized, resulting in resource waste and disposal problems. Due to the enormous potential of chitin pricing, a novel idea for shell biorefining has recently beenput forth. Several valuable chemicals have been produced from chitin biomass, including small-moleculecompounds, prodrugs, and monomers of polymers. This paper reviews the recent progress in the catalyticconversion of chitin, chitosan, and their derivatives to various chemicals and biomaterials. The selectionand properties of catalysts and catalytic systems were introduced. The mechanism of transformation ormodification is emphasized. The challenges and prospects of chitin transformation and modification arepresented.
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Xiaodan Zhu,Fanglei Ye,Shaojuan Hao,Qiuning Yu,Yang Wang,Weihua Lou,Kun Zhao,Hongmin Li 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.1
Cholesteatoma is a pathologically benign but clinically destructive middle ear disease characterized by hyperproliferative keratinocytes. B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) has been reported to be upregulated in cholesteatoma tissues. This study aimed to explore the biological role and underlying mechanisms of BMI1 in the progression of cholesteatoma. The expression levels of microRNA (miR)-1297, miR-26a- 5p, and BMI1 in cholesteatoma tissues and cells were examined by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Functional experiments were performed by CCK-8 assay for cell proliferation viability, 5-ethynyl-2'deoxyuridine (EdU) incorporation assay for DNA biosynthesis, colony formation assay for cloning forming ability analysis, transwell assay and wound healing assay for cell metastasis, flow cytometry for cell cycle distribution and cell apoptosis. The protein expression of apoptosis-associated proteins was investigated by western blot. Dual-luciferase reporter assay was conducted to verify the interaction between miR-1297 or miR-26a-5p and BMI1. BMI1 was highly expressed in cholesteatoma tumor tissues. Functional analyses showed that BMI1 knockdown could inhibit the proliferation, colony formation, migration, invasion, cell cycle progression and promoted the apoptosis of keratinocytes. Mechanically, BMI1 was a target of miR-1297 and miR-26a-5p. Moreover, the rescue experiments presented that BMI1 addition could abolish the suppressive effects of miR-1297 or miR-26a-5p overexpression on cell malignant behaviors in keratinocytes. BMI1 could exert an oncogenic role in the malignant development of cholesteatoma through serving as the targets of miR-1297 and miR-26a-5p, which might provide novel strategies for cholesteatoma treatment.
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