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한국인의 2중합효소연쇄반응-증폭 좌위에 대한 동위 유전자 빈도 분포
홍경자,백승연,채영규 한양대학교 이학기술연구소 2000 이학기술연구지 Vol.2 No.
Tetranucleotide STR인 HUMTH01과 HUMF13A1에 대한 대립형질과 유전형질 빈도를 한국인을 대상으로 전기영동 및 중합효소연쇄반응을 이용하여 분석하였다. HUMTH01과 HUMF13A1 유전형질 분포 양상은 Hardy-Weinberg 공식을 따랐다. 부가적으로 한국인 집단의 대립형질 빈도를 중국인과 유럽코커시안 집단의 데이터와 비교하였다. 코커시안집단에서 HUMTH01의 분포양상은 유사하였다. 하지만 한국인과 중국인 집단의 결과와 유사하였다. 본 연구에서 HUMTH01과 HUMF13A1 STR 좌위에 대한 한국인 집단 데이터베이스를 확립하였다. 이들 집단에서 STR의 대립형질빈도 분포 데이터는 인간집단유전학을 위한 연구에 유용하게 사용될 수 있을 것이다. Allele and genotype frequencies for the tetranucleotide STRs (short tandem repeats) of HUMTH01 and HUMF13A1 were investigated in Korean population using electrophoresis and PCR amplification. The HUMTH01 and the HUMF13A1 genotype distributions were in Hardy-Weinberg equilibrium. Additionary, the allele frequencies of Korean population were compared with data for the Chinese population and European Caucasian populations. There were similar distribution patterns of HUMTH01 allete frequencies among the Caucasian populations. However, Korean and Chinese populations were significantly different with them. Allele distribution pattern of Korean was more similar with Chinese population than them of European. Conclusively, the Korean population database has been established for HUMTH01 and HUMF13A1 STR loci. These data of allele frequencies distribution of STRs in population will be useful for studies on human population genetics.
강윤선 ( Youn-sun Kang ),김소희 ( So-hee Kim ),채승기 ( Seung-gi Chai ) 한국정보처리학회 2010 한국정보처리학회 학술대회논문집 Vol.17 No.2
정부기관의 대민서비스 제공 관점이 수요자 중심으로 전환되고 대국민 만족도 측면의 중요성이 강조되면서 정부기관 콜센터의 운영 및 서비스에 대한 표준화된 품질 평가에 대한 고려가 필요하게 되었다. 본 논문에서는 정부기관 콜센터 품질 평가 기준을 운영체계·운영서비스·운영성과 관점에서 제시하여, 정부기관 콜센터의 운영효율성 제고, 상담서비스 품질 확보 및 대국민 만족도를 향상하기 위한 평가 프레임워크를 제시하고자 한다.
Investigation of bone formation using calcium phosphate glass cement in beagle dogs
Lee, Seung-Bum,Jung, Ui-Won,Choi, Youn-A,Jamiyandorj, Otgonbold,Kim, Chang-Sung,Lee, Yong-Keun,Chai, Jung-Kiu,Choi, Seong-Ho Korean Academy of Periodontology 2010 Journal of Periodontal & Implant Science Vol.40 No.3
Purpose: Among available biomaterials, bioceramics have drawn special interest due to their bioactivity and the possibility of tailoring their composition. The degradation rate and formulation of bioceramics can be altered to mimic the compositions of the mineral phase of bone. The aim of this study was to investigate the bone formation effect of amorphous calcium phosphate glass cement (CPGC) synthesized by a melting and quenching process. Methods: In five male beagle dogs, $4{\times}4$ mm 1-wall intrabony defects were created bilaterally at the mesial or distal aspect of the mandibular second and fourth premolars. Each of the four defects was divided according to graft materials: CPGC with collagen membrane (CM), biphasic calcium phosphate (BCP) with CM, CM alone, or a surgical flap operation only. The dogs were sacrificed 8 weeks post-surgery, and block sections of the defects were collected for histologic and histometric analysis. Results: There were significant differences in bone formation and cementum regeneration between the experimental and control groups. In particular, the CPGC and BCP groups showed greater bone formation than the CM and control groups. Conclusions: In conclusion, CPGC was replaced rapidly with an abundant volume of new bone; CPGC also contributed slightly to regeneration of the periodontal apparatus.
Gender Differences in Neural Responses to Perceptually Invisible Fearful Face—An ERP Study
Lee, Seung A.,Kim, Chai-Youn,Shim, Miseon,Lee, Seung-Hwan Frontiers Media S.A. 2017 Frontiers in Behavioral Neuroscience Vol.11 No.-
<P>Women tend to respond to emotional stimuli differently from men. This study aimed at investigating whether neural responses to perceptually “invisible” emotional stimuli differ between men and women by exploiting event-related potential (ERP). Forty healthy participants (21 women) were recruited for the main experiment. A control experiment was conducted by excluding nine (7 women) participants from the main experiment and replacing them with additional ten (6 women) participants (total 41 participants) where Beck's Anxiety Inventory (BAI) and Beck's Depression Inventory (BDI) scores were controlled. Using the visual backward masking paradigm, either a fearful or a neutral face stimulus was presented in varied durations (subthreshold, near-threshold, or suprathreshold) followed by a mask. Participants performed a two-alternative forced choice (2-AFC) emotion discrimination task on each face. Behavioral analysis showed that participants were unaware of masked stimuli of which duration was the shortest and, therefore, processed at subthreshold. Nevertheless, women showed significantly larger response in P100 amplitude to subthreshold fearful faces than men. This result remained consistent in the control experiment. Our findings indicate gender-differences in neural response to subthreshold emotional face, which is reflected in the early processing stage.</P>