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Lee, Eun-Jae,Kim, Jong S.,Chang, Dae-Il,Park, Jong-Ho,Ahn, Seong Hwan,Cha, Jae-Kwan,Heo, Ji Hoe,Sohn, Sung-Il,Lee, Byung-Chul,Kim, Dong-Eog,Kim, Hahn Young,Kim, Seongheon,Kwon, Do-Young,Kim, Jei,Seo, Korean Stroke Society 2018 Journal of stroke Vol.20 No.2
<P><B>Background and Purpose</B></P><P> The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual’s mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. </P><P><B>Methods</B></P><P> This study involved a <I>post hoc</I> analysis of data from EMOTION (ClinicalTrials.gov NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke. Participants were classified into the Baseline-Blue (patients with baseline depression at the time of randomization, defined per the Montgomery-Asberg Depression Rating Scale [MADRS] ≥8) or the Baseline-Pink groups (patients without baseline depression). We compared the efficacy of escitalopram and predictors of 3-month PSD (MADRS ≥8) between these groups. </P><P><B>Results</B></P><P> There were 203 Baseline-Pink and 275 Baseline-Blue patients. The efficacy of escitalopram in reducing PSD risk was more pronounced in the Baseline-Pink than in the Baseline-Blue group (<I>p</I> for interaction=0.058). Several risk factors differentially affected PSD development based on the presence of baseline depression (<I>p</I> for interaction <0.10). Cognitive dysfunction was an independent predictor of PSD in the Baseline-Blue, but not in the Baseline-Pink group, whereas the non-use of escitalopram and being female were more strongly associated with PSD in the Baseline-Pink group. </P><P><B>Conclusions</B></P><P> Responses to escitalopram and predictors of PSD 3 months following stroke differed based on the presence of baseline depression. Our data suggest that PSD pathophysiology is heterogeneous; therefore, different therapeutic strategies may be needed to prevent PSD emergence following stroke.</P>
Lee, Jee Young,Choi, SeongHeon,Park, Sora,Lee, Sung Un,Lee, Soomin,Jung, Yeehong The Society of Korean Medicine 2014 대한한의학회지 Vol.35 No.4
Objectives: Rectal cancer bleeding occurs approximately 20% of overall rectal cancer patients. The current standard treatments cannot cover minor bleeding enough. Failures of the local or systemic approaches to stop bleeding are frequently reported. Methods: we reported a case of male rectal cancer patient who was treated with herbal decoction and significantly improved on symptoms, such as, loose stools and rectal bleeding. Previous to first visiting to our clinic, he was prescribed to use oral tranexamic acids, which failed to relieve his symptoms. He was administered with an herbal decoction, Inhyungtang, clinically known to have hemostastic effect in hematochezia. Results & Conclusion: The prescription showed significant improvement on his symptom, in particular, his bleeding. Thus, we report his case and we expect further experiences and experimental studies to support efficacy of Inhyungtang.
Modified Algorithm of Predictive Ground Collision Avoidance System for the Low Level Terrain Flight
Seongheon Lee,Dongjin Lee,Hyochoong Bang 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
Controlled Flight Into Terrain (CFIT) is reported as a major cause of today’s aircraft accidents. To mitigate these accidents, Predictive Ground Collision Avoidance System (PGCAS) has been used since the mid-70s. In PGCAS algorithm, however, relatively large safety margin for the terrain searching pattern could cause some drawbacks such as nuisance alarms or unnecessary pull-up commands during a tactical terrain-following or low level terrain flight to evade enemy’s air defense network. In this paper, a modified algorithm based on weighted terrain searching pattern is proposed to improve PGCAS more efficiently for the low level terrain flight. The weighted terrain searching pattern reflects the aircraft’s performance and the flight path to give more reasonable safety margin to the system. The terrain elevation data lying on the exterior of the terrain searching pattern are set to give lower terrain elevation than the data on the interior. The proposed algorithm is further analyzed through simulations to evaluate its performance.
Hyunjung Lee,Cheolhun Choi,Cheolhun Choi,Hyejin Jeong,Seongheon Lee,Seongwook Jeong 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.64 No.1
Background: Although cisatracurium has many advantages in anesthetic practices, the best choice of a nondepolarizing neuromuscular blocking agent that can replace succinylcholine is rocuronium. However, it is reported that remifentanil with propofol might provide reliable intubating condition, even without a neuromuscular blocking agent; therefore, it might improve the intubating condition with cisatracurium. This study examined intubating conditions after administering rocuronium or cisatracurium in a rapid sequence induction with remifentanil-propofol. Methods: Fifty two ASA physical status 1 or 2 adult patients scheduled for an elective surgery were enrolled in a randomized double-blinded trial. Anesthesia was induced in all patients with propofol 2.0 mg/kg and remifentanil 0.5 μg/kg, administered over 60 seconds. Rocuronium 0.9 mg/kg (3 × ED95, R group, n = 23) or cisatracurium 0.15 mg/kg (3 × ED95, C group, n = 29) was administered after the induction sequence. Laryngoscopy was attempted when the anesthesiologist thought it was 90 seconds after drug administration and appropriate time for intubation. The examiner, another anesthesiologist, recorded the exact time to intubation and suppression of maximal T1 on TOF. The intubating condition was assessed by the first anesthesiologist, as excellent, good, poor or not possible. Results: The best time to laryngoscopy was predicted by measuring TOF and was found to be significantly longer in the C group (197 ± 53 s) than in the R group (102 ± 49 s) (P value < 0.05). However, time to larygoscopy, intubating condition during the laryngoscopy, and hemodynamic changes after intubation was similar in both groups. Conclusions: Despite fundamentally slower onset time, cisatracurium can provide quite good intubating conditions, which were comparable to those achieved with equipotent doses of rocuronium, which is more expensive in anesthesia inducted with remifentanil and propofol.
순차적 칼만 필터를 적용한 다중센서 위치추정 알고리즘의 실험적 검증
이성헌(Seongheon Lee),김영주(Youngjoo Kim),방효충(Hyochoong Bang) 제어로봇시스템학회 2015 제어·로봇·시스템학회 논문지 Vol.21 No.1
Unmanned air vehicles (UAVs) are getting popular not only as a private usage for the aerial photograph but military usage for the surveillance, reconnaissance and supply missions. For an UAV to successfully achieve these kind of missions, geolocation (localization) must be implied to track an interested target or fly by reference. In this research, we adopted multi-sensor fusion (MSF) algorithm to increase the accuracy of the geolocation and verified the algorithm using two multicopter UAVs. One UAV is equipped with an optical camera, and another UAV is equipped with an optical camera and a laser range finder. Throughout the experiment, we have obtained measurements about a fixed ground target and estimated the target position by a series of coordinate transformations and sequential Kalman filter. The result showed that the MSF has better performance in estimating target location than the case of using single sensor. Moreover, the experimental result implied that multi-sensor geolocation algorithm is able to have further improvements in localization accuracy and feasibility of other complicated applications such as moving target tracking and multiple target tracking.
이성헌(Seongheon Lee),조한진(Hanjin Cho),조영기(Youngki Cho),방효충(Hyochoong Bang) 한국항공우주학회 2015 韓國航空宇宙學會誌 Vol.43 No.3
초소형 스마트탄은 탄도를 수정하여 손쉽게 목표물을 타격할 수 있도록 고안된 개인 휴대용 유도미사일이다. 초소형 스마트탄은 유도미사일에 준하는 기능을 수행하는데 반하여 그 크기가 일반 병사들이 쉽게 휴대할 수 있도록 축소됨으로써 아군의 전력과 생존율을 크게 높일 수 있을 것으로 기대된다. 본 논문에서는 초소형 스마트탄의 탄도수정을 위해 사용된 구동장치를 중심으로 해외에서 선행된 기술개발 사례와 특허들을 수집해 보았다. 이를 바탕으로 초소형 스마트탄의 개발을 위한 소요기술들을 분석해 보고, 추후 개념설계를 위한 초석을 마련하였다. Miniature smart-bullet is a human-carrying guided missile designed to hit a target easily while having a miniature size. Contrary to the normal missiles, miniature smart-bullet is highly expected to enhance the military strength and survival rate of troops by its compact size readily carriable to a single soldier. In this paper, previously developed techniques, activities and patents of miniature smart-bullet, particularly its structural shape and actuators are surveyed. Furthermore, analysis of required techniques to develop a miniature smart-bullet are also discussed for upcoming conceptual design.