웹카메라를 이용한 천체사진촬영에 관한 연구

류성룡,황완기 금오공과대학교 2006 論文集 Vol.27 No.-

Recently, CCD cameras has been widely adoped for astronomical photography. CCD is more sensitive than photographic film and has the advantage of e,ISY digital image processing. In this paper, we have used a PC web camera instead of expensive commercial astronomical CCD camera for astrophotography. The images of the bright objects such as Moon, Sun, and Jupiter have been easily obtained by an ordinary web camera. A Vesta Pro web camera have been modified by Steve Chamber method for long exposed astrophotography. The thermal noise of the CCD has been dramatically decreased by cooling the CCD with a Peltier device. The initial images of the globular clusters M3 and M13 have been obtained with the modified Vesta Pro~SC web camera. We could obtain the bright pictures correspond to the long exposed photography by digitally adding the several short exposed frames. The noise of the long exposed frames were greatly reduced compared to the short exposed frames. In conclusion, we have shown that the web camera can be used for astrophography very economically in middle schools and high schools which have telescopes with limited tracking ability.

Designed Workfunction Engineering of Double-Stacked Metal Nanocrystals for Nonvolatile Memory Application

Seong-Wan Ryu,Jong-Won Lee,Jin-Woo Han,Sungho Kim,Yang-Kyu Choi IEEE 2009 IEEE transactions on electron devices Vol.56 No.3

<P>A double-stacked nanocrystal (DSNC) flash memory is presented for improvement of both program/erase (P/E) speed and data retention time. Four combinations of nickel (Ni) and gold (Au) (Ni/Ni, Au/Au, Ni/Au, and Au/Ni) are used as charge storage DSNC materials and are compared from the perspective of memory performance. Through experimental results for P/E efficiency and retention time, the optimized energy band lineup for faster P/E and longer charge retention is presented. A combination of a deep potential well at the top and a shallow potential well at the bottom exhibits optimized performance in P/E, and this combination also shows the longest data retention characteristics.</P>

Investigation of Isolation-Dielectric Effects of PDSOI FinFET on Capacitorless 1T-DRAM

Seong-Wan Ryu,Jin-Woo Han,Chung-Jin Kim,Yang-Kyu Choi IEEE 2009 IEEE transactions on electron devices Vol.56 No.12

<P>The isolation-dielectric effects of a FinFET structure with a partially depleted (PD) silicon-on-insulator (PDSOI) region as a charge storage node on the characteristics of 1T-DRAM are reported in this brief. By introducing the low-permittivity isolation dielectric as an isolation layer among the active regions, the body potential over the PDSOI region is reduced due to the decreased capacitive coupling between the gate and the PD region; hence, it yields a widened 1T-DRAM sensing margin despite high off-state and low on-state currents. The increased gate height shows the high sensitivity of the sensing margin through the isolation-dielectric permittivity in the PDSOI FinFET 1T-DRAM.</P>

Fullerene-Derivative-Embedded Nanogap Field-Effect-Transistor and Its Nonvolatile Memory Application

Ryu, Seong-Wan,Kim, Chung-Jin,Kim, Sungho,Seo, Myungsoo,Yun, Changhun,Yoo, Seunghyup,Choi, Yang-Kyu WILEY-VCH Verlag 2010 Small Vol.6 No.15

<B>Graphic Abstract</B> <P>A nanogap field-effect transistor with PCBM, a C<SUB>60</SUB> derivative, is demonstrated, and evidence for nanogap filling is provided. The transistor serves as a charge-based detector to identify the imbibitions of the nanoscale capillary channel originating from the high-electron receptivity of the PCBM. In an extended application, a 2-bit-per-cell nonvolatile memory operation is performed, and the transistor is verified as a promising candidate without interference from adjacent memory cells. <img src='wiley_img_2010/16136810-2010-6-15-SMLL200902410-content.gif' alt='wiley_img_2010/16136810-2010-6-15-SMLL200902410-content'> </P>

수족냉증(手足冷症) 환자(患者)에 대(對)한 컴퓨터 적외선(赤外線) 체열촬영(體熱撮影)의 의의(意義)

조유경,오수완,조남희,김동묵,김진성,류봉하,박동원,류기원,Cho, Yu-Kyung,Oh, Su-Wan,Cho, Nam-Hee,Kim, Dong-Mook,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2

To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.

Valproic Acid Downregulates the Expression of MGMT and Sensitizes Temozolomide-Resistant Glioma Cells

Ryu, Chung Heon,Yoon, Wan Soo,Park, Kwang Ywel,Kim, Seong Muk,Lim, Jung Yeon,Woo, Ji Sun,Jeong, Chang Hyun,Hou, Yun,Jeun, Sin-Soo Hindawi Publishing Corporation 2012 Journal of biomedicine & biotechnology Vol.2012 No.-

<P>Temozolomide (TMZ) has become a key therapeutic agent in patients with malignant gliomas; however, its survival benefit remains unsatisfactory. Valproic acid (VPA) has emerged as an anticancer drug via inhibition of histone deacetylases (HDACs), but the therapeutic advantages of a combination with VPA and TMZ remain poorly understood. The main aim of the present study was to determine whether an antitumor effect could be potentiated by a combination of VPA and TMZ, especially in TMZ-resistant cell lines. A combination of VPA and TMZ had a significantly enhanced antitumor effect in TMZ-resistant malignant glioma cells (T98 and U138). This enhanced antitumor effect correlated with VPA-mediated reduced O6-methylguanine-DNA methyltransferase (MGMT) expression, which plays an important role in cellular resistance to alkylating agents. <I>In vitro</I>, the combination of these drugs enhanced the apoptotic and autophagic cell death, as well as suppressed the migratory activities in TMZ-resistant cell lines. Furthermore, <I>in vivo</I> efficacy experiment showed that treatment of combination of VPA and TMZ significantly inhibited tumor growth compared with the monotherapy groups of mice. These results suggest that the clinical efficacy of TMZ chemotherapy in TMZ-resistant malignant glioma may be improved by combination with VPA.</P>

Tristetraprolin Inhibits the Growth of Human Glioma Cells through Downregulation of Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor mRNAs

Ryu, Jinhyun,Yoon, Nal Ae,Lee, Yeon Kyung,Jeong, Joo Yeon,Kang, Seokmin,Seong, Hyemin,Choi, Jungil,Park, Nammi,Kim, Nayoung,Cho, Wha Ja,Paek, Sun Ha,Cho, Gyeong Jae,Choi, Wan Sung,Park, Jae-Yong,Park, Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.2

Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3' untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

Gene therapy of intracranial glioma using interleukin 12-secreting human umbilical cord blood-derived mesenchymal stem cells.

Ryu, Chung Heon,Park, Sang-Hoon,Park, Soon A,Kim, Seong Muk,Lim, Jung Yeon,Jeong, Chang Hyun,Yoon, Wan-Soo,Oh, Won-il,Sung, Young Chul,Jeun, Sin-Soo Mary Ann Liebert 2011 Human gene therapy Vol.22 No.6

<P>Clinical trials of gene therapy using a viral delivery system for glioma have been limited. Recently, gene therapy using stem cells as the vehicles for delivery of therapeutic agents has emerged as a new treatment strategy for malignant brain tumors. In this study, we used human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) as delivery vehicles with glioma-targeting capabilities, and modified interleukin-12 (IL-12p40N220Q; IL-12M) as a novel therapeutic gene. We also engineered UCB-MSCs to secret IL-12M (UCB-MSC-IL12M) via tetrameric cell-permeable peptide (4HP4)-mediated adenoviral transduction. We confirmed the migratory capacity of UCB-MSC-IL12M toward GL26 mouse glioma cells by an in vitro migration assay and in vivo injection of UCB-MSC-IL12M into the ipsilateral hemisphere of implanted gliomas in C57BL/6 mice. In vivo efficacy experiments showed that intratumoral injection of UCB-MSC-IL12M significantly inhibited tumor growth and prolonged the survival of glioma-bearing mice compared with control mice. Antitumor effects were associated with increased local IL-12M levels, followed by interferon-γ secretion and T-cell infiltration in intracranial gliomas, as well as antiangiogenesis. Interestingly, tumor-free mice after UCB-MSC-IL12M treatment were resistant to ipsilateral and contralateral tumor rechallenge, which was closely associated with tumor-specific long-term T-cell immunity. Thus, our results provide the rationale for designing novel experimental protocols to induce long-term antitumor immunity against intracranial gliomas using UCB-MSCs as an effective delivery vehicle for therapeutic cytokines including IL-12M.</P>

Luminescence Property of ZnS:Mn,Mg Phosphor with Excitation of Plasma Blue Light Source

Ryu, Si Hong,Kim, Wan Kyu,Lee, Seong Eui The Korean Institute of Electrical and Electronic 2013 Transactions on Electrical and Electronic Material Vol.14 No.1

In this paper, we investigated the effect of luminescence properties of various concentrations of magnesium-doped ZnS:Mn phosphor excited by plasma luminescence device. The PL intensity was evaluated in the range of 300~500 nm excitation wavelengths. We found the highest PL intensity of the phosphors excited by 365 nm and 450 nm was observed at Mg concentrations of 1.4 wt% and 0.8 wt%, respectively. In addition, an emission peak was distinguished at 580 nm wavelength. With increasing Mg dopant level, enhanced PL intensity was observed, which is possibly applicable to color converting materials by blue emission for white light sources. Finally, we evaluated the luminance properties of color converting ZnS:Mn,Mg phosphors with plasma blue light source. the white luminance of plasma light source with CIE(0.36,0.26) was established by color converting phosphors of ZnS:Mn with 0.8 wt% Mg.

Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin

Ryu, Jinhyun,Yoon, Nal Ae,Seong, Hyemin,Jeong, Joo Yeon,Kang, Seokmin,Park, Nammi,Choi, Jungil,Lee, Dong Hoon,Roh, Gu Seob,Kim, Hyun Joon,Cho, Gyeong Jae,Choi, Wan Sung,Park, Jae-Yong,Park, Jeong Woo Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.11

Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of ARE-scontaining mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3' untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.