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Alterations of Epidermal Lipid Profiles and Skin Microbiome in Children With Atopic Dermatitis
Kim Jihyun,Kim Byung Eui,Goleva Elena,Berdyshev Evgeny,배재웅,Kim Seokjin,Kim Hye-young,Lee Un Ha,Kim Myoung Shin,Jung Minyoung,Kim Hyunmi,Lee Jinyoung,Donald Y.M. Leung,Ahn Kangmo 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2
Purpose: We aimed to investigate epidermal lipid profiles and their association with skin microbiome compositions in children with atopic dermatitis (AD). Methods: Specimens were obtained by skin tape stripping from 27 children with AD and 18 healthy subjects matched for age and sex. Proteins and lipids of stratum corneum samples from nonlesional and lesional skin of AD patients and normal subjects were quantified by liquid chromatography tandem mass spectrometry. Skin microbiome profiles were analyzed using bacterial 16S rRNA sequencing. Results: Ceramides with nonhydroxy fatty acids (FAs) and C18 sphingosine as their sphingoid base (C18-NS-CERs) N-acylated with C16, C18 and C22 FAs, sphingomyelin (SM) N-acylated with C18 FAs, and lysophosphatidylcholine (LPC) with C16 FAs were increased in AD lesional skin compared to those in AD nonlesional skin and that of control subjects (all P < 0.01). SMs N-acylated with C16 FAs were increased in AD lesional skin compared to control subjects (P < 0.05). The ratio of NS-CERs with long-chain fatty acids (LCFAs) to short-chain fatty acids (SCFAs) (C24-32:C14-22), the ratio of LPC with LCFAs to SCFAs (C24-30:C16-22) as well as the ratio of total esterified omega-hydroxy ceramides to total NS-CERs were negatively correlated with transepidermal water loss (rho coefficients = −0.738, −0.528, and −0.489, respectively; all P < 0.001). The proportions of Firmicutes and Staphylococcus were positively correlated to SCFAs including NS ceramides (C14-22), SMs (C17-18), and LPCs (C16), while the proportions of Actinobacteria, Proteobacteria, Bacteroidetes, Corynebacterium, Enhydrobacteria, and Micrococcus were negatively correlated to these SCFAs. Conclusions: Our results suggest that pediatric AD skin shows aberrant lipid profiles, and these alterations are associated with skin microbial dysbiosis and cutaneous barrier dysfunction.
유한요소법을 이용한 type 4 수소저장용기용 고정 장치의 구조적 안전성 분석에 관한 연구
김건우(GUNWOO KIM),김혜원(HYEWON KIM),박한민(HANMIN PARK),이정호(JEONGHO LEE),유수진(SUJIN YOON),이한수(HANSU LEE),김종열(JOUNGLYUL KIM),이석진(SEOKJIN LEE),유계형(GYEHYOUNG YOO),윤영길(YOUNGGIL YOUN),김한상(HANSANG KIM) 한국수소및신에너지학회 2024 한국수소 및 신에너지학회논문집 Vol.35 No.2
The study involves a finite element analysis to evaluate the structural integrity of the neck mount block for a type 4 hydrogen storage vessel, with the aim of enhancing its strength and rigidity. The existing neck mount block consists of a fixed part and a sliding part, each comprising a body block for load support, a screw part for neck boss fixation, and bolts. To analyze the vulnerabilities of the neck mount block under bolt fastening and load conditions relative to vehicle travel directions, a structural analysis process was developed. Comparative analysis between the enhanced design and the existing model was performed, resulting in improved strength and rigidity. The objective is to provide guidance for the current product development and to offer fundamental data for the design and structural analysis of future development projects.
Kim Sejin,Park So Yun,Moon Jungeun,Kim Heung Sik,Kang Seokjin 대한소아내분비학회 2023 Annals of Pediatirc Endocrinology & Metabolism Vol.28 No.3
Thyroid hormone resistance (RTH) is characterized by a decreased sensitivity of target tissues to thyroid hormones due to a defect in the THRα- and THRβ-encoded thyroid hormone receptors (THRs). The clinical manifestations range from no symptoms to simple goiter and hypo- or hyperthyroidism, depending on the receptor subtype distribution in the tissues. Here, we report the case of a thyroid hormone-resistant 12-month-old boy carrying a novel THRβ variant who was initially diagnosed with congenital hypothyroidism. An extensive evaluation revealed increased free T4 level and inappropriately increased thyroid-stimulating hormone (TSH) level; a normal lipid profile, sex hormone-binding globulin, and free alpha subunit of TSH; exaggerated TSH response to THR; and no radiological evidence of pituitary adenoma. A targeted next-generation sequencing panel identified a heterozygote c.993T>G (p.Asn331Lys) mutation in the THRβ gene. During the first year of life, a higher dose of levothyroxine was administered to the patient due to uncompensated RTH. Levothyroxine treatment was continued after 3 years to maintain TSH level <5 mIU/mL, but the observed weight gain was poor, height increase was insufficient, and bone development was delayed. However, neither hyperactivity nor developmental delay was observed. Patients with RTH exhibit various clinical features. Due to its heterogeneous nature, genetic test for accurate diagnosis is important to provide proper management.
Kim, Sung-Hoon,Yun, Seokjin,Choi, Jihoon,Kim, Jong H. Elsevier Sequoia 2018 Journal of photochemistry and photobiology Chemist Vol. No.
<P><B>Abstract</B></P> <P>In this work, we report on the photo-induced fluorescence switching film by using CH<SUB>3</SUB>NH<SUB>3</SUB>PbBr<SUB>3</SUB> perovskite nanoparticle fluorophore and spironaphthoxazine photochromic dye for the first time. Attributed to the effective spectral overlap between absorption of spironaphthoxazine in ring-opened merocyanine form and emission of CH<SUB>3</SUB>NH<SUB>3</SUB>PbBr<SUB>3</SUB> energy transfer-induced fluorescence switching film is demonstrated. In addition, both highly luminescent optical property of CH<SUB>3</SUB>NH<SUB>3</SUB>PbBr<SUB>3</SUB> and efficient photochromic reactivity of spironaphthoxazine, enabled high emission on/off emission contrast (>10.0) and fast emission turn on (4.0s). Finally, modulation of the switching speed is successfully achieved by introducing the chelating agent into the photochrmic film, which effectively retards the rate of photochromic reaction of spironaphthoxazine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fluorescence photo-switch is developed using perovskite nanoparticle fluorophore and photochromic photochromic dye. </LI> <LI> On/off contrast over >10.0 is achieved by taking advantage of highly luminescent property of perovskite nanoparticles. </LI> <LI> Turn on speed is effectively modulated by introducing the chelating additive that can retard photochromic reaction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>High on/off contrast photo-switchable fluorescence is demonstrated by combining highly luminescent fluorophore, CH<SUB>3</SUB>NH<SUB>3</SUB>PbBr<SUB>3</SUB> perovskite nanoparticles and photochromic dye, spironaphthoxazine.</P> <P>[DISPLAY OMISSION]</P>
Kim, Junggon,Lee, Hodan,Ji, Hankyul,Kim, Seokjin,Oh, Deuk-Sil,Jung, Sunghoon Elsevier 2017 Journal of Asia-Pacific biodiversity(Online) Vol.10 No.4
<P><B>Abstract</B></P> <P> <I>Paradasynus spinosus</I> Hsiao, 1963 (Hemiptera:Coreidae:Dasynini), with its higher taxon, the tribe Dasynini, and the genus <I>Paradasynus</I>, is reported from the Korean Peninsula for the first time. The morphological information such as diagnosis and description of male/female genitalia and biological note are presented with photographs and illustrations, and the possibility of its spread in Korea as an insect pest is discussed under climate change.</P>