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Lee, So-Ryoung,Choi, Eue-Keun,Rhee, Tae-Min,Lee, Hyun-Jung,Lim, Woo-Hyun,Kang, Si-Hyuck,Han, Kyung-Do,Cha, Myung-Jin,Cho, Youngjin,Oh, Il-Young,Oh, Seil Elsevier 2016 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.223 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atrial fibrillation (AF) is prevalent among type 2 diabetic patients. However, the association between diabetic retinopathy (DR) and AF is controversial.</P> <P><B>Methods</B></P> <P>We included 40,500 patients with type 2 diabetes (≥40years, mean age 62±11years, 53% men) without AF from the Korean National Insurance Service-National Sample Cohort (2002–2007). Subjects were classified without DR (non-DR, n=30,178), with DR (DR, n=8920), and with proliferative DR (PDR, n=1402).</P> <P><B>Results</B></P> <P>During a mean 5.9-year follow-up, 1261 (3.1%) patients were newly diagnosed as having AF (4.9, 6.0, and 8.3 per 1000 person-years in the non-DR, DR, and PDR groups, respectively). In multivariate Cox proportional hazard models, patients in the DR and PDR groups had a significantly higher risk of AF than those in the non-DR group (DR group: hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.00–1.30; PDR group: HR 1.46, 95% CI 1.13–1.87); p for trend <0.001). The risk of AF increased in patients with DR and end-stage renal disease (ESRD) (HR 2.39, 95% CI 1.31–3.96, p<0.001) and in those with PDR and ESRD (HR 3.59, 95% CI 1.96–5.97, p<0.001) compared to those without DR and ESRD.</P> <P><B>Conclusions</B></P> <P>The presence and severity of DR was significantly associated with the incidence of AF. Also, the presence of ESRD had an impact on the incidence of AF in patients with DR.</P>
<i>Oscillibacter</i> <i>ruminantium</i> sp. nov., isolated from the rumen of Korean native cattle
Lee, Geun-Hye,Rhee, Moon-Soo,Chang, Dong-Ho,Lee, Jonghwan,Kim, Seil,Yoon, Min Ho,Kim, Byoung-Chan International Union of Microbiological Societies 2013 International journal of systematic and evolutiona Vol.63 No.6
<P>A strictly anaerobic, Gram-negative, non-spore-forming bacterium, designated GH1<SUP>T</SUP>, was isolated from the rumen of Korean native cattle (HanWoo). Cells were straight to slightly curved rods (2.0–4.5 µm long) and were motile by peritrichous flagella. The isolate grew at 30–45 °C (optimum 40 °C), at pH 5.5–6.5 (optimum pH 6.0) and with up to 3.5 % (w/v) NaCl. Strain GH1<SUP>T</SUP> produced acid from <SMALL>d</SMALL>-glucose, <SMALL>d</SMALL>-ribose and <SMALL>d</SMALL>-xylose, with butyric acid being the major end product. The genomic DNA G+C content was 54.6 mol%. Based on comparative 16S rRNA gene sequence analysis, strain GH1<SUP>T</SUP> was most closely related to <I>Oscillibacter valericigenes</I> Sjm18-20<SUP>T</SUP> (97.3 % 16S rRNA gene sequence similarity). DNA–DNA hybridization between strain GH1<SUP>T</SUP> and <I>O. valericigenes</I> DSM 18026<SUP>T</SUP> showed 24 % reassociation. The major fatty acids were iso-C<SUB>13 : 0</SUB> (13.0 %), iso-C<SUB>15 : 0</SUB> (17.6 %), anteiso-C<SUB>15 : 0</SUB> (8.4 %) and C<SUB>14 : 0</SUB> (4.1 %), and the cellular fatty acid methyl esters as dimethylacetals (DMAs) were C<SUB>16 : 0</SUB> DMA (17.8 %), iso-C<SUB>15 : 0</SUB> DMA (15.2 %) and C<SUB>14 : 0</SUB> DMA (4.52 %). The cell-wall peptidoglycan of strain GH1<SUP>T</SUP> contained <I>meso</I>-diaminopimelic acid and the major cell-wall sugar was galactose. Based on 16S rRNA gene sequence similarity, phylogenetic analysis, DNA G+C content, DNA–DNA relatedness and distinct phenotypic characteristics, strain GH1<SUP>T</SUP> is classified in the genus <I>Oscillibacter</I> as a member of a novel species, for which the name <I>Oscillibacter</I> <I>ruminantium</I> sp. nov. is proposed. The type strain is GH1<SUP>T</SUP> ( = KCTC 15176<SUP>T</SUP> = NBRC 108824<SUP>T</SUP> = JCM 18333<SUP>T</SUP>).</P>
Atrial fibrillation risk in metabolically healthy obesity: A nationwide population-based study
Lee, HyunJung,Choi, Eue-Keun,Lee, Seung-Hwan,Han, Kyung-Do,Rhee, Tae-Min,Park, Chan-Soon,Lee, So-Ryoung,Choe, Won-Seok,Lim, Woo-Hyun,Kang, Si-Hyuck,Cha, Myung-Jin,Oh, Seil Elsevier/North-Holland Biomedical Press 2017 International journal of cardiology Vol.240 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Metabolically healthy obese (MHO) individuals are reported to have a marginal increase in cardiovascular risk; however, their atrial fibrillation (AF) risk is unclear. We aimed to assess AF risk in MHO individuals and identify whether AF development is associated with obesity or influenced by metabolic comorbidities.</P> <P><B>Methods</B></P> <P>A retrospective cohort of 389,321 individuals (age, 45.6±14.5years; male, 52.1%) was extracted from the Korean National Health Insurance sample database between 2004 and 2006 and followed-up for new-onset AF until 2013. Subjects with diabetes mellitus, hypertension, and/or dyslipidemia were classified as “metabolically unhealthy.” The cohort was stratified into four groups according to obesity and metabolic healthiness: metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), MHO, and metabolically unhealthy obese (MUO).</P> <P><B>Results</B></P> <P>AF was newly diagnosed in 5106 (1.3%) individuals during a mean follow-up of 7.5±1.5years. The AF incidence rates for the MHNO, MUNO, MHO, and MUO groups were 0.76, 2.66, 1.10, and 2.88 per 1000 person-years, respectively. Compared with the MHNO group, the MHO group had increased AF risk (adjusted hazard ratio, 1.30; 95% CI, 1.14–1.48) on multivariate analysis. One fourth of the MHO cohort became metabolically unhealthy, contributing to increased AF risk. Obesity was an independent risk factor for AF, and increased AF risk by 20%. Metabolic unhealthiness increased AF risk by around 40%, and of its components, hypertension contributed the most.</P> <P><B>Conclusions</B></P> <P>MHO individuals are at increased risk for AF development, and obesity was independently associated with elevated AF risk.</P>
Single‑Walled Carbon Nanotube‑Based Chemi‑Capacitive Sensor for Hexane and Ammonia
Seil Kim,Kyu-Hwan Lee,Ju-Yul Lee,Kyoung-Kook Kim,Yong-Ho Choa,Jae-Hong Lim 대한금속·재료학회 2019 ELECTRONIC MATERIALS LETTERS Vol.15 No.6
Two configurations of single-walled carbon nanotube-based chemi-capacitive gas sensors were fabricated, i.e., horizontaland vertical. Further, their sensing properties for hexane and ammonia (NH3) vapor were characterized and compared withchemi-resistive-type sensing properties. Upon exposure to hexane and NH3vapor, both capacitance and resistance variedas the analyte concentration increased. The sensing sensitivity measured along the horizontal direction increased with thedevice resistance. However, the capacitive sensing response along the vertical direction was independent of the number andfraction of semi-conductive single-walled carbon nanotubes. Furthermore, the vertical chemi-capacitive sensing responsewas dependent on the dipole moment of analytes.
Creation of myocardial fibrosis by transplantation of fibroblasts primed with survival factors
Lee, Dong-Won,Lee, Tae-Kyu,Cho, Ik-Sung,Park, Hyo Eun,Jin, Sooryeonhwa,Cho, Hyun-Jai,Kim, Soon Ha,Oh, Seil,Kim, Hyo-Soo American Physiological Society 2011 American journal of physiology, Heart and circulat Vol.301 No.3
<P> One of the major obstacles in the creation of myocardial fibrosis using fibroblasts is massive cell death after cell injection. To overcome this problem, a method that delivers fibroblasts primed with survival factors was studied. Cardiac fibroblasts were isolated from wild-type male C57BL/6 mice. Female mice were randomly placed into the following three groups: 1) fibroblasts transfected with β-galactosidase-containing adenovirus (control group), 2) fibroblasts treated with a necrosis inhibitor (NI group), and 3) fibroblasts transfected with Akt-containing adenovirus (Akt group). Pretreated cells were transplanted into the recipient heart by direct injection after a thoracotomy. Quantitative real-time PCR and morphometric analysis were performed to investigate the effects of survival factor priming on the induction of cell engraftment and fibrosis. In addition, a canine model was used to investigate the development of fibrosis and conduction modification using autologous dermal fibroblasts. The NI and Akt groups showed a better engraftment rate: 13 (NI group) and 7 (Akt group) times greater at 21 days compared with the control group. Increased fibrosis and conduction delay were also observed in the NI and Akt groups compared with the control group. Survival factor priming increased cellular engraftment and enhanced the efficacy of cell transplantation. Delivery of fibroblasts primed with survival factors might be a promising approach to develop conduction modification as a novel strategy to treat arrhythmias. </P>
이세일 ( Seil Lee ),윤성로츠 ( Sungroh Yoon ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2
차세데 성장동력으로서 세계적으로 스마트홈 시스템을 주목하고 있다. 이에 따라 ICT를 선도하는 기 업들에서는 앞다퉈 그 플랫폼을 선보이며 시장을 선점하려는 추세이다. 대표적으로 애플과 구글 그리 고 삼성에서는 각각 HomeKit, Nest 그리고 타이젠이라고 하는 플랫폼을 선보이고 경쟁이 가속화되고 있는 추세이다. 이들 플랫폼은 공통적으로 사물인터넷 개념을 기반으로 하고 있기에 개인정보 유출과 같은 위험을 극복해야할 과제로 갖고 있다. 또한 스마트홈 시스템은 가전들의 전력을 측정/모니터링하는 스마트미터 시스템을 흡수함으로써 AMI 구축과 스마트그리드 실현을 앞당길 것이다.
SSD 컨트롤러의 하드웨어 레벨 검증 플랫폼 비교 분석
이세일(Seil Lee),이명현(Myunghyun Rhee),윤성로(Sungroh Yoon) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1B
HDD를 대체하는 저장 매체로서 SSD가 널리 자리 잡기 위해서는 더욱 빠른 속도와 용량대비 저렴한 가격이 필요하다. 이를 위해선 집적도가 높은 낸드플래시를 효율적으로 사용하는 FTL 개발 및 용량을 크게 만들 때 발생하는 여러 문제를 해결할 컨트롤러 시스템의 빠른 개발이 요구된다. 이를 위해서 신뢰성과 범용성을 갖춘 FTL 검증 플랫폼이 필요하다. 본 논문에서는 이미 발표된 검증 플랫폼을 비교 분석하며 이들의 장단점과 앞으로 더 필요한 부분을 탐색해 본다.
Fabrication and characterization of thermochemical hydrogen sensor with laminated structure
Kim, Seil,Song, Yoseb,Lim, Hyo-Ryoung,Kwon, Young-Tae,Hwang, Tae-Yeon,Song, Eunpil,Lee, Songjun,Lee, Young-In,Cho, Hong-Baek,Choa, Yong-Ho Elsevier 2017 International journal of hydrogen energy Vol.42 No.1
<P><B>Abstract</B></P> <P>In this study, we reported the simple and cost-effective fabrication of thermochemical hydrogen (TCH) sensors composed of chalcogenide thin films and Pt/Al<SUB>2</SUB>O<SUB>3</SUB> powders. Chalcogenide thin films of two types, composed of Bi<SUB>2</SUB>Te<SUB>3</SUB> (monomorphic-type) and Bi<SUB>2</SUB>Te<SUB>3</SUB> Sb<SUB>2</SUB>Te<SUB>3</SUB> (four-leg PN junction-type), were prepared by electrochemical deposition. The Pt/Al<SUB>2</SUB>O<SUB>3</SUB> powder, which acts as a heating catalyst, was synthesized by impregnation of an Al<SUB>2</SUB>O<SUB>3</SUB> powder with an aqueous solution of platinum (IV) chloride pentahydrate. Its heating process was optimized via a hydrogen-sensing evaluation to control the size of the Pt particles. The monomorphic-type TCH sensor showed an output signal of 14.2 μV in response to 10 vol% hydrogen gas, whereas an output signal of 39.6 μV was obtained from a four-leg PN junction–type TCH sensor. Even though the n–p junction-type had the same deposition area as that of the monomorphic-type, the output signal of the n–p junction TCH sensor was greater by a factor of 2.8. In addition, the monomorphic-type TCH sensor had an inferior response time (T<SUB>90</SUB>) of 31 s and a longer recovery time (D<SUB>10</SUB>) of 38 s; the four-leg PN junction-type TCH sensor had a lowest response time of 27 s and a fastest recovery time of 9 s (in 3% H<SUB>2</SUB>/air at room temperature).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thermochemical hydrogen sensor composed of chalcogenide thin film and Pt/Al<SUB>2</SUB>O<SUB>3</SUB> catalyst was fabricated. </LI> <LI> Voltage signal of the n–p junction type sensor was higher than monomorphic type sensor. </LI> <LI> Heat dissipation of n–p junction type sensor was superior to that of monomorphic type one. </LI> <LI> Response and recovery time of n–p junction type sensor were 27.4 and 9.6 s in 3% H<SUB>2</SUB>/air. </LI> </UL> </P>