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Park, Seho,Koo, Ja Seung,Kim, Gun Min,Sohn, Joohyuk,Kim, Seung Il,Cho, Young Up,Park, Byeong-Woo,Park, Vivian Youngjean,Yoon, Jung Hyun,Moon, Hee Jung,Kim, Min Jung,Kim, Eun-Kyung Korean Cancer Association 2018 Cancer Research and Treatment Vol.50 No.3
<P><B>Purpose</B></P><P>Sentinel lymph node biopsy (SLNB) can be performed when node-positive disease is converted to node-negative status after neoadjuvant chemotherapy (NCT). Tattooing nodes might improve accuracy but supportive data are limited. This study aimed to investigate the feasibility of charcoal tattooing metastatic axillary lymph node (ALN) at presentation followed by SLNB after NCT in breast cancers.</P><P><B>Materials and Methods</B></P><P>Twenty patientswith cytology-proven node metastases prospectively underwent charcoal tattooing at diagnosis. SLNB using dual tracers and axillary surgery after NCT were then performed. The detection rate of tattooed node and diagnostic performance of SLNB were analyzed.</P><P><B>Results</B></P><P>All patients underwent charcoal tattooingwithout significant morbidity. Sentinel and tattooed nodes could be detected during surgery after NCT. Nodal pathologic complete response was achieved in 10 patients. Overall sensitivity, false-negative rate (FNR), negative predictive value, and accuracy of hot/blue SLNB were 80.0%, 20.0%, 83.3%, and 90.0%, respectively. Retrieving more nodes and favorable nodal response were associated with improved performance. The best accuracy was observed when excised tattooed node was calculated together (FNR, 0.0%). Cold/non-blue tattooed nodes of five patients were removed during non-sentinel axillary surgery but clinicopathological parameters did not differ compared to patients with hot/blue tattooed node detected during SLNB, suggesting the importance of the tattooing procedure itself to improve performance.</P><P><B>Conclusion</B></P><P>Charcoal tattooing of cytology-confirmed metastatic ALN at presentation is technically feasible and does not limit SLNB after NCT. The tattooing procedure without additional preoperative localization is advantageous for improving the diagnostic performance of SLNB in this setting.</P>
Detection of Circulating Tumor Cells in Breast Cancer Patients Using Cytokeratin-19 Real-Time RT-PCR
Park, Hyung Seok,Han, Hyun Ju,Lee, Soohyeon,Kim, Gun Min,Park, Seho,Choi, Yeon A,Lee, Jeong Dong,Kim, Gi Moon,Sohn, Joohyuk,Kim, Seung Il Yonsei University College of Medicine 2017 Yonsei medical journal Vol.48 No.5
<P><B>Purpose</B></P><P>The roles of circulating tumor cells (CTCs) as predictive and prognostic factors, as well as key mediators in the metastatic cascade, have been investigated. This study aimed to validate a method to quantify CTCs in peripheral blood using a real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay for cytokeratin (CK)-19 and to evaluate the utility of this assay in detecting CTCs in breast cancer patients.</P><P><B>Materials and Methods</B></P><P>Real-time monitoring PCR of fluorescently labeled specific hybridization probes for CK-19 mRNA was established. Peripheral blood samples from 30 healthy donors, 69 patients with early breast cancer, 47 patients with locally advanced breast cancer, and 126 patients with metastatic breast cancer were prospectively obtained and analyzed for CTC detection.</P><P><B>Results</B></P><P>CK-19 mRNA was not detectable in healthy subjects using the real-time RT-PCR method. The detection rates of CK-19 mRNA in breast cancer patients were 47.8% for early breast cancer (33/69), 46.8% for locally advanced breast cancer (22/47), and 61.1% for metastatic breast cancer (77/129). The detection rate of CK-19-positive CTCs in metastatic disease was slightly higher than early or locally advanced breast cancer; however, the detection rate according to disease burden was not statistically different (<I>p</I>=0.097). The detection rate was higher in patients with pleural metastasis (<I>p</I>=0.045). CTC detection was associated with poor survival (<I>p</I>=0.014).</P><P><B>Conclusion</B></P><P>A highly specific and sensitive CK-19 mRNA-based method to detect CTCs in peripheral blood in breast cancer patients can be used in further prospective studies to evaluate the predictive and prognostic importance of CTCs.</P>
HER2-specific aptide conjugated magneto-nanoclusters for potential breast cancer imaging and therapy
Park, Jinho,Park, Seho,Kim, Sunghyun,Lee, In-Hyun,Saw, Phei Er,Lee, Kwangyeol,Kim, Yong-Chul,Kim, Young-Joon,Farokhzad, Omid C.,Jeong, Yong Yeon,Jon, Sangyong The Royal Society of Chemistry 2013 Journal of materials chemistry. B, Materials for b Vol.1 No.36
Park, Vivian Youngjean,Yoon, Dahye,Koo, Ja Seung,Kim, Eun-Kyung,Kim, Seung Il,Choi, Ji Soo,Park, Seho,Park, Hyung Seok,Kim, Suhkmann,Kim, Min Jung,Zhou., Wen Wolters Kluwer Health 2016 Medicine Vol.95 No.15
<P><B>Abstract</B></P><P>High-resolution magic angle spinning (HR-MAS) magnetic resonance (MR) spectroscopy data may serve as a biomarker for breast cancer, with only a small volume of tissue sample required for assessment. However, previous studies utilized only a single tissue sample from each patient. The aim of this study was to investigate whether intratumoral location and biospecimen type affected the metabolic characterization of breast cancer assessed by HR-MAS MR spectroscopy</P><P>This prospective study was approved by the institutional review board and informed consent was obtained. Preoperative core-needle biopsies (CNBs), central, and peripheral surgical tumor specimens were prospectively collected under ultrasound (US) guidance in 31 patients with invasive breast cancer. Specimens were assessed with HR-MAS MR spectroscopy. The reliability of metabolite concentrations was evaluated and multivariate analysis was performed according to intratumoral location and biospecimen type.</P><P>There was a moderate or higher agreement between the relative concentrations of 94.3% (33 of 35) of metabolites in the center and periphery, 80.0% (28 of 35) of metabolites in the CNB and central surgical specimens, and 82.9% (29 of 35) of metabolites between all 3 specimen types. However, there was no significant agreement between the concentrations of phosphocholine (PC) and phosphoethanolamine (PE) in the center and periphery. The concentrations of several metabolites (adipate, arginine, fumarate, glutamate, PC, and PE) had no significant agreement between the CNB and central surgical specimens.</P><P>In conclusion, most HR-MAS MR spectroscopic data do not differ based on intratumoral location or biospecimen type. However, some metabolites may be affected by specimen-related variables, and caution is recommended in decision-making based solely on metabolite concentrations, particularly PC and PE. Further validation through future studies is needed for the clinical implementation of these biomarkers based on data from a single tissue sample.</P>
Analysis of Interference between UWB and ITS
Seho Park,Eun Cheol Kim,Jin Young Kim 한국전자파학회JEES 2009 Journal of Electromagnetic Engineering and Science Vol.9 No.4
In this paper, we have analyzed the effect of interference between ultra-wideband(UWB) and intelligent transport systems(ITS). The maximum possible UWB emission power and minimum possible distance between UWB devices and ITS are found. In order to analyze the interference, we employ the Monte-Carlo(MC) method. We consider six situations, which are indoor office line-of-sight(LOS), indoor office non-line-of-sight(NLOS), indoor residential LOS, indoor residential NLOS, outdoor rural LOS, and outdoor rural NLOS environments. From the simulation results, it is confirmed that coexistence between UWB and ITS devices can be realized in accordance with the emission mask of 19.3 ㏈ for indoor application or 19.3 ㏈ for an image system. And in the outdoors, coexistence between UWB and ITS devices can be realized if the emission mask is at least 1.6 ㏈ for vehicles' radar systems.
The effect of missing levels of nesting in multilevel analysis
Park, Seho,Chung, Yujin Korea Genome Organization 2022 Genomics & informatics Vol.20 No.3
Multilevel analysis is an appropriate and powerful tool for analyzing hierarchical structure data widely applied from public health to genomic data. In practice, however, we may lose the information on multiple nesting levels in the multilevel analysis since data may fail to capture all levels of hierarchy, or the top or intermediate levels of hierarchy are ignored in the analysis. In this study, we consider a multilevel linear mixed effect model (LMM) with single imputation that can involve all data hierarchy levels in the presence of missing top or intermediate-level clusters. We evaluate and compare the performance of a multilevel LMM with single imputation with other models ignoring the data hierarchy or missing intermediate-level clusters. To this end, we applied a multilevel LMM with single imputation and other models to hierarchically structured cohort data with some intermediate levels missing and to simulated data with various cluster sizes and missing rates of intermediate-level clusters. A thorough simulation study demonstrated that an LMM with single imputation estimates fixed coefficients and variance components of a multilevel model more accurately than other models ignoring data hierarchy or missing clusters in terms of mean squared error and coverage probability. In particular, when models ignoring data hierarchy or missing clusters were applied, the variance components of random effects were overestimated. We observed similar results from the analysis of hierarchically structured cohort data.
Park, Hyung Seok,Choi, Ji-Yeob,Lee, Mi-Jeong,Park, Seho,Yeo, Chang-Woo,Lee, Sang Seop,Shin, Jae-Gook,Park, Byeong-Woo The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.8
<P>The aim of the study was to evaluate the association between genetic polymorphisms of <I>CYP2D6</I> and outcomes in breast cancer patients with tamoxifen treatment. We evaluated the <I>CYP2D6</I> genetic polymorphisms in 766 breast cancer patients. Among them, 110 patients whose samples were prospectively collected before surgery and treated with tamoxifen were included to evaluate the association between <I>CYP2D6</I> and outcomes. The genotypes of <I>CYP2D6</I> were categorized as extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM) according to the activity score. The clinicopathologic features of 110 patients were not significantly different among the three groups except for the T-stage and nodal status. The high T-stage and axillary metastasis were more frequent in the PM group. While recurrence-free and overall survival in the PM group was poorer than the other groups, there was no significant difference between the EM and the IM group. The difference between the PM and the other groups on univariate analysis disappeared on multivariate analysis. These conflicting results suggest that the clinical value of <I>CYP2D6</I> polymorphisms is still unclear and more large-sized and comprehensively designed trials are necessary.</P>