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Pomegranate Juice Inhibits Sulfoconjugation in Caco-2 Human Colon Carcinoma Cells
Ayako Saruwatari,Shigeaki Okamura,Yoko Nakajima,Yuji Narukawa,Tadahiro Takeda,Hiroomi Tamura 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.4
Several fruit juices have been reported to cause food–drug interactions, mainly affecting cytochrome P450 activity; however, little is known about the effects of fruit juices on conjugation reactions. Among several fruit juices tested (apple, peach, orange, pineapple, grapefruit, and pomegranate), pomegranate juice potently inhibited the sulfoconjugation of 1-naphthol in Caco-2 cells. This inhibition was both dose- and culture time-dependent, with a 50% inhibitory concentration (IC50) value calculated at 2.7% (vol/vol). In contrast, no obvious inhibition of glucuronidation of 1-naphthol in Caco-2 cells was observed by any of the juices examined. Punicalagin, the most abundant antioxidant polyphenol in pomegranate juice, was also found to strongly inhibit sulfoconjugation in Caco-2 cells with an IC50 of 45 μM, which is consistent with that of pomegranate juice. These data suggest that punicalagin is mainly responsible for the inhibition of sulfoconjugation by pomegranate juice. We additionally demonstrated that pomegranate juice and punicalagin both inhibit phenol sulfotransferase activity in Caco-2 cells in vitro, at concentrations that are almost equivalent to those used in the Caco-2 cells. Pomegranate juice, however, shows no effects on the expression of the sulfotransferase SULT1A family of genes (SULT1A1 and SULT1A3) in Caco-2 cells. These results indicate that the inhibition of sulfotransferase activity by punicalagin in Caco-2 cells is responsible for the reductions seen in 1-naphthyl sulfate accumulation. Our data also suggest that constituents of pomegranate juice, most probably punicalagin, impair the enteric functions of sulfoconjugation and that this might have effects upon the bioavailability of drugs and other compounds present in food and in the environment. These effects might be related to the anticarcinogenic properties of pomegranate juice.
A new design method for site-joints of the tower crane mast by non-linear FEM analysis
Ushio, Yoshitaka,Saruwatari, Tomoharu,Nagano, Yasuyuki Techno-Press 2019 Advances in computational design Vol.4 No.4
Among the themes related to earthquake countermeasures at construction sites, those for tower cranes are particularly important. An accident involving the collapse of a crane during the construction of a skyscraper has serious consequences, such as human injury or death, enormous repair costs, and significant delays in construction. One of the causes of deadly tower crane collapses is the destruction of the site joints of the tower crane mast. This paper proposes a new design method by static elastoplastic finite element analysis using a supercomputer for the design of the end plate-type tensile bolted joints, which are generally applied to the site joints of a tower crane mast. This new design method not only enables highly accurate and reliable joint design but also allows for a design that considers construction conditions, such as the introduction of a pre-tension axial force on the bolts. By applying this new design method, the earthquake resistance of tower cranes will undoubtedly be improved.
Elastoplastic FEM analysis of earthquake response for the field-bolt joints of a tower-crane mast
Ushio, Yoshitaka,Saruwatari, Tomoharu,Nagano, Yasuyuki Techno-Press 2019 Advances in computational design Vol.4 No.1
Safety measures for tower cranes are extremely important among the seismic countermeasures at high-rise building construction sites. In particular, the collapse of a tower crane from a high position is a very serious catastrophe. An example of such an accident due to an earthquake is the case of the Taipei 101 Building (the author was the project director), which occurred on March 31, 2002. Failure of the bolted joints of the tower-crane mast was the direct cause of the collapse. Therefore, it is necessary to design for this eventuality and to take the necessary measures on construction sites. This can only be done by understanding the precise dynamic behavior of mast joints during an earthquake. Consequently, we created a new hybrid-element model (using beam, shell, and solid elements) that not only expressed the detailed behavior of the site joints of a tower-crane mast during an earthquake but also suppressed any increase in the total calculation time and revealed its behavior through computer simulations. Using the proposed structural model and simulation method, effective information for designing safe joints during earthquakes can be provided by considering workability (control of the bolt pretension axial force and other factors) and less construction cost. Notably, this analysis showed that the joint behavior of the initial pretension axial force of a bolt is considerably reduced after the axial force of the bolt exceeds the yield strength. A maximum decrease of 50% in the initial pretension axial force under the El Centro N-S Wave ($v_{max}=100cm/s$) was observed. Furthermore, this method can be applied to analyze the seismic responses of general temporary structures in construction sites.
Static and seismic response analyses of new seismic integrated ceiling using FEM
Lyu, Zhilun,Sakaguchi, Masakazu,Saruwatari, Tomoharu,Nagano, Yasuyuki Techno-Press 2021 Advances in computational design Vol.6 No.4
The seismic performances of suspended ceilings are mostly evaluated via shaking table tests, whose results can be intuitively understood. However, these tests become impracticable when the ceiling surface area is beyond the limit of the shake table. Hence, simulation analysis becomes an alternative method. However, simulation analysis for suspended ceilings has not been yet developed and is used as an auxiliary method. To provide a new approach for evaluating the seismic performances of suspended ceilings, we have proposed numerical models for a new seismic integrated ceiling in previous studies, including 1) models (shell elements) for the intersections of the ceiling members and 2) models (beam elements) for ceiling units. Based on our previous studies, we created a model with a ceiling surface area of 264 m<sup>2</sup> and analyzed via LS-DYNA as an example to evaluate the seismic performance of the new seismic integrated ceiling. To confirm the seismic behavior of the new seismic integrated ceiling during earthquakes, as an example, JMA Kobe earthquake waves were input into the simulation model for the first time. Via the simulation analysis, it was confirmed that the seismic performance of the new seismic integrated ceiling was satisfactory even when the ceiling surface area exceeded 200 m<sup>2</sup>.
Tests of integrated ceilings and the construction of simulation models
Lyu, Zhilun,Sakaguchi, Masakazu,Saruwatari, Tomoharu,Nagano, Yasuyuki Techno-Press 2019 Advances in computational design Vol.4 No.4
This paper proposes a new approach to model the screw joints of integrated ceilings via the finite element method (FEM). The simulation models consist of the beam elements. The screw joints used in the main bars and cross bars and in the W bars and cross bars are assumed to be rotation springs. The stiffness of the rotation springs is defined according to the technical standards proposed by the National Institute for Land and Infrastructure Management of Japan. By comparing the results of the sheer tests and the simulation models, the effectiveness and efficiency of the simulation models proposed in this paper are verified. This paper indicates the possibility that the seismic performance of suspended ceilings can be confirmed directly via beam element models using FEM if the stiffnesses of the screw joints of the ceiling substrates are appropriately defined. Because cross-sectional shapes, physical properties, and other variables of the ceiling substrates can be easily changed in the models, it is expected that suspended ceiling manufactures will be able to design and confirm the seismic performance of suspended ceilings with different cross-sectional shapes or materials via computers, instead of spending large amounts of time and money on shake table tests.