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Indomethacin 유발 소장염증 모델에서 Fibroblast Growth Factor-10 투여에 의한 염증 조절기전에 관한 연구
한동수,Sartor, R. Balfour 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6
Background/Aims: Fibroblast growth factor-10 (FGF-10) is a homolog of keratinocyte growth factor-2 with epithelial mitogenic activity. We investigated the therapeutic role of FGF-10 in intestinal ulceration and its mechanism of protection. Methods: FGF-10 was administered before or after induction of small intestinal ulceration by indomethacin. FGF-10 was injected subcutaneously (1 or 5 mg/kg) and intravenously (1 mg/kg) daily for 6 days (acute study). Injury was evaluated by double-blinded macroscopic and microscopic scores, and the concentration of tissue interleukin (IL)-1β and the expression of collagen type I RNA were compared. It was determined whether FGF-10 has an effect on in vitro epithelial cellular proliferation, restitution of wounded monolayers, the expression of cyclooxygenase-2 (COX-2) and collagen, and regulation of NF-κB. Results: Intravenous FGF-10 significantly decreased acute intestinal injury by all parameters. FGF-10 promoted in vitro proliferation and migration of epithelial cell, anstimulated COX-2 expression, but had no effect on IκB degradation. FGF-10 affected up-regulated collagen expression in cultured myofibroblasts but not in vivo fibrosis. Conclusions: FGF-10 treats intestinal inflammation by actively promoting the mechanism to heal epithelial cells.
Bejleri Valbona,Sartore Luca,Nandram Balgobin 한국통계학회 2022 Journal of the Korean Statistical Society Vol.51 No.3
Bayesian prediction limits are constructed based on some maximum allowed probability of wrong prediction. However, the frequency of wrong prediction in a long run often exceeds this probability. The literature on frequentist and Bayesian prediction limits, and their interpretation is sparse; more attention is given to prediction intervals obtained based on parameter estimates or empirical studies. Under the Poisson distribution, we investigate frequentist properties of Bayesian prediction limits derived from conjugate priors. The frequency of wrong prediction is used as a criterion for their comparison. Bayesian prediction based on the uniform and Jeffreys’ non-informative priors yield one sided prediction limits that can be interpreted in a frequentist context. It is shown here, by proving a theorem, that Bayesian lower prediction limit derived from Jeffreys’ noninformative prior is the only optimal (largest) Bayesian lower prediction limit that possesses frequentist properties. In addition, it is concluded as corollary that there is no prior distribution such that Bayesian upper and lower prediction limits obtained from it will both coincide with their respective frequentist prediction limits. Our results are based on asymptotic considerations. An example with real data is included, and the sensitivity of the Bayesian prediction limits with respect to conjugate priors is numerically explored through simulations.
Towards Ordered, Uniformly-Sized ZnO Single-Crystal Nanorod Arrays
Huijuan Zhou,Markus Wissinger,Johannes Fallert,Robert Hauschild,Felix Stelzl,Mario Hauser,Janos Sartor,Claus Klingshirn,Heinz Kalt 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
By using a catalyst-assisted vapor phase deposition method, we recently fabricated high-quality ordered ZnO nanorod arrays with uniform rod size. The rods, grown perpendicularly on GaN/Al2O3 substrates, were [0001]-oriented single crystals with diameters of 200 nm, length of 4.7 µm, and rod-to-rod spacings of 500 nm. The growth conditions, including the choice of the substrate, the patterning of the catalyst on the substrate, and the growth parameters, played important roles in determining the morphology of the rods, and the best samples were produced under optimized conditions. Time-resolved micro-photoluminescence measurements on single nanorods demonstrated laser emission at temperatures up to room temperature. These high-crystal-quality nanorod arrays may be promising candidates for ultraviolet nanolaser arrays.
Evaluation of an Active Humidification System for Inspired Gas
Nicolás G. Roux,Gustavo A. Plotnikow,Darío S. Villalba,Emiliano Gogniat,Vivivana Feld,Noelia Ribero Vairo,Marisa Sartore,Mauro Bosso,José L. Scapellato,Dante Intile,Fernando Planells,Diego Noval,Pablo 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.1
Objectives. The effectiveness of the active humidification systems (AHS) in patients already weaned from mechanical ventilation and with an artificial airway has not been very well described. The objective of this study was to evaluate the performance of an AHS in chronically tracheostomized and spontaneously breathing patients. Methods. Measurements were quantified at three levels of temperature (Tº) of the AHS: level I, low; level II, middle; and level III, high and at different flow levels (20 to 60 L/minute). Statistical analysis of repeated measurements was performed using analysis of variance and significance was set at a P<0.05. Results. While the lowest temperature setting (level I) did not condition gas to the minimum recommended values for any of the flows that were used, the medium temperature setting (level II) only conditioned gas with flows of 20 and 30 L/minute. Finally, at the highest temperature setting (level III), every flow reached the minimum absolute humidity (AH) recommended of 30 mg/L. Conclusion. According to our results, to obtain appropiate relative humidity, AH and T° of gas one should have a device that maintains water T° at least at 53°C for flows between 20 and 30 L/m, or at T° of 61°C at any flow rate.
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Han, Jaeseok,Back, Sung Hoon,Hur, Junguk,Lin, Yu-Hsuan,Gildersleeve, Robert,Shan, Jixiu,Yuan, Celvie L.,Krokowski, Dawid,Wang, Shiyu,Hatzoglou, Maria,Kilberg, Michael S.,Sartor, Maureen A.,Kaufman, Ra Nature Publishing Group, a division of Macmillan P 2013 Nature cell biology Vol.15 No.5
Protein misfolding in the endoplasmic reticulum (ER) leads to cell death through PERK-mediated phosphorylation of eIF2α, although the mechanism is not understood. ChIP-seq and mRNA-seq of activating transcription factor 4 (ATF4) and C/EBP homologous protein (CHOP), key transcription factors downstream of p-eIF2α, demonstrated that they interact to directly induce genes encoding protein synthesis and the unfolded protein response, but not apoptosis. Forced expression of ATF4 and CHOP increased protein synthesis and caused ATP depletion, oxidative stress and cell death. The increased protein synthesis and oxidative stress were necessary signals for cell death. We show that eIF2α-phosphorylation-attenuated protein synthesis, and not Atf4 mRNA translation, promotes cell survival. These results show that transcriptional induction through ATF4 and CHOP increases protein synthesis leading to oxidative stress and cell death. The findings suggest that limiting protein synthesis will be therapeutic for diseases caused by protein misfolding in the ER.