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- 저자 : Sarmila Amatya (검색결과 3 건)
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Drug release testing methods of polymeric particulate drug formulations
Sarmila Amatya,박은지,박종훈,김준식,설은영,이희영,최호일,신영희,나동희 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.4
The long-term controlled delivery of drugs has been successfully achieved by biodegradable polymeric particulate systems. The drug release testing method is important for the characterization of dosage form performance under in vitro standardized conditions and can provide insight into the in vivo performance of the drug product. In vitro drug release testing methods for polymeric particulate systems are classified into sample and separate (SS), dialysis, and continuous flow (CF) methods. In the SS method, the drug-loaded microparticles are suspended in a vessel and the samples for the analysis are obtained by separating the particles using filtration or centrifugation. The dialysis method physically separates microparticles from the release media by a membrane, which eliminates the undesired loss of particles during sample preparation and handling. The CF method uses apparatus consisted of flow-through cell that holds the sample, pump and water bath in closed or open ends system. In this method, the release media is continuously circulated through a cell containing drug-loaded microparticles. This review summarizes the principles of the drug release testing methods and discusses their characteristics with the recent research results.
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Long-acting injectable formulations of antipsychotic drugs for the treatment of schizophrenia
박은지,Sarmila Amatya,Myung Sun Kim,Jong Hoon Park,Eunyoung Seol,Heeyong Lee,신영희,나동희 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
Antipsychotic drugs have been used to treatpatients with schizophrenia and other psychotic disorders. Long-acting injectable antipsychotic drugs are useful forimproving medication compliance with a better therapeuticoption to treat patients who lack insight or adhere poorly tooral medication. Several long-acting injectable antipsychoticdrugs are clinically available. Haloperidol decanoateand fluphenazine decanoate are first-generation depotdrugs, but the use of these medicines has declined since theadvent of second-generation depot agents, such as longactingrisperidone, paliperidone palmitate, and olanzapinepamoate. The second-generation depot drugs are bettertolerated and have fewer adverse neurological side effects. Long-acting injectable risperidone, the first depot formulationof an atypical antipsychotic drug, was prepared byencapsulating risperidone into biodegradable microspheres. Paliperidone palmitate is an aqueous suspension of nanocrystalmolecules, and olanzapine pamoate is a microcrystallinesalt of olanzapine and pamoic acid suspended inaqueous solution. This review summarizes the characteristicsand recent research of formulations of each longactinginjectable antipsychotic drug.
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Jae Sung Pyo(표재성),Sarmila Shrestha (Amatya)(사밀라 스레스타(아마티아)),Song Hee Park(박송희),Jae Seon Kang(강재선) 한국생명과학회 2014 생명과학회지 Vol.24 No.12
식물성장촉진 뿌리박테리아(PGPR)을 사용한 생물학적 조절(Biological control)은 최근 몇년 동안에 주목 받게되었다. PGPR은 산업적으로 중요한 감자, 토마토 그리고 쌀과 같은 경제적으로 중요한 작물의 성장촉진과 관련되어있다. 음식물 쓰레기에서 발견된 Bacillus mojavensis KJS-3은 Aspergillus terreus, A. fumagatus, A. flavus and Fusarium redolense에 대해 항진균작용을 가지고 있는 균주로, 이미 여러 산업적인 측면에서 유용한 가능성이 확인된 균주이다. 본 연구에서는 Bacillus mojavensis KJS-3를 알타리무와 상추에 0.5×10<SUP>9</SUP> cfu/g, 1.0×10<SUP>9</SUP> cfu/g 및 2.0×10<SUP>9</SUP> cfu/g의 3가지 농도로 분무, 재배한 후, 잎의 수, 길이, 무게, 뿌리와 근경의 길이, 넓이 및 무게를 비교함으로써, 이들에 대한 생육촉진작용을 확인해보았다. 그 결과, 처리하지 않은 군에 비하여 Bacillus mojavensis KJS-3를 처리한 군이 더 높은 생육성장을 보였으며, 1.0×10<SUP>9</SUP> cfu/g농도에서의 재배는 저농도에서의 재배보다 더 높은 생육성장을 그리고 고농도에서의 재배와 비슷한 생육성장을 나타내었다. 이러한 결과를 토대로 B. mojavensis KJS-3의 생물학적 비료로서의 가능성을 확인할 수 있었으며, 또한 B. mojavensis KJS-3의 다른 작물에 대한 생육조절제의 적용도 가능할 것으로 예상된다. Biological control using the plant growth-promoting Rhizobacterium (PGPR) has received significant attention in recent years. PGPR has been linked with promoting growth in economically important crops, such as potatoes, tomatoes, and rice. Bacillus mojavensis KJS-3 (Moja-3), isolated from food waste, possesses antifungal properties against Aspergillus terreus, A. fumagatus, A. flavus, and Fusarium redolense, and it may have potential in the development of products for industrial applications. The main purpose of this study was to determine the effects of spraying the PGPR Bacillus mojavensis KJS-3 on the growth of altari radish (leaf number, leaf length, leaf weight, root length, and rhizome length, adjacent portion diameter, and weight) and lettuce (leaf number, length, width, and weight). Three different concentrations of the foliar spray treatment of B. mojavensis KJS-3 were applied to the altari radish and lettuce: the recommended standard concentration of 1×10<SUP>9</SUP> cfu/g, half the standard concentration of 0.5×10<SUP>9</SUP> cfu/g, and double the standard concentration of 2×10<SUP>9</SUP> cfu/g). The B. mojavensis strain foliar spray treatment increased the growth of the leaves and roots of the altari radish and increased the growth of the lettuce leaves. For both plants, the recommended concentration of B. mojavensis KJS-3 produced better growth than half the standard concentration, and the growth was similar with the double dose. This study demonstrates positive effects of Moja-3, suggesting it may be a potential new bio-fertilizer for improving the growth of altari radish and lettuce.
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