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Oh, Sangmi,Cho, Sun Wook,Yang, Jae-Yeon,Sun, Hyun Jin,Chung, Young Sun,Shin, Chan Soo,Park, Seung Bum Royal Society of Chemistry 2011 MedChemComm Vol.2 No.1
<P>A novel osteogenic agent containing a benzopyranyl core skeleton was discovered from cell-based alkaline phosphatase (ALP) assay of a small-molecule library constructed by diversity-oriented synthetic approach. The subsequent structure–activity relationship study using ALP and TOPflash reporter gene assay confirmed 6b as an osteogenesis activator. In <I>in vivo</I> study, we successfully demonstrated that the oral treatment of ovariectomized mice with 6b resulted in increased bone mass and bone volume as well as improved bone quality.</P> <P>Graphic Abstract</P><P>A novel osteogenic agent was discovered from cell-based alkaline phosphatase (ALP) assay of a small-molecule library constructed by diversity-oriented synthetic approach. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00149j'> </P>
( Sangmi Jang ),( Gwang Hyeon Choi ),( Sung-ho Hwang ),( Jaewon Park ),( Won Joon Choi ),( Woo Jin Jung ),( Eun Sun Jang ),( Jin-wook Kim ),( Sook-hyang Jeong ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Alpha-fetoprotein (AFP) is a well-known biomarker of liver cancer and liver injury. However, apparently healthy individuals having AFP elevation on heath check-ups were encountered in clinics. Their clinical features and cause of AFP elevation were not clear. Thus, we aim to investigate the clinical characteristics of the patients with an “elevated AFP level” (>7 ng/ mL cutoff), and its relation with body fat deposition in terms of hepatic steatosis and visceral adiposity. Methods: Patients having a diagnostic code of “elevated AFP level” (R772) were searched from 2009 to 2018 in a tertiary hospital. After excluding patients with any malignancies, liver cirrhosis, or viral hepatitis, 146 patients were included in the case group. As a control group, age and sex-matched 146 hepatic hemangioma (<3cm) patients were selected. Among the subgroup of case (n=49) and controls (n=49) who underwent liver CT, hepatic fat and visceral fat were measured using the pre-contrast CT image. Results: The case group showed a mean age of 48.7 years, male proportion of 64.4%, and a higher mean serum AFP level (12.76 ng/mL) than the control (2.85 ng/mL). The case group showed a higher prevalence of dyslipidemia (21.2 vs 3.4%, P<0.001) and hypertension (11.6 vs 4.8%, P=0.033), but a lower body mass index (BMI) (22.68 vs 23.85 kg/m2, P=0.003) than the control. Total-bilirubin level was higher in the case group (0.8 vs 0.5 mg/dL, P<0.001), but other laboratory results were similar to the control group. Hepatic fat measured by Hounsfield units of 8 regions of liver segments and visceral adiposity index in the subgroups of case and control were not different (59.40 vs 61.76, P=0.158 and 28.53 vs 27.32 ㎠/㎡, P=0.788, respectively). Conclusions: Asymptomatic patients with an elevated AFP level showed a higher prevalence of hypertension and dyslipidemia despite lower BMI than controls. Its relationship with abnormal fat metabolism warrants further study.
사회적경제 인식은 공동체의식과 임파워먼트에 영향을 미치는가? : 서울시민의 인식을 중심으로
조상미(Sangmi Cho),박윤세(Yoonsei Park),정지수(Jeesoo Jung),정선희(Sun Hee Chung),정승애(Seung Ae Jung) 충북대학교 국제개발연구소 2021 사회적경제와 정책연구 Vol.11 No.2
사회적경제는 시민이 주체가 되어 자발적으로 공동체 속에서 사회문제를 해결하는 방식으로, 오랜 역사 속에서 존재해온 가치이다. 국내 사회적경제는 2000년대 이후 법적·제도적 기반 마련을 토대로 급속한 양적 성장을 이루었으나, 대중의 인식은 여전히 낮게 나타나고 있다. 이에 본 연구에서는 지금까지 사회적경제 분야 연구에서 상대적으로 주목받지 못했던 시민의 인식에 관한 연구를 수행하였다. 연구내용은 첫째, 통합적으로 사회적경제 인식을 측정하기 위해 문항을 개발하고, 둘째, 서울 시민을 대상으로 하여 사회적경제 인식이 공동체의식과 임파워먼트에 어떠한 영향을 미치는지 살펴보았다. 연구결과, 사회적경제 인식을 ‘전반적 인지’, ‘조직 인지’, ‘현재 인식’, ‘미래 기대’ 네 가지 하위요인으로 분류할 수 있었다. 또한, 사회적경제에 대한 인식이 높을수록 공동체의식이 상승하고 임파워먼트가 확대되는 긍정적인 영향력을 보였다. 본 연구는 사회적경제 인식 측정도구 개발에 관한 최초의 연구이자, 대규모의 실증 데이터를 활용하여 사회적경제 인식의 영향을 살펴본 연구라는 점에서 의의가 있으며, 추후 사회적경제 인식에 관한 기초 연구자료로 활용이 가능할 것이다. This study intends to develop an instrument for measuring the perception of Social Economy and explore how it affects the sense of community and empowerment. The sample included 1,302 Seoul citizen through Proportionate Stratified Sampling. Factor Analysis and Hierarchical Regression Analysis were conducted. 4 sub-factors (General Awareness, Organization Awareness, Current Perception, and Future Expectations) were extracted and Current Perception was the most critical factor. Both the sense of community and empowerment became stronger as the perception got higher. This study is the first research to develop the measurement of the perception of Social Economy and it is unique and meaningful as it investigates the effects of the Social Economy perception on the sense of community and empowerment.
재배활동중심 원예치료 프로그램이 여자 성인 수형자의 정신건강에 미치는 영향
이상미(Sangmi Lee),문지혜(Ji Hye Moon),정순진(Sun Jin Jeong),김경미(Gyung Mee Gim),제의숙(Eu Sook Jea) 인간식물환경학회 2014 인간식물환경학회지 Vol.17 No.4
The purpose of this study was to investigate the effect of horticultural therapy program focused on cultivation activities for female adult prisoners on mental health. 20 female adult prisoners were participated. Experimental group of 10 members received a horticultural therapy program and control group of 10 members did not receive a horticultural therapy program. And this study was performed from 26th of April 2013 to 12th of July 2013. ‘Horticultural therapy program focused on cultivation activities(Lee et al., 2013)’ which was based on ‘conceptual frame of psychological outcome model in horticultural therapy for prisoners scheduled for release(Rural Development Administration, 2012)’ was applied. As the results, interpersonal sensitivity level of the experimental group decreased significantly after horticultural therapy(p=0.028), while in control group was not showed significant on 9 domains of symptom. Therefore horticultural therapy program focused on cultivation activities could be utilized as appropriate rehabilitation program for increase of mental health in female adult prisoners in future.