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A Quantitative Method of Measuring Color Expression Power in Eye shadow
( Sangjune Kim ),( Jaeuk Lee ),( Hyungjin Kim ),( Jinjun Kim ),( Seh-hun Kang ) 대한화장품학회 2000 대한화장품학회지 Vol.26 No.1
We developed a quantitative method for evaluating CEP(color expression power) in eye shadow. This method enables the cosmetic industry to measure CEP on an interval scales, so it is more accurate and reproducible than previous panel tests. Oil, colorants, Pigments and pearls are major factors affecting CEP in eye shadow formulas. We studied the oil effect on CEP using our unique method so CEP could be improved. We believe this method can be applied to other color cosmetics as well. In conclusion, we expected this method to be useful to formulator who want to improve the color expression power in color cosmetics. Additionally, we hope it will contribute toward developing the experiential know-how about color to scientific knowledge.
Kim, Sangjune,Park, Do-Young,Lee, Dohyun,Kim, Wanil,Jeong, Young-Hun,Lee, Juhyun,Chung, Sung-Kee,Ha, Hyunjung,Choi, Bo-Hwa,Kim, Kyong-Tai American Society for Microbiology 2014 Molecular and cellular biology Vol.34 No.4
<P>Misfolding of proteins containing abnormal expansions of polyglutamine (polyQ) repeats is associated with cytotoxicity in several neurodegenerative disorders, including Huntington's disease. Recently, the eukaryotic chaperonin TRiC hetero-oligomeric complex has been shown to play an important role in protecting cells against the accumulation of misfolded polyQ protein aggregates. It is essential to elucidate how TRiC function is regulated to better understand the pathological mechanism of polyQ aggregation. Here, we propose that vaccinia-related kinase 2 (VRK2) is a critical enzyme that negatively regulates TRiC. In mammalian cells, overexpression of wild-type VRK2 decreased endogenous TRiC protein levels by promoting TRiC ubiquitination, but a VRK2 kinase-dead mutant did not. Interestingly, VRK2-mediated downregulation of TRiC increased aggregate formation of a polyQ-expanded huntingtin fragment. This effect was ameliorated by rescue of TRiC protein levels. Notably, small interference RNA-mediated knockdown of VRK2 enhanced TRiC protein stability and decreased polyQ aggregation. The VRK2-mediated reduction of TRiC protein levels was subsequent to the recruitment of COP1 E3 ligase. Among the members of the COP1 E3 ligase complex, VRK2 interacted with RBX1 and increased E3 ligase activity on TRiC <I>in vitro</I>. Taken together, these results demonstrate that VRK2 is crucial to regulate the ubiquitination-proteosomal degradation of TRiC, which controls folding of polyglutamine proteins involved in Huntington's disease.</P>
Kim, Sangjune,Lee, Dohyun,Lee, Juhyun,Song, Haengjin,Kim, Hyo-Jin,Kim, Kyong-Tai American Society for Microbiology 2015 Molecular and cellular biology Vol.35 No.10
<P>Molecular chaperones monitor the proper folding of misfolded proteins and function as the first line of defense against mutant protein aggregation in neurodegenerative diseases. The eukaryotic chaperonin TRiC is a potent suppressor of mutant protein aggregation and toxicity in early stages of disease progression. Elucidation of TRiC functional regulation will enable us to better understand the pathological mechanisms of neurodegeneration. We have previously shown that vaccinia-related kinase 2 (VRK2) downregulates TRiC protein levels through the ubiquitin-proteasome system by recruiting the E3 ligase COP1. However, although VRK2 activity was necessary in TRiC downregulation, the phosphorylated substrate was not determined. Here, we report that USP25 is a novel TRiC interacting protein that is also phosphorylated by VRK2. USP25 catalyzed deubiquitination of the TRiC protein and stabilized the chaperonin, thereby reducing accumulation of misfolded polyglutamine protein aggregates. Notably, USP25 deubiquitinating activity was suppressed when VRK2 phosphorylated the Thr<SUP>680</SUP>, Thr<SUP>727</SUP>, and Ser<SUP>745</SUP> residues. Impaired USP25 deubiquitinating activity after VRK2-mediated phosphorylation may be a critical pathway in TRiC protein destabilization.</P>
Kim, Seong-Hoon,Lyu, Ha-Na,Kim, Ye Seul,Jeon, Yong Hyun,Kim, Wanil,Kim, Sangjune,Lim, Jong-Kwan,Lee, Ho Won,Baek, Nam-In,Choi, Kwan-Yong,Lee, Jaetae,Kim, Kyong-Tai American Society for Pharmacology and Experimental 2015 The Journal of Pharmacology and Experimental Thera Vol.352 No.1
<P>To date, many anticancer drugs have been developed by directly or indirectly targeting microtubules, which are involved in cell division. Although this approach has yielded many anticancer drugs, these drugs produce undesirable side effects. An alternative strategy is needed, and targeting mitotic exit may be one alternative approach. Localization of phosphorylated barrier-to-autointegration factor (BAF) to the chromosomal core region is essential for nuclear envelope compartment relocalization. In this study, we isolated brazilin from Caesalpinia sappan Leguminosae and demonstrated that it inhibited BAF phosphorylation in vitro and in vivo. Moreover, we demonstrated direct binding between brazilin and BAF. The inhibition of BAF phosphorylation induced abnormal nuclear envelope reassembly and cell death, indicating that perturbation of nuclear envelope reassembly could be a novel approach to anticancer therapy. We propose that brazilin isolated from C. sappan may be a new anticancer drug candidate that induces cell death by inhibiting vaccinia-related kinase 1-mediated BAF phosphorylation.</P>
전통의학 정보포털 활성화를 위한 한의전문가 의견분석에 관한 연구
예상준(Sangjun Yea),장현철(Hyunchul Jang),김상균(Sangkyun Kim),김진현(Jinhyun Kim),김철(Chul Kim),김익태(Iktae Kim),장윤지(Yunji Jang),김창석(Changseok Kim),송미영(Miyoung Song) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.1
We surveyed attendee at TKM Information Common Application Committee who are the chairman of TKM journals, the dean of oriental medicine colleges and the head of oriental medicine institutes. We analyzed the survey results to activate OASIS and to more utilize OASIS in TKM research. From the analysis, the experts predict that TKM literature information and combined search connected to internal/external TM database are most applicable to OASIS. If the contents and functions are provided in OASIS, experts said that they will use more 2.2 times than now. We drew the future plan of OASIS from the 2 survey analysis which are conducted by OASIS users and TKM experts. It is made up 6 kinds of strategies such as core business model, data, meta-data and etc. Because this study has surveyed the TKM authoritative experts for the future plan of OASIS, it is significant study to get objective indices.
전통의학 정보포털 활성화를 위한 사용자 요구 분석에 관한 연구
예상준(Sangjun Yea),김하영(Hayoung Kim),김철(Chul Kim),김진현(Jinhyun Kim),김상균(Sangkyun Kim),장현철(Hyunchul Jang),송미영(Miyoung Song) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.2
Traditional Korean Medicine Information Portal OASIS has been upgraded continuously from the beginning of it's service. It builds up more contents and adds more functions to provide rich information for TKM's researcher. But it's improvement strategy is not systematic and not supported from objective data. So we did online survey and analyzed the results to get insight for improving and activating the OASIS. Also we compared the survey with the previous one conducted in 2009. From the analysis of survey, we can get the 4 results. First OASIS have aged users than young users. Second 39.0% users are using OASIS 2-3 times in a month. Third 18.8% users want OASIS to provide the conference paper in TKM. Finally 21.7% users want paper map analysis system. We must do information strategy planning to get the insight for the improvement. And this survey analysis result will be most important material to our planning. Also we will use this survey analysis result to satisfy the users' needs.
Graph SLAM을 통한 산악형 도심지역의 고정밀지도 작성 및 위치 인식 시스템에 대한 연구
김현우(Hyunwoo Kim),최윤중(YunJung Choi),강동완(DongWan Kang),김상준(SangJun Kim),길현준(HyunJun Gil),서주원(JuWon Seo),박선영(SunYoung Park),김재일(JaeIl Kim),임효진(HyoJin Lim),김정하(JungHa Kim) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11
This paper suggests a localization system architecture of unmanned vehicle for autonomous driving. In this system, Graph SLAM algorithm is used for correction of accumulated errors acquired from scan matching algorithm. On this paper, the experiments are proceeded in environment of mountainous city which have continuous elevations. The acceleration and magnetic data from IMU, RTK corrected GNSS are used for graph optimization and loop closure on mapping. NDT scan matching algorithm is used for localization.
라이다-카메라 캘리브레이션을 통한 동적 장애물 회피를 위한 자율주행 인지시스템에 대한 연구
김현우(Hyunwoo Kim),최윤중(YunJung Choi),김상준(SangJun Kim),길현준(HyunJun Gil),서주원(JuWon Seo),박선영(SunYoung Park),김재일(Jaell Kim),임효진(HyoJin Lim),김정하(JungHa Kim) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11
Sensor fusion area are known to great solution for the edge cases of perception system of automated car. This system uses camera and LiDAR on front side of the vehicle and integrated on a coordinate system for the projection. Each point data on image pixel integrated point cloud gets its class by semantic segmentation. This paper suggests a perception system of autonomous vehicle for moving objects by deep learning based image semantic segmentation and lidar points projection to camera pixel image.
자율주행 시스템의 Pure-pursuit 알고리즘을 이용한 Path Management 시스템 개발
최윤중(YunJung Choi),김현우(Hyunwoo Kim),신희석(HeeSeok Shin),김명준(MyeongJun Kim),김상준(SangJun Kim),길현준(HyunJun Gil),서주원(JuWon Seo),박선영(SunYoung Park),김재일(Jaell Kim),임효진(HyoJin Lim),김정하(JungHa Kim) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11
Research on autonomous vehicles consists of perception, judgement, and control. This paper is about the Ld method of the Pure-pursuit algorithm among the control algorithms based on the kinematic method in the control field. In the process of finding the correct L<SUB>d</SUB> for actual control, an error occurred between the detected L<SUB>d</SUB> value and the correct L<SUB>d</SUB>, and only a part of the path was detected L<SUB>d</SUB>. In order to store only the coordinates to be detected by LD in the path reference, the interval between paths was set very small, and the average interval and error of the detected LD values were calculated. The average interval and error of the detected LD value was proportional to the distance the sensor moved during the period of receiving a new signal, and accordingly, the path interval and path error were set appropriately. In the existing algorithm, the optimal interval and error are determined using the experimental data of the vehicle. The algorithm in this study may be less accurate than the existing algorithm. However, using only the target speed, the period of the sensor, and the minimum turning radius of the vehicle, it is possible to set the distance and the error of the path with high accuracy. Finally, the verification was carried out by directly controlling the autonomous vehicle.