Evaluation of Hot Deformation and Dynamic Recrystallization Behaviors of Advanced Reduced-Activated Alloy (ARAA)

Sang‑Wook Kim,Hyeon‑Woo Son,Taek‑Kyun Jung,Young‑Bum Chun,Yi‑Hyun Park,Ji‑Woon Lee,Soong‑Keun Hyun 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The hot deformation behavior of advanced reduced-activation alloy (ARAA) was investigated using hot torsion tests. Thefl ow stress decreased as deformation temperature increased and as strain rate decreased. The fl ow behavior demonstratedthe typical dynamic recrystallization (DRX). Based on the constitutive analysis of peak stress, the activation energy for hotdeformation was found to be 330.3 kJ mol −1 . Peak stress was analyzed as a function of the Zener–Hollomon parameter, andcalculated and experimental values were in good agreement. A DRX kinetic model for ARAA was derived with deformationconditions based on the Avrami-type model. It was confi rmed that the volume fraction of dynamically recrystallized grainsincreased as deformation temperature increased and as strain rate decreased. The necklace structure and grain boundarybulging were observed in the deformed microstructure of ARAA. The suggested DRX mechanism for ARAA during hotworking is discontinuous DRX.

Estimating Leaf Area Index of Paddy Rice from RapidEye Imagery to Assess Evapotranspiration in Korean Paddy Fields

Sang?Il Na,Suk Young Hong,Yi?Hyun Kim,Kyoung?Do Lee,So?Young Jang 한국토양비료학회 2013 한국토양비료학회지 Vol.46 No.4

Leaf area index (LAI) is important in explaining the ability of crops to intercept solar energy for biomass production, amount of plant transpiration, and in understanding the impact of crop management practices on crop growth. This paper describes a procedure for estimating LAI as a function of image?derived vegetation indices from temporal series of RapidEye imagery obtained from 2010 to 2012 using empirical models in a rice plain in Seosan, Chungcheongnam?do. Rice plants were sampled every two weeks to investigate LAI, fresh and dry biomass from late May to early October. RapidEye images were taken from June to September every year and corrected geometrically and atmospherically to calculate normalized difference vegetation index (NDVI). Linear, exponential, and expolinear models were developed to relate temporal satellite NDVIs to measured LAI. The expolinear model provided more accurate results to predict LAI than linear or exponential models based on root mean square error. The LAI distribution was in strong agreement with the field measurements in terms of geographical variation and relative numerical values when RapidEye imagery was applied to expolinear model. The spatial trend of LAI corresponded with the variation in the vegetation growth condition.

Natural bone-mimicking nanoporeincorporated hydroxyapatite scaffolds for enhanced bone tissue regeneration

Chansong Kim,Jin Woong Lee,허준혁,Cheolhyun Park,Dai-Hwan Kim,Gyu Sung Yi1,Ho Chang Kang,Hyun Suk Jung,Hyunjung Shin,Jung Heon Lee 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1

Background: A considerable number of studies has been carried out to develop alloplastic bone graft materials such as hydroxyapatite (HAP) that mimic the hierarchical structure of natural bones with multiple levels of pores: macro-, micro-, and nanopores. Although nanopores are known to play many essential roles in natural bones, only a few studies have focused on HAPs containing them; none of those studies investigated the functions of nanopores in biological systems. Method: We developed a simple yet powerful method to introduce nanopores into alloplastic HAP bone graft materials in large quantities by simply pressing HAP nanoparticles and sintering them at a low temperature. Results: The size of nanopores in HAP scaffolds can be controlled between 16.5 and 30.2 nm by changing the sintering temperature. When nanopores with a size of ~ 30.2 nm, similar to that of nanopores in natural bones, are introduced into HAP scaffolds, the mechanical strength and cell proliferation and differentiation rates are significantly increased. The developed HAP scaffolds containing nanopores (SNPs) are biocompatible, with negligible erythema and inflammatory reactions. In addition, they enhance the bone regeneration when are implanted into a rabbit model. Furthermore, the bone regeneration efficiency of the HAP-based SNP is better than that of a commercially available bone graft material. Conclusion: Nanopores of HAP scaffolds are very important for improving the bone regeneration efficiency and may be one of the key factors to consider in designing highly efficient next-generation alloplastic bone graft materials.

지역보건의료계획 수립에 있어 지역의료보험자료의 활용가능성

이상이,김철웅,문옥륜,Lee, Sang-Yi,Kim, Chul-Woung,Moon, Ok-Ryun 대한예방의학회 1997 예방의학회지 Vol.30 No.4

The health center has to play an important role in promoting community health and satisfying a variety of community health needs and demands in the decentralized Korea. The nearly enacted Community Health Act compels every health center to make its own health plans which intend to deal with local health problems and plan its future health care. This obligation is obviously a big burden to most health centers. They do not have experiences in and abilities of making local health care plans. In order to establish a systematic community health plan, health centers have to concentrate their efforts on enhancing the ability of making health care plan through gathering and analysing the local health informations. However, it is very difficult in reality. This is simply because it will take long time to accomplish these activities. It seems natural that various professionals and researchers participate in carrying out the process of making community health plan in the initial stage. No standardized methodology and analysing framework exist even in the health professional society. Nonetheless, it is common to introduce survey research methodologies in analysing consumer's health care utilization and cost, and in identifying factors influencing health behaviors. Many researchers and professionals have applied social survey methodologies in obtaining information on providers and health policy makers as well. The authors have found that few studies have ever utilized local health data stored at the self-employed medical insurance society as the data source of planning activities. The purpose of this study is to illustrate the usefulness of the data stored at the Sung-Dong Gu Self-employed Medical Insurance Society in establishing the community health plan. The major contents of this study are as follows ; 1. frequency of utilization by age, area, sex, type of medical care institutions, and some major diseases 2. Medical treatment by type of medical care institutions, by classification of 21 diseases, by frequency of three-character categories 3. Medical treatment of major neoplasm and some chronic diseases by age, sex, and area. The conclusion of this study is that it is of great potentiality to find out the local health problems and to use them in blueprinting the community health plan through comparing the frequency of medical utilization analyzed by a variety of variables with NHI health data or the health data from survey research.

한국 고인골에 남은 질병의 흔적

김명주(Kim, Myeung-Ju),김이석(Kim, Yi-Suk),이성준(Lee, Sung-Joon) 한국고대사학회 2021 韓國古代史硏究 Vol.- No.104

현재까지 많은 발굴조사가 실시되었으나, 시대별 또는 지역별로 유의미하게 활용할 수 있는 과거의 인체 정보는 미미하다. 이것은 연구 가능한 상태의 인골이 잔존하기 어려운 한국의 매장환경에 기인한 결과이겠지만, 고인골에 대한 의학적 연구가 폭넓게 진행되지 못했다는 점도 방증한다. 그럼에도 불구하고, 고고학과 의학의 융합연구는 다양한 가능성을 보여주었고, 대중적으로도 큰 주목을 받았다. 6세기 전후 사망한 창녕 송현동 15호분 출토 순장 인골, 7세기 전반에 사망한 익산 쌍릉 출토 인골, 16세기 후반 사망한 안동 가곡리 회곽묘 출토 미라, 17세기 중반 사망한 문경 진성이낭 묘 출토 미라 등이 좋은 사례이다. 그리고 다공성뼈과다증, 치아의 사기질저하증, 광범위특발성뼈과다증, 죽상동맥경화증, 복달렉탈장 등의 질병이 보고되었다. 과거의 사람과 삶을 복원하는 연구가 더욱 진전되기 위해서는 고고학과 의학 분야가 긴밀히 협업할 수 있는 체계가 마련되어야 한다. 앞으로 이와 같은 노력은 식생활, 질병(팬데믹), 이주 등 고대사회가 변동했던 역동적인 요인들을 규명하는 데 토대가 될 것이다. Although many excavations have been carried out, there is very little information about the human body in the past that can be used meaningfully. This is due to the burial environment in Korea, where it is difficult for human bones to remain in a researchable state, and it also proves that medical research on excavated human bones is insufficient. Nevertheless, the convergence researches of archeology and medicine showed various possibilities and received great attention from the public. Good examples are the human bones excavated from tomb no.5 of Songhyeon-dong in Changnyeong, who died around the 6th century, the human bones from Twin Tombs in Iksan, who died in the first half of the 7th century, the mummy from gagok-ri in Andong, who died in the late 16th century, and the mummy from Jinseong Yi’s tomb in Mungyeong, who died in the mid-17th century. And diseases such as porotic hyperostosis, enamel hypoplasia of tooth, diffuse idiopathic skeletal hyperostosis, and atherosclerosis were reported. In order to further advance the study of restoring people and lives in the past, a system in which archaeology and medicine can closely collaborate should be established. Such efforts will serve as a basis for identifying the factors that change ancient societies such as diet, disease (pandemic), and migration.

[CH-0005] The discovery of novel SNPs associated with group A soyasaponin biosynthesis from Korea soybean core collection

Sang-Beom Lee(Sang-Beom Lee),Soo-Kwon Park(Soo-Kwon Park),Kwang-Sik Lee(Kwang-Sik Lee),Hyun-Young Kim(Hyun-Young Kim),Dool-Yi Kim(Dool-Yi Kim),Mi-Suk Seo(Mi-Suk Seo),Soon-Chun Jeong(Soon-Chun Jeong),J 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

The Tissue Distribution and Overexpression of the Mouse Extracellular Superoxide Dismutase (EC-SOD) Gene in a Murine Cell Line, Pam212

Sang-Rae Lee,Seung-Hun Oh,Yoon-Yi Nam,Yang-Seok Oh,Tae-Yoon Kim,Jun-Gyo Suh 한국실험동물학회 2002 Laboratory Animal Research Vol.18 No.3

KR-31762, a Novel $K_{ATP}$ Channel Opener, Exerts Cardioprotective Effects by Opening $SarcK_{ATP}$ Channels in Rat Models of Ischemia/reperfusion-induced Heart Injury

Lee, Sung-Hun,Yang, Min-Kyu,Lim, Jong-Hyun,Seo, Ho-Won,Yi, Kyu-Yang,Yoo, Sung-Eun,Lee, Byung-Ho,Won, Hyung-Sik,Lee, Chang-Soo,Choi, Wahn-Soo,Shin, Hwa-Sup 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4

The cardioprotective effects of KR-31762, a newly synthesized $K^+_{ATP}$ opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. In isolated rat hearts subjected to 30-min global ischemia followed by 30-min reperfusion, KR-31762 (3 and 10 ${\mu}M$) significantly increased the left ventricular developed pressure (LVDP) and double product (heart rate ${\times}$ LVDP) after 30-min referfusion in a concentration-dependent manner, while decreasing the left ventricular end-diastolic pressure (LVEDP). KR-31762 also significantly increased the time to contracture (TIC) during ischemic period (20.0, 22.4 and 26.4 min for control, 3 and 10 ${\mu}M$, respectively), while decreasing the release of lactate dehydrogenase (LDH) from the heart during 30 min reperfusion (30.4, 14.3 and 19.7 U/g heart weight, respectively). All these parameters except LDH release were reversed by glyburide (1 ${\mu}M$), a nonselective blocker of $K^+_{ATP}$ channel, but not by 5-hydroxydecanoate, a selective blocker of $mitoK^+_{ATP}$ channel. In anesthetized rats subjected to 45-min occlusion of left anterior descending coronary artery followed by 90-min reperfusion, KR-31762 significantly decreased the infarct size (60.8, 40.5 and 37.8% for control, 0.3 and 1.0 mg/kg, iv, respectively). KR-31762 slightly relaxed the isolated rat aorta precontracted with methoxamine ($IC_{50}:\;23.5\;{\mu}M$). These results suggest that KR-31762 exerts potent cardioprotective effects through the opening of sarcolemmal $K_{ATP}$ channel in rat hearts with the minimal vasorelaxant effects.

Cardioprotective Effects of BMS-180448, a Prototype mitoK$_{ATP}$ Channel Opener, and the Role of Salvage Kinases, in the Rat Model of Global Ischemia and Reperfusion Heart Injury

Lee, Ju-Han,Jung, In-Sang,Lee, Sung-Hun,Yang, Min-Kyu,Hwang, Ji-Hye,Lee, Hak-Dong,Cho, Yu-Sun,Song, Min-Jin,Yi, Kyu-Yang,Yoo, Sung-Eun,Kwon, Suk-Hyung,Kim, Bo-Kyung,Lee, Chang-Soo,Shin, Hwa-Sup 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5

To investigate the involvement of reperfusion-induced salvage kinases (RISK) as possible signaling molecules for the cardioprotective effects of BMS-180448, a prototype mitochondrial ATP-sensitive K$^*$ (mitoK$_{ATP}$ ) channel opener, we measured its cardioprotective effects in a rat model of jschemia/reperfusion (1/R) heart injury, together with western blotting analysis of five different signaling proteins. in isolated rat hearts subjected to 30-min global ischemia followed by 30-min reperfusion, BMS-180448 (1, 3 and 10 K${\mu}$M) significantly increased reperfusion left ventricular developed pressure (LVDP) and 30-min reperfusion double product (heart rate x LVDP) in a concentration-dependent manner, while decreasing left ventricular end-diastolic pressure (LVEDP) throughout reperfusion period in a concentration-dependent manner. SDS-PAGE/western blotting analysis of left ventricle reperfused for 30 min revealed that BMS-180448 significantly decreased phospho-GSK3K${\beta}$ at high concentration, whereas it tended toincrease slightly phospho-eNOS and phospho-p70S6K with concentration. However, BMS-180448 had re effect on phospho-Akt and phospho-Bad. These results suggest that the car-dioprotective effects of BMS-180448 against 1/R heart injury may result from direct activation of mitoK$_{ATP}$ channel in cardiomyocytes, with the minimal role of RISK pathway in the activation of this channel and the cardioprotective effects of BMS-180448.

The Vascular Plant Species in the Korean Demilitarized zone (DMZ)

Lee, C.H.,Shin, H.T.,Kwon, Y.H.,Yi, M.H.,Yoon, J.W.,Kim, G.S.,Park, G.H.,Sung, J.W. Korean Biodiversity Information Facility 2013 Journal of Asia-Pacific Biodiversity Vol.6 No.1

The vascular plants identified in DMZ areas consist of 2,382 taxa: 159 families, 739 genera, 1,985 species, 11 subspecies, 306 varieties, 77 forma, and 3 hybrids. A total of 251 taxa were found to be rare plants in eastern area (172 taxa), central area (71 taxa), and western area (50 taxa). A total of 177 taxa were observed to be endemic plants in eastern area (109 taxa), central area (65 taxa), and western area (34 taxa). A total of 565 taxa were identified to be the floristic special plants, which were divided into five classes: class I (173 taxa), class II (87 taxa), class III (153 taxa), class IV (121 taxa), and class V (31 taxa). The identified taxa surveyed in eastern, central, and western area were 450, 232, and 159 taxa respectively. A total of 134 naturalized plants were recorded, and the naturalization rate and urbanization rate were identified as 5.6% and 41.7% respectively. 80 taxa were observed in eastern area, of which naturalization rate was 6.8% and urbanization rate was 24.9%. 84 taxa were recorded in central area, of which naturalization rate was 6.8% and urbanization rate was 26.1%. Finally, 54 taxa were observed in western area, of which naturalization rate was 5.1% and urbanization rate was 16.8%.