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( Sang Yu Oh ),( Bo Ryung Park ),( Byung Uk Lee ),( Jae Ho Park ),( Byung Gyu Kim ),( Seok Won Jung ),( In Du Jeong ),( Sung-jo Bang ),( Jung Woo Shin ),( Neung Hwa Park ),( Yun Im Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Rare data are available on the comparison of tenofovir (TDF) and entecavir (ETV) therapy in chronic hepatitis B patients with baseline high viral load (HVL) in clinical practice, defined as having hepatitis B virus (HBV) DNA >8 log10 copies/mL (7.3 log10 IU/mL). Methods: We performed a retrospective analysis of the efficacy of TDF therapy, as compared to that of ETV therapy, in patients with HVL. A matched study population was constructed to compare the antiviral efficacy of TDF therapy and ETV therapy by a propensity score analysis. Results: Three hundreds two patients were selected after matching propensity score with 1:1 ratio. Virologic response (VR) was observed in 63.6% (96/151) of patients in the TDF group and in 64.2% (97/151) of the patients in the ETV group. The VR rates were not different between the TDF and ETV groups (51.5 vs. 51.4% at month 12, and 72.1 vs. 69.2% at month 24; log rank P = 0.432). During therapy, 70.2% of patients in the TDF group, and 74.8% of patients in the ETV group had partial VR, respectively (P=0.367). ALT normalization rates also did not differ between both the treatment groups (94.3% and 92.1% in the TDF and ETV therapy groups, respectively; P = 0.838). Nineteen patients experienced a virological breakthrough. Among them, 7 patients (4.6 %) was in the TDF group and 12 patients (7.9 %) were in the ETV group (P = 0.236). During therapy, 21.2% (28 of 132) of patients in the TDF group, and 19.1% (25 of 131) of patients in the ETV group achieved HBeAg seroconversion, respectively (P = 0.667). In multivariate analysis, absolute HBV DNA level at baseline (P<0.001), HBeAg-positive status (P< 0.001) and ALT levels at baseline (P =0.044) were significantly associated with VR. Conclusions: In patients with HVL >8 log10 copies/mL (7.3 log10 IU/mL), virological and biochemical responses were similar between ETV and TDF therapy groups in CHB patients. Therefore, either ETV or TDF are recommended to use as the first-line nucleoside analogues in patients with HVL..
Lee, Je-Ryung,Jeon, Eun-chae,Kim, Hwi,Woo, Sang-Won,Je, Tae-Jin,Yoo, Young-Eun,Lee, Eung-Sug Korean Society for Precision Engineering 2015 International Journal of Precision Engineering and Vol.16 No.7
The use of an optical plate to enhance light efficiency of LED systems was suggested. The optical plate technology indicates that polymeric optical plates having optical patterns on themselves are placed on LED systems. We designed and manufactured an optical plate that enhance light efficiency, and verified its optical characteristics in this study. The shape and the size of the spherical lens patterns were designed based on the lens formula including the refraction indices of air and PMMA, thickness of the optical component and the optical distance. To manufacture the optical plate having the designed spherical lens patterns, a metal mold was machined by ultra-fine punching machining technology. Using the ultra-fine punching machining system, spherical lens patterns with 0.45 mm in height, 1.15 mm in diameter were successfully machined on the top of a mold of 90 * 60 mm2 size. Using the machined mold and transparent PMMA, an optical plate with the spherical lens patterns was molded by injection molding technology. The optical plate was placed on the LED system, and the luminance was measured with and without the optical plate, and as a result the average and the maximum intensity increased by 1.4 times and 1.3 times respectively.
Clinical factors indicating nail unit melanoma in longitudinal melanonychia patients
( Sang Gyun Lee ),( Mi Ryung Roh ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1
Background: Longitudinal melanonychia (LM) is a common symptom, but nail unit melanoma (NUM) must always be considered as a differential diagnosis. It is important to clinically distinguish NUM from benign LM for a more targeted biopsy strategy. Objectives: To identify factors indicating NUM in patients presenting with LM. Methods: This was a retrospective cohort study of 145 patients who presented with LM from January 2005 to March 2021. Patients were considered benign if the lesion did not necessitate a biopsy during the clinical course, or was confirmed on biopsy. Patients’ clinical photographs were retrospectively reviewed, then predicting factors for NUM were identified by logistic regression models. Because Hutchinson sign is a well-known and obvious indicator, a multivariable model excluding it was also made. Results: Among the 145 patients, 48 were confirmed as NUM. On the univariable logistic regression model, age, intensity, color, variegation, width, nail plate splitting, Hutchinson sign, recent change were statistically significant predictive factors for NUM. On the multivariable model by stepwise selection, variegation and Hutchinson sign were significant. When Hutchinson sign was excluded, intensity, variegation and recent change were significant. Conclusion: Color intensity, variegation, recent change, and Hutchinson sign are important clinical factors indicating NUM in LM patients.
Sung-Su Kim,Soo-Hyun Park,Jae-Ryung Lee,Jun-Sub Jung,Hong-Won Suh 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.5
The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN; 0.6 g/10 ml)/lipopolysaccharide (LPS; 27 µg/27 µl) was treated intraperitoneally (i.p.). The i.t. pretreatment with clonidine (5 µg/5 µl) increased the blood glucose level and attenuated mortality induced by sepsis in a dose-dependent manner. The i.t. post-treatment with clonidine up to 3 h caused an elevation of the blood glucose level and protected sepsis-induced mortality, whereas clonidine post-treated at 6, 9, or 12 h did not affect. The pre-treatment with oral D-glucose for 30 min prior to i.t. post-treatment (6 h) with clonidine did not rescue sepsis-induced mortality. In addition, i.t. pretreatment with pertussis toxin (PTX) reduced clonidine-induced protection against mortality and clonidine-induced hyperglycemia, suggesting that protective effect against sepsis-induced mortality seems to be mediated via activating PTX-sensitive G-proteins in the spinal cord. Moreover, pretreatment with clonidine attenuated the plasma tumor necrosis factorα (TNF-α) induced by sepsis. Clonidine administered i.t. or i.p. increased p-AMPKα1 and p-AMPKα2, but decreased p-Tyk2 and p-mTOR levels in both control and sepsis groups, suggesting that the up-regulations of p-AMPKα1 and p-AMPKα2, or down-regulations of p-mTOR and p-Tyk2 may play critical roles for the protective effect of clonidine against sepsis-induced mortality.
A case of rapidly progressive cutaneous squamous cell carcinoma arising from an epidermal cyst
( Sang Gyun Lee ),( Seung-ju Lee ),( Mi Ryung Roh ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Epidermal cysts are common cysts that present on the head, neck and upper trunk. The clinical course is thought to be benign, but rarely, malignancies such as squamous cell carcinoma (SCC) have been reported to arise from these cysts. Such malignant transformation is rare, with reported rates ranging from 0.011 % to 0.045 %. In most cases, complete surgical excision is curative, but there have been reports of highly aggressive metastatic disease causing mortality. A 31-year-old female presented with an enlarging subcutaneous nodule on the anterior chest. The nodule was excised at a local clinic, but when pathology showed an epidermal cyst with SCC, she was referred to our hospital. Mohs micrographic surgery was performed on the residual nodule. Over the next 7 months, multiple local recurrences occurred, requiring three additional surgeries. After the last surgery, she complained of a left axilla mass. PET-CT was done, on which axillary lymph node metastases were found, which was later confirmed by biopsy. Tissue human papillomavirus PCR was negative, and Next Generation Sequencing revealed TP53 mutation and ALK fusion. She underwent clinical trial of talimogene laherparepvec and intravenous pembrolizumab, but after the 1st treatment, disease progressed rapidly, with peritoneal carcinomatosis causing ileus. She is currently under conservative care. Here, we present an alarming case of a very aggressive SCC arising from an epidermal cyst.
Lee, Dongki,Sin, Dong Hun,Kim, Sang Woo,Lee, Hansol,Byun, Hye Ryung,Mun, Jungho,Sung, Woong,Kang, Boseok,Kim, Dae Gun,Ko, Hyomin,Song, Sung Won,Jeong, Mun Seok,Rho, Junsuk,Cho, Kilwon American Chemical Society 2017 Macromolecules Vol.50 No.21
<P>We fabricated hybrid poly(3-hexylthiophene) nano fibers (P3HT NFs) with rigid backbone organization through the self-assembly of P3HT tethered to gold NPs (P3HT-Au NPs) in an azeotropic mixture of tetrahydrofuran and chloroform. We found that the rigidity of the P3HT chains derives from the tethering of the P3HT chains to the Au NPs and the control of the solubility of P3HT in the solvent. This unique nanostructure of hybrid P3HT NFs self-assembled in an azeotropic mixture exhibits significantly increased delocalization of singlet (S-1) excitons compared to those of pristine and hybrid P3HT NFs self assembled in a poor solvent for P3HT. This strategy for the self-assembly of P3HT-Au NPs that generate long-lived S1 excitons can also be applied to other crystalline conjugated polymers and NPs in various solvents and thus enables improvements in the efficiency of optoelectronic devices.</P>
FC 1-11 : Clinical factors indicating nail unit melanoma in longitudinal melanonychia patients
( Sang Gyun Lee ),( Mi Ryung Roh ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-
Background: Longitudinal melanonychia (LM) is a common symptom, but nail unit melanoma (NUM) must always be considered as a differential diagnosis. It is important to clinically distinguish NUM from benign LM for a more targeted biopsy strategy. Objectives: To identify factors indicating NUM in patients presenting with LM. Methods: This was a retrospective cohort study of 145 patients who presented with LM from January 2005 to March 2021. Patients were considered benign if the lesion did not necessitate a biopsy during the clinical course, or was confirmed on biopsy. Patients’ clinical photographs were retrospectively reviewed, then predicting factors for NUM were identified by logistic regression models. Because Hutchinson sign is a well-known and obvious indicator, a multivariable model excluding it was also made. Results: Among the 145 patients, 48 were confirmed as NUM. On the univariable logistic regression model, age, intensity, color, variegation, width, nail plate splitting, Hutchinson sign, recent change were statistically significant predictive factors for NUM. On the multivariable model by stepwise selection, variegation and Hutchinson sign were significant. When Hutchinson sign was excluded, intensity, variegation and recent change were significant. Conclusion: Color intensity, variegation, recent change, and Hutchinson sign are important clinical factors indicating NUM in LM patients.