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The role of Egr-1 in IL-17F-induced psoriasin expression in human keratinocytes
( Sang Hoon Jeong ),( Min Gun Yoo ),( Seong Kyu Jeong ),( San Geun Lee ),( Hee Hoo Kim ),( Kyung Goo Lee ),( Sang Min Yi ),( Eun Young Lee ),( Yoon Hee Park ),( Hyun Cheol Bae ),( Sang Wook Son ) 대한피부과학회 2011 초록집 Vol.49 No.20
Bae, Hoon,Kim, Hak-Sung The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.8
Coumarin and its derivatives occur widely in nature. Many attempts were made for synthesis of various coumarin derivatives because of their interesting biological activities. In this study, solid phase synthetic approach of 3-(4-hydroxyphenyl)coumarin was achieved for combinatorial synthesis of substituted 3-phenylcoumarin analogues. Starting from 4-hydroxyphenylacetic acid methyl ester, release of 3-(4-hydroxypnehyl)coumarin from polymer support was accom-plished.
( Sung Hoon Lee ),( Jin Young Lee ),( Il Hong Bae ),( Jun Cheol Cho ),( Hae Kwang Lee ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
The skin epidermal barrier protects the body against excessive water loss and the invasion of harmful substances, including chemicals and microbes. Skin barrier can be damaged by several external stimuli such as UV irradiation, humidity and temperature. The destruction of skin barrier is associated with cosmetic problem and skin diseases. Skin equivalent model has epidermal layer and stratum corneum, therefore, it can be used for skin barrier function study that is difficult to test in mono-layer culture system. In order to assess the influence of skin barrier against UV irradiation and low humidity, we employed a skin equivalent model (AmoReSkinTM). UVB irradiation induced a destruction of tight junction (TJ) components in skin equivalents. TJ permeability barrier was disrupted by UVB irradiation. Based on the fact that bicationic minerals such as calcium and magnesium are known to protect the skin barrier, we examined the efficacy of mineral water in this regard. The results of TJ permeability assay showed that mineral water helped to maintain the TJ permeability barrier after the application of UVB-irradiation to skin equivalents. To investigate the function of environmental humidity, skin equivalents were incubated at different humidity conditions. Skin equivalents were incubated at normal 80% RH and low 60% RH for 4 days. Unlike the skin equivalents incubated at 80% RH, skin equivalents could not grow normally at 60% RH. Mineral water protects the skin equivalent cultured at low humidity. In skin equivalents, UV irradiation and low humidity influenced the skin barrier. And the protective effect of mineral water was identified. Further study to elucidate the protective mechanism and correlation between human skin and skin equivalents can be beneficial to understand skin barrier.