PER3, a novel target of miR-103, plays a suppressive role in colorectal cancer in vitro

( Zhang Hong ),( Zhang Feng ),( Zhang Sai ),( Su Tao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.9

Colorectal cancer has become the third most common cancerand leads to high mortality worldwide. Although colorectalcancer has been studied widely, the underlying molecularmechanism remains unclear. PER3 is related to tumordifferentiation and the progression of colorectal cancer. Highexpression of miR-103 is associated with poor prognosis inpatients with colorectal cancer. However, the relationshipbetween miR-103 and PER3 in CRC cells remains unclear. Inthis study, we found that PER3 was downregulated in CRC tissues and CRC cell lines, whereas miR-103 was upregulatedin CRC cell lines. We also found that PER3 promoted CRCcells apoptosis. These results indicate that PER3 plays asuppressive role in CRC cells. Moreover, we found that PER3was targeted, at least partially, by miR-103. Taken together, weprovide evidence to characterize the role of PER3 in CRC, which may be a new therapeutic target for CRC.

The influence of soil aggregation induced by water content variation on the engineering behaviors of cement-treated silt subgrade

Sai Zhang,Jian-Wen Ding,Zhenyuan Lai,Qinying Guo,Xing Wan 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.10

Water content is an important indicator of highway subgrade compaction, which has an impact on the engineering behaviors of pavement structures significantly. To study the influence of soil aggregation induced by water content variation on the engineering behaviors of silt subgrade, a series of laboratory experiments, including sieving analysis, unconfined compression tests and hydraulic conductivity tests, were conducted on the cement-treated silt subgrade. The influence of water content on the soil aggregation, unconfined compressive strength (UCS) and hydraulic conductivity were examined, respectively. The distribution range of UCS index (IUCS) and hydraulic conductivity index (Ik) were expressed accordingly. Test results demonstrate that when the water content lower than the optimum water content (wopt), the specimens are more homogeneous, the UCS increases regularly with the increase of curing time and water content, the hydraulic conductivity decreases regularly with curing time and water content increased. When the water content is higher than the wopt, the silt aggregation leads to the structural inhomogeneity of specimens, the strength decreases irregularly with the increase of curing time and water content, the hydraulic conductivity increases irregularly with the increase of curing time and water content accordingly. The soil aggregation induced by water content variation is proved to be a major reason for the ununiformly distribution of the UCS and hydraulic conductivity, the influence of which is more significant than that of binders when the water content higher than the wopt. Hence, controlling water content within 2% lower the wopt is strongly suggested to forming a more homogeneous structure of the subgrade.

Korea and Japan trade friction and its impact on China’s semiconductor industry

ZHANG SAI(장세) 한국산업경제학회 2019 한국산업경제학회 정기학술발표대회 논문집 Vol.2019 No.12

Synthesis of Trilaminar Core–Shell Au/α-Fe2O3@SnO2 Nanocomposites and their Application for Nonenzymatic Dopamine Electrochemical Sensing

Sai Zhang,Shijun Yue,Jiajia Li,Jian-Bin Zheng,Guojie Gao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.11

Au nanoparticles anchored on core–shell α-Fe2O3@SnO2 nanospindles were successfully constructed through hydrothermal synthesis process and used for fabricating a novel nonenzymatic dopamine (DA) sensor. The structure and morphology of the Au/α-Fe2O3@SnO2 trilaminar nanohybrid film were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The electrochemical properties of the sensor were investigated by cyclic voltammetry and amperometry. The experimental results suggest that the composites have excellent catalytic property toward DA with a wide linear range from 0.5 μM to 0.47 mM, a low detection limit of 0.17 μM (S/N = 3) and high sensitivity of 397.1 μA mM -1 cm -2. In addition, the sensor exhibits long-term stability, good reproducibility and anti-interference.

노년층의 전자 개인 건강 기록(ePHR) 시스템 UI/UX 요소 선호에 관한 실증 연구-원격 문진표 인터페이스 개발을 중심으로-

장새난(Zhang, Sai Nan),송지성(Song, Jisung) 한국디자인문화학회 2023 한국디자인문화학회지 Vol.29 No.4

With the advent of digital technology, the significance of Electronic Personal Health Records (ePHR) in the medical sector is increasingly becoming salient. ePHRs comprehensively document medical information, medication prescriptions, and health indices prior to treatment. Such systems are evaluated to provide end users with expanded control over health data and convenience. However, a preponderance of system interface designs is youth-centric, thereby lacking consideration for the elderly demographic. This results in varied challenges experienced by older individuals in utilizing these systems. Given the unique technological utilization characteristics of the elderly, understanding their preferences regarding ePHR system design is of paramount importance. This study investigated the needs and preferences of elderly individuals concerning online medical questionnaire interface design through Conjoint Analysis. Adhering to UX design principles, five primary factors were measured: “platform, color combination, icon design style, page layout, and navigation menu”, utilizing Orthogonal Design through SPSS to form a variety of attribute and factor level combinations, thereby generating eight representative design combinations. High-fidelity models were developed using Figma, followed by a survey conducted among 164 elderly individuals to gauge the preferences concerning design models. The outcomes of this study, obtained through this process, are as follows. Firstly, among the attributes of online medical questionnaire interface design, elderly individuals considered color combinations as the most prioritized attribute, followed by icon design style, and subsequently, the navigation menu. These findings are anticipated to elucidate the ideal combination of ePHR UI UX elements for the elderly and provide insightful information concerning online medical questionnaire interface design. Additionally, it enables the provision of more tailored services to the elderly demographic. Identifying the ideal composition of UI UX elements for online medical questionnaires aimed at the elderly provides invaluable insights into the interface design of ePHR systems. Moreover, it aids in the extensive promotion of mobile health medical services within elderly communities, and is expected to further enhance the user interface usage experience of elderly individuals in managing their health.

전자 폐기물 회수 로봇 개발을 위한 사용자 중심 서비스 디자인 방향성 제안

장새난(Sai Nan Zhang),송지성(Ji Sung Song) 한국디자인리서치학회 2023 한국디자인리서치 Vol.8 No.4

전자 폐기물 처리는 환경 지속 가능성 발전의 도전 중 하나이다. 이 연구는 H 대학 캠퍼스 내에서 이러한 문제가 된 개선의 필요성을 발견하였으며, 문헌 및 사례 조사와 이해당사자 요구분석을 통해 현재 주요 문제점을 파악하였다. 학생, 교직원, 캠퍼스 환경미화원을 대상으로 설문조사와 심층 인터뷰를 진행하였다. “심리스 집적” “적응 학습“” 지식 보급“ ”참여 독려”의 디자인 콘텐츠를 식별하였다. ICT 기반의 캠퍼스 전자 폐기물 회수 시스템을 도입하여 캠퍼스에서 전자 폐기물 처리 서비스 효율성을 향상하는 것을 목표로 한다. 사용자 중심으로 각 이해당사자들의 경험을 서비스 디자인 방향을 제안하였다. 딥 러닝 모델을 기반으로 ICT 전자 폐기물 회수 로봇은 H 대학 캠퍼스 전자 폐기물 회수 서비스 과정에서 효과적인 실행 가능성이 있다는 것을 연구 결과를 도출하였다. 캠퍼스 내에서 발생하는 전자 폐기물의 효과적인 회수를 위한 혁신적인 해결책을 제공이 되기를 기대한다. The management of electronic waste represents a challenge in the advancement of environmental sustainability. At H University's campus, the necessity for improvement in this area has been identified, with major issues being pinpointed through literature and case studies, as well as stakeholder needs analysis. Surveys and in-depth interviews were conducted with students, faculty, and campus janitorial staff. The research identified design contents The goal is to enhance the efficiency of electronic waste disposal services on campus through the introduction of an ICT-based e-waste collection system. A service designt, based on deep learning models, in effectively implementing e-waste collection services at H University. This research provides innovative solutions for the effective collection of e-waste generated on campus.

아프리카 전자상거래 법률 및 규정이 중국과 아프리카의 디지털 무역에 미치는 영향 분석

장새(Sai Zhang),조국봉(Guofeng Zhao) 한국정치사회연구소 2023 한국과 국제사회 Vol.7 No.4

KANO+QFD 모델을 기반으로 IoT 반려묘 음수기의 디지털 터미널 디자인 방향 제안

장새난(Sai Nan Zhang),이의범(Yi Fan Li),리메이르(Mei Le Le) 한국디자인리서치학회 2024 한국디자인리서치 Vol.9 No.2

최근 반려동물용품 시장이 점차 확대되고 있다. 특히 사용자의 요구가 단순한 관심에서 경험과 감정적 요구로 전환되면서 지능형 IoT 기반 반려동물 관리 제품에 대한 수요도 계속해서 증가하고 있다. 따라서 본 연구에서는 현재 시장의 반려동물 음수기가 기본적인 기능에만 초점을 맞출 뿐 사용자 경험 디자인을 소홀히 하는 문제를 해결하고자 하였다. 본 연구는 먼저 사용자 여정 지도를 구축하여 사용자가 모바일 및 IoT음수기와 상호작용 시 행동 경로를 분석함으로써 사용자의 요구를 도출하였다. 이어서 KANO 모델을 토대로 사용자 만족도와 요구 사항의 중요도에 대한 정성적 분석을 실시하여 요구 사항의 우선순위를 결정하고, 품질 기능 배치(QFD) 도표를 구축하여 디자인 요구 사항의 중요성을 분석하고 정량화하였다. 연구 결과 ‘음수량 통계 디자인’에 대한 요구 사항과 ‘수질 모니터링 피드백 디자인’에 대한 요구 사항의 중요도 가중치가 가장 높은 것으로 나타나 디지털 종단 시스템 디자인 과정에서의 핵심 디자인 요구 사항이 됨을 보여주었다. 이를 토대로 본 연구는 KANO와 QFD 모델을 결합해 IoT 스마트 음수 시스템 플랫폼 디자인 방향을 제안하였다. 또한 사용자 요구의 관점에서 반려묘 IoT 음수기의 원격 사용자 종단 시스템 디자인에 대한 방향성을 제공하였다. The pet supplies market is witnessing a gradual expansion, with a particularly notable increase in demand for intelligent IoT-based pet management products. In this context, consumer demands are shifting from mere interest to desires for experiences and emotional engagements. This study aims to address the prevalent issue in the current market where the majority of pet water dispensers focus solely on basic functionalities, neglecting deep user experience design. The research begins by constructing a user journey map to analyze the behavioral paths of users interacting with mobile and IoT water dispensers, thereby deriving user needs. Subsequently, a qualitative analysis based on the Kano model is conducted to determine the priorities of user satisfaction and requirements, and a Quality Function Deployment(QFD) chart is developed to analyze and quantify the importance of design requirements. The findings indicate that the importance weights of water intake statistics design requirements and water quality monitoring feedback design requirements are the highest, becoming key design considerations in the digital end-to-end system design process. Therefore, this study proposes a design direction for the IoT smart drinking system platform through the combined application of the Kano and QFD models, offering guidance on the remote user end system design for IoT pet water dispensers from a user needs perspective.

Enrichment of valuable elements from vanadium slag using superconducting HGMS technology

Sai He,hang-qiaoYang,Su-qin Li,Chang-quan Zhang 한국초전도저온학회 (구 한국초전도저온공학회) 2017 한국초전도저온공학회논문지 Vol.19 No.1

Study of a hybrid modular exhaust turbocharging system and its application on an 8-cylinder marine diesel engine

Kun Zhang,Xinyu Huang,Sai He,Kangyao Deng,Yi Cui,Aiqiang Luo 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.6

For turbocharging engines, the structure of the exhaust system directly affects the flow and energy transfer process of the exhaust gas, which has a big influence on the turbocharger performance. To evaluate the performance of various kinds of exhaust systems, two indicators, “available energy loss coefficient” and “pressure wave interference coefficient”, are proposed to evaluate the steady flow loss and transient flow anti-interference characteristics. Two kinds of exhaust system modular, Modular pulse converter (MPC) and Modular multi-purpose pulse converter (MMPC), are analyzed and compared by the three-dimensional calculation. The results show that the MMPC structure has a smaller available energy loss and a better anti-interference performance in the exhaust process. To solve the problems of scavenging interferences and exhaust temperature discrepancy on a highly boosted 8-cylinder marine diesel engine, a Hybrid modular exhaust (HME) system is proposed. Effects of MMPC, HME and MIXPC (Mixed pulse converter) on the engine performance are compared by one-dimensional simulation. This is followed by an engine test for performance comparison between MMPC and HME, which shows that the HME system can effectively relieve the problems of scavenging interference, and the maximum exhaust temperature discrepancy of all cylinders is reduced from 60°C to 31°C under the rated condition.