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Sungwoo Jung,Jin Ho Lee,이형순 대한내시경로봇외과학회 2023 Journal of Minimally Invasive Surgery Vol.26 No.3
Purpose: Robotic hernia repair has increased in popularity since the introduction of da Vinci robots (Intuitive Surgical). However, we lack quantitative analyses of its potential benefits. Herein, we report our initial experience with robotic transabdominal preperitoneal (R-TAPP) inguinal hernia repair. Methods: We retrospectively reviewed the data from patients who underwent R-TAPP inguinal hernia repair with a prosthetic mesh using the da Vinci platform. Data on patient characteristics and surgical outcomes were also collected. Results: Twenty-one patients (including 20 male patients [95.2%]) with a mean age of 54.1 ±16.4 years and body mass index of 23.8 ± 1.9 kg/m2 underwent R-TAPP inguinal hernia repair. Bilateral hernia repair was performed in two patients (9.5%), and six patients (28.5%) with scrotal hernia underwent R-TAPP hernia repair. A sigmoid colon sliding hernia was present in three patients (14.3%). The mean operation and console times were 91.8 ± 20.4 minutes and 154.5 ± 26.2 minutes, and 61.4 ± 16.9 minutes and 128.0 ± 25.5 minutes for unilateral and bilateral inguinal hernia, respectively. Spermatic vessel injury was identified intraoperatively in one patient. Two minor postoperative complications, postoperative ileus, and wound seroma were reported. The mean duration of hospitalization was 3.8 ± 0.9 days. No recurrence or conversion to open surgery was required. Conclusion: Our findings suggest that R-TAPP inguinal hernia repair is safe and feasible. Its cost-effectiveness, optimal procedural steps, and indications for a robotic approach require further investigation.
Sungwoo Jung,Jin Ho Lee,정재욱,Hyung Soon Lee 대한내시경복강경외과학회 2022 Journal of Minimally Invasive Surgery Vol.25 No.1
Serious complications related to hernia surgeries have rarely been reported. One meta-analysis comparing laparoscopic and open mesh repair reported that 0.4% of potentially serious operative complications were reported. Previous studies have reported that uncommon serious intraoperative complications more frequently occur during laparoscopic inguinal hernia repairs. One study has shown that patients with history of lower abdominal surgery are at an increased risk of visceral injury during laparoscopic hernia repair. Vascular injuries at dissection and mesh fixation or suturing in the preperitoneal space typically involve the epigastric or aberrant obturator vessels crossing the Cooper’s ligament. However, complications can occur at every step of the operation, although only few are reported. Therefore, we report our experiences of intraoperative complications during single-incision laparoscopic totally extraperitoneal hernia repair and how to prevent and manage intraoperative complications.
Robotic transabdominal preperitoneal repair for bilateral obturator hernia: a video vignette
Sungwoo Jung,Hyung Soon Lee 대한내시경로봇외과학회 2024 Journal of Minimally Invasive Surgery Vol.27 No.1
Obturator hernias (OHs) are a rare cause of bowel obstruction that requires immediate surgical intervention to prevent morbidity and mortality. Patients with OHs present with acute intestinal obstruction secondary to incarceration, with a high morbidity and mortality rate due to delayed diagnosis and treatment. Although several surgical approaches have been reported, a standard approach for OH treatment has not yet been established. Here, we report the case of a 74-year-old woman who presented with bilateral OHs. The patient presented at our institution with pain in the left lower quadrant. Computed tomography revealed preperitoneal fat in both obturator foramen. Robotic transabdominal preperitoneal (R-TAPP) bilateral OH repair was performed, and a mesh was placed over both obturator foramen. The patient recovered without postoperative complications and was discharged on postoperative day 2. This suggests that the R-TAPP approach is safe for OH repair without incarceration.
HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer
Park, Jung Hee,Jung, Kyung Hee,Kim, Soo Jung,Yoon, Young-Chan,Yan, Hong Hua,Fang, Zhenghuan,Lee, Ji Eun,Lim, Joo Han,Mah, Shinmee,Hong, Sungwoo,Kim, You-Sun,Hong, Soon-Sun Elsevier 2019 Cancer letters Vol.444 No.-
<P><B>Abstract</B></P> <P>Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting kinase 3 (RIP3). Recently, necroptosis has gained attention as a novel alternative therapy to target cancer cells. In this study, we screened several chemotherapeutics used in preclinical and clinical studies, and identified a drug HS-173 that induces RIP3-mediated necroptosis. HS-173 decreased the cell survival in a dose-dependent manner in RIP3-expressing lung cancer cells, compared to the cells lacking RIP3. Also, the cell death induced by HS-173 was rescued by specific necroptosis inhibitors such as necrostatin-1 and dabrafenib. Additionally, HS-173 increased the phosphorylation of RIP3 and MLKL, which was decreased by necroptosis inhibitors, indicating that HS-173 activates RIP3/MLKL signaling in lung cancer cells. HS-173 increased the necroptotic events, as observed by the increased levels of HMGB1 and necroptotic morphological features. Furthermore, HS-173 inhibited the tumor growth by stimulation of necroptosis in mouse xenograft models. Our findings offer new insights into the role of HS-173 in inducing necroptosis by enhancing RIP3 expression and activating the RIP3/MLKL signaling pathway in lung cancer cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Necroptosis is a novel alternative therapy to target cancer cells. </LI> <LI> HS-173 induced necroptosis in lung cancer cells by enhancing the expression of RIP3 and activating RIP3/MLKL signaling pathway. </LI> <LI> The necroptotic events induced by HS-173 has been observed by the increased levels of HMGB1 and necroptotic morphological features. </LI> <LI> HS-173 inhibited the tumor growth by stimulation of necroptosis in mouse xenograft models. </LI> <LI> Our findings offer new insights into the role of HS-173 on inducing necroptosis through RIP3 activation in lung cancer cells. </LI> </UL> </P>
Kim Youn-Jung,Hong Jung Seok,Hong Seok-In,Kim June-Sung,Seo Dong-Woo,Ahn Ryeok,Jeong Jinwoo,Lee Sung Woo,Moon Sungwoo,Kim Won Young 대한의학회 2021 Journal of Korean medical science Vol.36 No.25
Background: Inter-hospital transfer (IHT) for emergency department (ED) admission is a burden to high-level EDs. This study aimed to evaluate the prevalence and ED utilization patterns of patients who underwent single and double IHTs at high-level EDs in South Korea. Methods: This nationwide cross-sectional study analyzed data from the National Emergency Department Information System for the period of 2016–2018. All the patients who underwent IHT at Level I and II emergency centers during this time period were included. The patients were categorized into the single-transfer and double-transfer groups. The clinical characteristics and ED utilization patterns were compared between the two groups. Results: We found that 2.1% of the patients in the ED (n = 265,046) underwent IHTs; 18.1% of the pediatric patients (n = 3,556), and 24.2% of the adult patients (n = 59,498) underwent double transfers. Both pediatric (median, 141.0 vs. 208.0 minutes, P < 0.001) and adult (median, 189.0 vs. 308.0 minutes, P < 0.001) patients in the double-transfer group had longer duration of stay in the EDs. Patient's request was the reason for transfer in 41.9% of all IHTs (111,076 of 265,046). Unavailability of medical resources was the reason for transfer in 30.0% of the double transfers (18,920 of 64,054). Conclusion: The incidence of double-transfer of patients is increasing. The main reasons for double transfers were patient's request and unavailability of medical resources at the firsttransfer hospitals. Emergency physicians and policymakers should focus on lowering the number of preventable double transfers.
정상훈(Sanghun Jung),이성옥(Seongok Lee),전성우(Sungwoo Jeon),정회경(Heokyung Jung) 한국정보통신학회 2021 한국정보통신학회 종합학술대회 논문집 Vol.25 No.2
메타버스는 코로나 19 펜데믹과 더불어 폭발적으로 성장하는 분야이다. 다만, 메바터스의 기존 개념에서 오인되거나 새로운 것이 나타난 것이 아님을 여러 사례에서 살펴 볼 수 있다. 향후 전개될 메타바서스 시대에 본고와 같은 시각의 접근이 도움이 되길 바란다. Metaverse is a field that is growing explosively along with the COVID-19 pandemic. However, it can be seen from several cases that the existing concept of Mebatus is not misunderstood or that a new one has not appeared. It is hoped that an approach similar to this article will be helpful in the metavassus era to be developed in the future.