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Ji-Won Baick,Jang-Ho Yoon,Suk Namgoong,Dieter S?l,Sung-Il Kim,Soo-Hyun Eom,Kwang-Won Hong 한국미생물학회 2004 The journal of microbiology Vol.42 No.2
It is known that Bacillus subtilis glutamyl-tRNA synthetase (GluRS) mischarges E. coli tRNA1 Gln with glutamate in vitro. It has also been established that the expression of B. subtilis GluRS in Escherichia coli results in the death of the host cell. To ascertain whether E. coli growth inhibition caused by B. subtilis GluRS synthesis is a consequence of Glu-tRNA1 Gln formation, we constructed an in vivo test system, in which B. subtilis GluRS gene expression is controlled by IPTG. Such a system permits the investigation of factors affecting E. coli growth. Expression of E. coli glutaminyl-tRNA synthetase (GlnRS) also ameliorated growth inhibition, presumably by competitively preventing tRNA1 Gln misacylation. However, when amounts of up to 10 mM L-glutamine, the cognate amino acid for acylation of tRNA1 Gln, were added to the growth medium, cell growth was unaffected. Overexpression of the B. subtilis gatCAB gene encoding GlutRNAGln amidotransferase (Glu-AdT) rescued cells from toxic effects caused by the formation of the mischarging GluRS. This result indicates that B. subtilis Glu-AdT recognizes the mischarged E. coli GlutRNA 1 Gln, and converts it to the cognate Gln-tRNA1 Gln species. B. subtilis GluRS-dependent Glu-tRNA1 Gln formation may cause growth inhibition in the transformed E. coli strain, possibly due to abnormal protein synthesis.
Park, Hee Kyung,Na, Duk L.,Han, Seol-Heui,Kim, Ji-Young,Cheong, Hae-Kwan,Kim, Seong Yoon,Kim, Sang Yun,Hong, Chang Hyung,Kim, Do-Kwan,Ku, Bon D.,Moon, So Young,Lee, Jun-Young,Shim, Yong S.,Youn, Young The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.9
<P>With rapid population aging, the socioeconomic burden caused by dementia care is snowballing. Although a few community-based studies of Alzheimer's disease (AD) have been performed in Korea, there has never been a nationwide hospital-based study thereof. We aimed to identify the demographics and clinical characteristics of mild-to-moderate AD patients from the Clinical Research Center for Dementia of Korea (CREDOS) registry. A total of 1,786 patients were consecutively included from September 2005 to June 2010. Each patient underwent comprehensive neurological examination, interview for caregivers, laboratory investigations, neuropsychological tests, and brain MRI. The mean age was 74.0 yr and the female percentage 67.0%. The mean period of education was 7.1 yr and the frequency of early-onset AD (< 65 yr old) was 18.8%. Among the vascular risk factors, hypertension (48.9%) and diabetes mellitus (22.3%) were the most frequent. The mean score of the Korean version of Mini-Mental State Examination (K-MMSE) was 19.2 and the mean sum of box scores of Clinical Dementia Rating (CDR-SB) 5.1. Based on the well-structured, nationwide, and hospital-based registry, this study provides the unique clinical characteristics of AD and emphasizes the importance of vascular factors in AD in Korea.</P>
지세인(S. I. Ji),이경훈(K. H. Lee),홍리석(L. S. Hong),정진영(J. Y. Jung),김종성(J. S. Kim),김병민(B. M. Kim) 한국소성가공학회 2014 한국소성가공학회 학술대회 논문집 Vol.2014 No.10
It was investigated that plenty of the processes of shape wire drawing process designed by trial and error relying on experience of industrial experts. In consequence of this process, it is inevitable that the increase of product cost, unnecessary time consuming, and effort. In case of manufacturing the final product with asymmetric section geometry and high aspect ratio, the concentration of strain at a side caused the severe distortion of the wire and low-cycle fatigue resistance is formed. The objective of this study is to design process of multi-pass shape wire drawing from initial round material with consideration of the cross section geometry of the final product. First, the multi-pass shape wire drawing process was designed by equivalent potential line in electric field analysis. The reduction ratio of area was calculated by relationship to the number of pass in multi pass shape wire drawing process determined by capacity of drawing machine and drawing force. In order to take account of concentration of strain of cross section of wire, the process for multi shape wire drawing from initial round material to an intermediate die was redesigned using electric field analysis again. In this study, the either drawing process design was estimated by finite element simulation in which the strain distribution and standard deviation plastic strain of the cross section of drawn wire.
Sohn, William S.,Lee, Tae Young,Yoo, Kwangsun,Kim, Minah,Yun, Je-Yeon,Hur, Ji-Won,Yoon, Youngwoo Bryan,Seo, Sang Won,Na, Duk L.,Jeong, Yong,Kwon, Jun Soo Frontiers Media S.A. 2017 Frontiers in neuroscience Vol.11 No.-
<P>Brain function is often characterized by the connections and interactions between highly interconnected brain regions. Pathological disruptions in these networks often result in brain dysfunction, which manifests as brain disease. Typical analysis investigates disruptions in network connectivity based correlations between large brain regions. To obtain a more detailed description of disruptions in network connectivity, we propose a new method where functional nodes are identified in each region based on their maximum connectivity to another brain region in a given network. Since this method provides a unique approach to identifying functionally relevant nodes in a given network, we can provide a more detailed map of brain connectivity and determine new measures of network connectivity. We applied this method to resting state fMRI of Alzheimer's disease patients to validate our method and found decreased connectivity within the default mode network. In addition, new measure of network connectivity revealed a more detailed description of how the network connections deteriorate with disease progression. This suggests that analysis using key relative network hub regions based on regional correlation can be used to detect detailed changes in resting state network connectivity.</P>
Kim, J L,Lee, J I,Ji, Y H,Kim, B H,Kim, J S,Chang, S Y Nuclear Technology Pub 2006 Radiation Protection Dosimeetry Vol.119 No.1
<P>The energy responses for the KLT-300(LiF:Mg,Cu,Na,Si, Korea), GR-200(LiF:Mg,Cu,P, China) and MCP-N(LiF:Mg,Cu,P, Poland) thermoluminescence(TL) pellets were studied for a photon radiation with energies from 1.25 MeV((60)Co) to 21 MV (Microtron) to verify the usefulness of the calibration for the radiotherapy beams. The International Atomic Energy Agency (IAEA) and the World Health Organization (WHO) have performed thermoluminescence dosimetry (TLD) audits to verify the calibration of the beams by TL powder, but TL pellets were used in this study because the element correction factor (ECF), defined as the factor to correct the variations that all TL dosemeters cannot be manufactured to have exactly the same TL efficiency, for each TL pellet could be accurately derived and be handled conveniently when compared with the powder. Also several works for the energy response of the TLDs were done for the low-energy photon beams up to (60)Co, but they will be extended in this experiment to the high photon energies (up to 20 MV), which are widely used in the therapy level of a radiation. The PTW 30006 ionisation chamber was calibrated by the Korea primary standards to establish the air-kerma rates and the TL pellets were irradiated in a specially designed waterproof pellet holder in a water phantom (30 x 30 x 30 cm(3)) just like the IAEA postal audits programme. This result was compared with that of another type of phantom [10 (W) x 10 (L) x 10 (H) cm(3) PMMA Perspex phantom for the (60)Co and 6 MV photon, and 10 x 10 x 20 (H) cm(3) for the 10 and 21 MV photon] for its convenient use and easy handling and installation in a hospital. The results show that the differences of the responses for the water phantom and PMMA Perspex phantom were negligible, which is contrary to the general conception that a big difference would be expected. For an application of these results to verify the therapy beams, an appropriate energy correction factor should be applied to the energies and phantom types in use.</P>
Tl2Ba2CaCu2O8 Thin Films on MgO and Sapphire Substrates
X.J. Zhao,S.L. Yan,C. Zhang,E. Chen,L. Fang,L. Ji,Q.L. Xie,S. Li,T.G. Zhou,X. Zhang,X. Zuo,Y.G. Li 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
High quality Tl2Ba2CaCu2O8(Tl-2212) films were grown on MgO and sapphire substrates with CeO2 buffer layers. The CeO2 buffer layers were prepared by using an in-situ process with RF magnetron sputtering. The Tl-2212 thin films were then fabricated in a two-step process: deposition of the Tl-containing precursor film and low-temperature post-thallination of the precursor film. The resulting Tl-2212 films showed an excellent biaxial texture. The superconducting transition temperatures, Tc’s, of the films on MgO and sapphire were 103.4 and 104.2 K, respectively. The critical current densities Jc at 77 K and zero magnetic field were as high as 2.37 × 106 A/cm2 for the film on MgO and 1.76 × 106 A/cm2 on sapphire. A surface resistance of 725 μ at 10 GHz and 77 K was obtained in the Tl-2212 film on CeO2 buffered sapphire.
LAMC2 enhances the metastatic potential of lung adenocarcinoma
Moon, Y W,Rao, G,Kim, J J,Shim, H-S,Park, K-S,An, S S,Kim, B,Steeg, P S,Sarfaraz, S,Changwoo Lee, L,Voeller, Donna,Choi, E Y,Luo, Ji,Palmieri, D,Chung, H C,Kim, J-H,Wang, Y,Giaccone, G Macmillan Publishers Limited 2015 Cell death and differentiation Vol.22 No.8
Lung cancer is the number one cancer killer, and metastasis is the main cause of high mortality in lung cancer patients. However, mechanisms underlying the development of lung cancer metastasis remain unknown. Using genome-wide transcriptional analysis in an experimental metastasis model, we identified laminin γ2 (LAMC2), an epithelial basement membrane protein, to be significantly upregulated in lung adenocarcinoma metastatic cells. Elevated LAMC2 increased traction force, migration, and invasion of lung adenocarcinoma cells accompanied by the induction of epithelial–mesenchymal transition (EMT). LAMC2 knockdown decreased traction force, migration, and invasion accompanied by EMT reduction in vitro, and attenuated metastasis in mice. LAMC2 promoted migration and invasion via EMT that was integrin β1- and ZEB1-dependent. High LAMC2 was significantly correlated with the mesenchymal marker vimentin expression in lung adenocarcinomas, and with higher risk of recurrence or death in patients with lung adenocarcinoma. We suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT and may be a potential therapeutic target.
Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils
Ji, S.,Hyun, J.,Park, E.,Lee, B.-L.,Kim, K.-K.,Choi, Y. Munksgaard 2007 Journal of periodontal research Vol.42 No.5
<P>Background and Objective: </P><P>The aim of this study was to compare the susceptibility of nonperiodontopathic and periodontopathic bacteria to major defense mechanisms for bacterial clearance in gingival sulcus.</P><P>Material and Methods: </P><P>Twenty strains of 13 oral bacterial species were studied for their susceptibility to phagocytosis by human neutrophils and to the antimicrobial peptides LL-37 and human beta defensin-3. The minimum inhibitory concentrations of LL-37 and human beta defensin-3 were determined by a liquid dilution assay, and susceptibility to phagocytosis was examined by a flow cytometric phagocytosis assay.</P><P>Results: </P><P>The minimum inhibitory concentrations of LL-37 and human beta defensin-3 varied greatly, depending on the strain and species. Although a significant difference between the non- and periodontopathic groups was not observed, the red-complex bacteria were more resistant to LL-37 than the others (<I>p =</I> 0.004). The susceptibility of oral bacteria to phagocytosis was quite variable, depending on the species but not on the strains<I>.</I> The periodontopathic bacteria, especially <I>Actinobacillus actinomycetemcomitans</I> and the red-complex triad, were more resistant to phagocytosis than were the nonperiodontopathic bacteria (<I>p</I> = 0.0003). In addition, bacteria resistant both to antimicrobial peptides and to phagocytosis were more common in the periodontopathic group.</P><P>Conclusion: </P><P>Our results indicate that immune evasion may contribute to the pathogenicity of some periodontopathic bacteria.</P>