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- 저자 : Ruilian Li (검색결과 2 건)
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Ruilian Xiu,Jie Jia,Qing Zhang,Fengjiao Liu,Yaxin Jia,Yuanyuan Zhang,Beibei Song,Xiaodan Liu,Jingwei Chen,Dongyang Huang,Fan Zhang,Juanjuan Ma,Honglin Li,Xuan Zhang,Yunyun Geng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6
Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration- dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 μM, 19.7 ± 0.4 μM, and 24.5 ± 2.1 μM, while the maximal effect (Emax) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.
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Investigation of the interstitial oxygen behaviors in vanadium alloy: A first-principles study
Xingming Zhang,Yifan Li,Qiaoling He,Ruilian Li,Lei Deng,Liang Wang,Xunlin Liu,Jianfeng Tang,Huiqiu Deng,Wang-Yu Hu 한국물리학회 2018 Current Applied Physics Vol.18 No.2
This study aims at characterizing the interstitial Oxygen (O) behaviors in the Vanadium (V) Alloy by means of the first-principles calculations. For this, the interations between vacancy (Vac) and O interstitil atom are studied in detail to obtain the binding energies and stable structures of the complexes. It can be seen that monovacancy binding with two O atoms occupied the opposing octahedral stie are particularly stable, and is liable to form VacO2 cluster in the V alloys. According to the mass action analysis, the predicted temperature dependence of the concentration for VacOn complexes are presented. Apart from monovacancy, we also consider the trapping behavior of vacancy cluster on the O atoms. The results also prove that one vacancy can trap two O atoms in the V alloys. Based the diffusion theory, we obtain the diffusion coefficients as a function of temperature with or without the vacancy effect in the V alloys. The predicted O diffusion coefficients in defect-free V alloys from our first-principles calculations are in excellent ageement with the experimental data, meanings that the vacancy-limited mechanism does not play the key role for O diffusion in V alloys. Regarding the interactions between vacancy, solutes and O atom, combining with the diffusion barriers of O affected by vacancy and solute, we infer the formation mechanism of the precipitates in the V alloys.
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