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Jin-Rui Wei,Kun Liu,Faquan Lin,Chunping He,Xuan Luo,Jiajia Zou,Wei He,Wenqian Nong,Cui-Wu Lin 한국응용생명화학회 2016 Applied Biological Chemistry (Appl Biol Chem) Vol.59 No.2
Four hydroxybenzamide derivatives were synthesized from protocatechuic acid. The antioxidant activities of these derivatives were evaluated in vitro using DPPH radical scavenging and reducing power assays. In addition, these compounds were subjected to a chromogenic thrombin-inhibitory assay using Chromozym-TH as the substrate. The anticancer effects of these derivatives were also investigated using the MTT assay in three human cancer cell lines. Four derivatives exhibited excellent DPPH radical scavenging activity and redox potential. Their highly inhibitory effect against thrombin may allow them to be utilized as novel micromolecule thrombin inhibitors. Furthermore, four derivatives demonstrated different inhibitory activities in three human cancer cell lines but showed minimal harmful effects on normal HUVEC cells. Therefore, hydroxybenzamide derivatives indicate the superior antioxidant, thrombin-inhibitory, and anticancer activities along with the excellent biocompatibility, which have the potential application in therapeutic interventions and disease prevention of cancer, thrombotic diseases, and aging.
Antioxidant Activity of Water Extract from the Cultured Mycelia of Phellinus Baumii
Jin Won Hyun,Jinny Park,Kyoung Ah Kang,Rui Zhang,Mei Jing Piao,Soyoon Park,Jin Seo Park,Young Kook Kim,Mun Chaul Rho,Hyun Sun Lee 대한암예방학회 2006 Journal of cancer prevention Vol.11 No.4
The antioxidant property of cultured mycelia of Phellinus baumii was investigated. The water-soluble extract isolated from these mycelia showed intracellular reactive oxygen species, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and lipid peroxidation inhibitory activities. This radical scavenging activity of extract protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to H2O2. Furthermore, water extract reduced the apoptotic cells induced by H2O2, as demonstrated by the decreased number of sub G1 hypo-diploid cells and apoptotic body formation and it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that mycelia of P. baumii exhibit antioxidant property. (Cancer Prev Res 11, 329-335, 2006)
The Investigation on Thermal Aging Characteristics of Oil-Paper Insulation in Bushing
Rui-jin Liao,En-de Hu,Li-jun Yang,Zuo-ming Xu 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
Bushing is the key link to connect outer and inner insulating systems and also the essential electric accessory in electric power system, especially in the high voltage engineering (AC 1000kV, DC 800kV). This paper presented the experimental research of thermal aging characteristic of oilpaper insulation used in bushing. A thermally accelerated aging experiment at 90℃ was performed. The bushing models containing five layers of paper were sealed into the aging vessels and further aged for 250 days. Then several important parameters associated with the aging were observed and evaluated. The results showed that the degree of polymerization (DP) of papers gradually decreased. The DP values of outermost layer and middle layer fit well into the second-order kinematic model and first-order kinematic model, respectively. Less deterioration speed of the inter-layer paper than outer layer was confirmed by the variation of DP. Hydrolysis was considered as the main cause to this phenomenon. In addition, the logarithm of the furfural concentrations in insulation oil was found to have good linear relationship with DP of papers. Interestingly, when the aging time is about 250 days and DP is 419, the aging process reaches an inflection point at which the DP approaches the leveling off degree of polymerization (LODP) value. Both tanδ and acid number of oils increased, while surface and volume resistivity of papers decreased. The obtained results demonstrated that thermal aging and moisture absorbed in papers brought great influence to the degradation of insulating paper, leading to rapid decrease of DP and increase of the tanδ . Thus, the bushing should be avoided from damp and real-time monitoring to the variation of tanδ and DP values of paper is an effective way to evaluate the insulation status of bushing.
Preventive Effect of 7,8-Dihydroxyflavone against Oxidative Stress Induced Genotoxicity
Zhang, Rui,Kang, Kyoung Ah,Piao, Mei Jing,Ko, Dong Ok,Wang, Zhi Hong,Chang, Weon Young,You, Ho Jin,Lee, In Kyung,Kim, Bum Joon,Kang, Sam Sik,Hyun, Jin Won Pharmaceutical Society of Japan 2009 Biological & pharmaceutical bulletin Vol.32 No.2
<P>We elucidated the protective effect of 7,8-dihydroxyflavone against hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>)-induced DNA damage. We found that 7,8-dihydroxyflavone scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). 7,8-Dihydroxyflavone with antioxidant effect prevented the H<SUB>2</SUB>O<SUB>2</SUB>-induced cellular DNA damage, as evidenced by comet tail, 8-hydroxy-2′-deoxyguanosine (8-OHdG) content, and phospho-histone H2A.X protein expression. Hence, 7,8-dihydroxyflavone was shown to protect cell <I>via</I> the inhibition of apoptosis induced by H<SUB>2</SUB>O<SUB>2</SUB>. This was substantiated by decreased apoptotic nuclear fragmentation, decreased sub-G<SUB>1</SUB> cell population, and decreased DNA fragmentation. Furthermore, 7,8-dihydroxyflavone activated the protein kinase B (PKB, Akt) signal pathway, which is a major survival signal pathway. In addition, LY294002, which is phosphatidylinositol 3 kinase (PI3K, upstream of Akt) inhibitor, attenuated the protective effect of 7,8-dihydroxyflavone against H<SUB>2</SUB>O<SUB>2</SUB>-induced cell damage. In conclusion, 7,8-dihydroxyflavone was shown to possess cytoprotective properties against oxidative stress by scavenging intracellular ROS and enhancing Akt activity.</P>
Ding, Jin-Rui,Kim, Kyo-Seon American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.2
<P>Tungsten oxide thin films have been found as an active visible light driven photoanode material for photoelectrochemical water splitting due to its good stability in aqueous solution and energetically favorable valence band position for water oxidation. Morphology control, which determines the performance of WO3 photoanode, is one of most focuses of recent research interests. In this work, we successfully prepared monoclinic WO3 thin films on ITO glass at low range of substrate temperature with a fabrication rate around 100 nm per minute by using aerosol flame deposition process. Single crystal nanocolumns with both triangular pyramid-like and triangular prism-like structure were obtained at certain process conditions. Photoelectrochemical properties of photoelectrodes assembled with both structured WO3 thin films were investigated. The prism-like nanocolumn-structured thin film generated the current density of 1.58 mAcm(-2) at potential of 1.0 V versus Ag/AgCl in 0.5 M H2SO4 solution under illumination of AM 1.5 simulated solar light (100 mVcm(-2)). It presented superior photoelectrochemical performance to pyramid-like nanocolumn-structured WO3 thin film.</P>