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- 저자 : Rong Yuan (검색결과 137 건)
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Yuan, Yuan,Cai, Hui,Yang, Xiao-Jun,Li, Wei,He, Jin,Guo, Tian-Kang,Chen, Yi-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: The aim of this study was to investigate the effect of a c-myc antisense oligodeoxynucleotide and 5-fluorouracil on the expression of c-myc, invasion and proliferation of HEPG-2 liver cancer cells. Materials and Methods: HEPG-2 cells were treated with lipiosome-mediated c-myc ADSON and 5-fluorouracil. The proliferation inhibition rate and invasion were measured by MTT and invasion assay, respectively. Cell apoptosis was detected by flow cytometry and expression of c-myc by RT-PCR and immunohistochemistry. Results: The proliferation inhibition rate was significantly higher in the antisense oligodeoxynucleotide added-5-fluorouracil group than single antisense oligodeoxynucleotide or 5-fluorouracil group (p<0.05). G0/G1 cells in the antisense oligodeoxynucleotide group and S cells in the 5-fluorouracil groups were significantly increased than that in the control group, respectively (P<0.01). The amplification strips of PCR products in 5-FU, ASODN and combination groups were significantly weaker than that in the control group (P<0.01). The percentage of c-myc-protein-positive cells were significantly lower in antisense oligodeoxynucleotide, 5-fluorouracil and combination groups than that in the control group (P<0.01). Conclusions: A liposome-mediated c-myc antisense oligodeoxynucleotide and 5-fluorouracil can inhibit the proliferation and invasion of liver cancer cells by reducing the expression of c-myc. A c-myc antisense oligodeoxynucleotide can increase the sensitivity of liver cancer cells to 5-fluorouracil and decrease the dosage of the agent necessary for efficacy, providing an experimental basis for the clinical therapy of liver cancer.
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Yuan, Ping-Rong,Kim, Hyun-Jung,Chen, Qiong-Hua,Ju, Hong-Guang,Ji, Shi-Dong,Ahn, Sang-Nag 한국작물학회 2010 Journal of crop science and biotechnology Vol.13 No.4
Quantitative trait loci (QTL) associated with four milling recovery properties, two chemical properties, six paste properties of grain, and six textural parameters of cooked rice were identified using an introgression line (IL) population of rice developed from an interspecific cross over two years. The IL population consisted of 121 lines from a cross between wild rice (O. rufipogon Griff.) and a japonica cultivar. A total of 28 QTLs were identified for the 14 traits using inter mapping. Of these, 10 were significant over two years indicating that these QTLs are stable across years and environments. For eight (21 %) of the QTLs identified, the O. rufipogon-derived alleles contributed a desirable effect on amylose content, protein content, minimum viscosity, final viscosity, and consistency. Among these, pc3 for protein content and ac7 for amylose content were significant in both years and showed an $R^2$ value of 25.5 and 30.9%, respectively. The markers closely associated with these useful alleles can be used to trace the inheritance of specific chromosome segments in the IL population and also offer a starting point for map-based cloning of genes underlying these traits.
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Rong-Yuan Qin,임병진 한국무역연구원 2015 무역연구 Vol.11 No.3
This paper is concerned with the hedging effectiveness of CSI 300 stock-index futures in the China spot market. Various models are used to estimate hedge ratio, namely simple ordinary least squares(OLS), vector error correction model(VECM) and a class of multivariate generalized autoregressive conditional heteroscedastic model (GARCH). The multivariate GARCH model can estimate the time varying hedge ratio whereas the other models give a constant hedge ratio. The data consists of CSI 300 index and its stock-index futures covering the period April 16, 2010 to January 18, 2013 with 669 observations. The hedge performance analysis was performed by out-of-sample. The hedging performance of the models may vary according to the hedge horizon. Therefore, this paper considered the hedging effectiveness of the three models described previously over daily, weekly and monthly horizons. In order to analyze the hedge performance using out-of-sample, the total sample was split into two sections. The first 601 observations were used to estimate the optimal hedge ratio providing 600 returns for each variable and the remaining 68 observations were utilized to check the efficiency of the estimated hedge ratio.Based on analysis of this study, the following conclusions have been drawn: First, the stationarity of the data series were checked using the Augmented Dickey Fuller (ADF) and Phillips and Perron (PP) tests. These results showed that the time series of variable level contain unit roots and were non-stationary, while the time series of first difference variables were stationary at 1% level. Second, the Johansen Co-integration model was applied to find out the co-integration between CSI 300 index and its stock-index futures. The results showed that the null hypothesis of no co-integration between test variables was rejected. Hence, it can be depicted that the variables exhibit a long-run association between each other. Third, the out-of-the-sample forecasts concluded that the VECM and GARCH (1, 1) models resulted to about the same performance of hedging effectiveness with higher percentage in variance reduction than OLS model. The CSI 300 stock-index futures contracts provide a reasonably high level of hedging effectiveness (i.e. 80%~96%) and it can be said that CSI 300 futures contracts provided useful risk management tool hedging and for portfolio diversification.
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Yuan, Ping-Rong,Kim, Hyun-Jung,Chen, Qiong-Hua,Ju, Hong-Guang,Lee, Seung-Joon,Ji, Shi-Dong,Ahn, Sang-Nag 한국작물학회 2009 Journal of crop science and biotechnology Vol.12 No.4
The nearly isogenic nature of the introgression lines (ILs) provides a relative advantage over other segregating populations in the rapid implementation of pyramiding approach through crosses and marker analysis. A set of 126 ILs carrying various introgressed segments from a presumed wild progenitor, Oryza rufipogon Griff. Acc. W1944 in the background of an elite Korea japonica cultivar (O. sativa L.), Hwayeongbyeo, was constructed using the marker assisted selection (MAS) technique combined with repeated backcrosses. The 126 ILs have different W1944 segments on each chromosome, with 100% coverage of wild segments on chromosome 1, while for chromosome 10, the coverage was only 33.3%. The mean number of homozygous and heterozygous donor segments were 3 (ranging from 0 to 7) and 4.7 (ranging from 1 to 14.5), respectively, and 31.6% of introgressed segments had sizes of less than 10.5 cM. A total of 41 quantitative trait loci (QTLs) and two loci associated with pericarp coloration were identified. The number of QTLs per trait ranged from 2 to 6. Phenotypic variance associated with each QTL varied from 9.1 to 52.2%, with an average of 17.1%. For 11 (26.8%) of the QTLs detected in this study, the O. rufipogon-derived alleles contributed the desired agronomic effect despite the overall inferior characteristics of the wild phenotype. Favorable alleles from the O. rufipogon accession were identified for panicle number, panicle length, days to heading, secondary branches, spikelets per panicle, and 1,000-grain weight.
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The Lead-Lag Relationship between Volatility Index Futures and Spot in the Korean Stock Market
Rong-Yuan Qin,Ji-Hun Heo 한국무역연구원 2017 무역연구 Vol.13 No.4
This empirical study examines the short-run lead-lag relationship between the VKOSPI index futures and its underlying spot index and KOSPI index using daily data from September 17, 2014 to May 2017. We used the unit root test, Johansen-Juselius cointegration test, Granger causality analysis, impulse response function analysis, and variance decomposition analysis to test the hypothesis that the futures market with no market frictions leads the spot market in this analysis. The results of these analyses using level variables show that there is a bi-directional lead-lag relationship between the VKOSPI futures and VKOSPI index, but in the analysis using first-difference variables, there is only a unidirectional lead-lag relationship form VKOSPI index to VKOSPI futures. This means that the VKOSPI spot market is more efficient than the futures market. Also, there are no lead-lag relationship from VKOSPI futures or VKOSPI index to KOSPI index. It is inconsistent with the main expected hypothesis in our study and the conclusions of previous studies which argue that the VIX futures lead the VIX index and S&P 500 index. This results are related to a lack of liquidity of VKOSPI futures contracts in the Korean derivatives market. Because generally, the Korean institutional investors prefer option trading, to hedge market risk rather than VKOSPI futures. Change in the price of the option will result in the change in the VKOSPI index and subsequently the mechanism that alters the VKOSPI futures or the KOSPI index.
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Rong-Yuan Qin,Ji-Hun Heo 한국무역연구원 2017 무역연구 Vol.13 No.1
This empirical study examines the short-term dynamic lead-lag relationship between five-year Chinese government bond futures index and its underlying spot index, using daily data from September 06, 2013 to August 31, 2016. We carry out unit root test, Johansen-Juselius cointegration test, Granger causality analysis, impulse response function analysis, and variance decomposition analysis. The empirical results of this paper reveal that five-year Chinese government bond futures and spot level variables are non-stationary time series data with unit root, but the first differences in the logarithm of the prices are stationary. As a result of the cointegration test, it was confirmed that there is no long-term equilibrium relationship between the two level variables (price). Lastly, the results of Granger causality, impulse response functions, and the variance decomposition analysis show that the returns of five-year Chinese government bond futures one-sidedly lead the underlying spot returns. This means that the five-year government bond futures market is more efficient in China. Also, these results are consistent with the results of previous studies, and are expected to be useful for traders, regulatory bodies and practitioners for several reasons, such as price discovery, hedging and arbitrage opportunities.
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Ping-Rong Yuan,Hyun-Jung Kim,Qiong-Hua Chen,Hong-Guang Ju,Seung-Joon Lee,Shi-Dong Ji,안상낙 한국작물학회 2009 Journal of crop science and biotechnology Vol.12 No.4
The nearly isogenic nature of the introgression lines (ILs) provides a relative advantage over other segregating populations in therapid implementation of pyramiding approach through crosses and marker analysis. A set of 126 ILs carrying various introgressedsegments from a presumed wild progenitor, Oryza rufipogon Griff. Acc. W1944 in the background of an elite Korea japonica cultivar(O. sativa L.), Hwayeongbyeo, was constructed using the marker assisted selection (MAS) technique combined with repeatedbackcrosses. The 126 ILs have different W1944 segments on each chromosome, with 100% coverage of wild segments on chromosome1, while for chromosome 10, the coverage was only 33.3%. The mean number of homozygous and heterozygous donor segmentswere 3 (ranging from 0 to 7) and 4.7 (ranging from 1 to 14.5), respectively, and 31.6% of introgressed segments had sizes ofless than 10.5 cM. A total of 41 quantitative trait loci (QTLs) and two loci associated with pericarp coloration were identified. Thenumber of QTLs per trait ranged from 2 to 6. Phenotypic variance associated with each QTL varied from 9.1 to 52.2%, with an averageof 17.1%. For 11 (26.8%) of the QTLs detected in this study, the O. rufipogon-derived alleles contributed the desired agronomiceffect despite the overall inferior characteristics of the wild phenotype. Favorable alleles from the O. rufipogon accession were identifiedfor panicle number, panicle length, days to heading, secondary branches, spikelets per panicle, and 1,000-grain weight.
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