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Rhyou Hyo-In,남영희,박해심 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.2
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is a unique condition characterized by aspirin/NSAID hypersensitivity, adult-onset asthma, and/or chronic rhinosinusitis with nasal polyps. Arachidonic acid metabolism dysregulation and intense eosinophilic/type 2 inflammation are central mechanisms in NERD. Studies have been conducted on various biomarkers, and urinary leukotriene E4 is considered the most available biomarker of NERD. However, the pathophysiology of NERD is heterogeneous and complex. Epithelial cells and platelets can interact with immune cells in NERD, and novel biomarkers related to these interactions have recently been investigated. We summarize emerging novel biomarkers of NERD and discuss their roles in the management of NERD.
류경선(Rhyou, Kyoung Sun),양영희(Yang, Young Hee) 노인간호학회 2018 노인간호학회지 Vol.20 No.1
Purpose: This study was done to investigate characteristics and clinical outcomes in older adults with aspiration pneumonia and to identify differences in clinical outcomes according to the general and clinical characteristics of the elders. Methods: The 2011 to 2016 emergency medical center electronic records of 138 patients aged 65 years or older with aspiration pneumonia were reviewed. Results: The major characteristics of the participants were: 75 years of age or older (72.5%), male (63.8%), neurological or cardiovascular disease (58.7%), two or more chronic diseases (71.7%), dependent walking (79.7%) and dependent eating (79.0%). In the treatment outcomes, 42% of the participants got worse or died. The hospital length of stay varied according to causes of aspiration (x2=13.35, p=.004), neoplastic disease (Z=-2.24, p=.025), and paralysis (Z=-3.08 p=.002). There were differences in intensive care unit admissions according to the number of chronic diseases (x2=6.00, p=.041) and pneumonia severity index classification (x2=17.64, p<.001). The place of residence (x2=6.85, p=.033), serum albumin (x2=6.26, p=.044), and pneumonia severity index classification (x2=10.99, p=.001) influenced the treatment outcomes. Conclusion: Older patients with the characteristics presented in this study would be classified as the aspiration pneumonia risk group and should be provided with preventive interventions.