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프레팔시드 정(시사프리드 5 mg)에 대한 시사플 정의 생물학적 동등성
이계주,황성주,우종수,곽손혁,박종우,한정희,장혁,남진경,구선회 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.1
Bioequivalence of two cisapride tablets, test drug (Cisaple^ⓡ tablet: Hanmi Pharm Co., Ltd.) and reference drug (Prepulsid^ⓡ tablet: Janssen Pharm. Co., Ltd.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty two healthy male volunteers were divided randomly into two groups and administered the drug orally at the dose of 10 mg as cisapride in a 2 × 2 crossover study. There was a week washout period between administrations. Blood samples were taken at predetermined time intervals for 36 hr and the plasma concentration of cisapride was determined by a HPLC method. AUC_(0-36hr) (area under the plasma concentration-time curve from time zero to 36 hr), C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were estimated from the plasma drug concentrationtime data. Analysis of variance (ANOVA) revealed no difference in AUC-(0-36hr), C_(max) and T_(max) between two products. The apparent differences of these parameters between two products were less than 20% (i.e., 5.38, 6.17 and 0.00% for AUC_(0-36hr), C_(max) and T_(max), respectively). The powers (1-β) for AUC_(0-36hr), C_(max) and T_(max) were over 0.9. Minimal detectable differences (△) at α=0.05, 1-β=0.8 were less than 20% (i.e. 17.67, 14.84 and 19.72% for AUC_(0-36hr), C_(max) and T_(max), respectively). The 90% confidence intervals (δ) for these parameters were also within ±20% (i.e. -4.97 ≤ δ ≤ 15.73, -2.53 ≤ δ ≤ 14.86 and -11.55 ≤ δ ≤ 11.55 for AUC_(0-36hr), C_(max) and T_(max), respectively). These results satisfied the criteria of KFDA guidelines for bioequivalence, indicating the two tablets of cisapride were bioequivalent.
전남지방에 수입된 Aberden Angus종 및 Hereford종 육용우의 질병발생상황
위성하,김승중,이성회,박래생,Wee Sung Ha,Kim Seung Joong,Rhee Sung Hoe,Park Lae Seng 대한수의사회 1980 대한수의사회지 Vol.16 No.11·12
An annual incidence of disease and mortality rate was surveyed to the 573 imported beef cattle in sunchun district, Jeonnam during 1979 inorder to evaluate to advanced animal health control and laboratory reutine examinations for piroplasmosis and interna
( Lam Hoang ),( Kyung Sik Song ),( In Koo Rhee ),( Jeong Hoe Kim ),( Sang Man Lee ) 한국식물학회 2007 Journal of Plant Biology Vol.50 No.4
To analyze the growth inhibitory mechanism of a 2-aminobenzoic acid (2-AA) derived from Bacillus cereus EJ-121, we treated Arabidopsis thaliana plants with 2-AA, 2-AA analogs, auxin (NAA), a known auxin transport inhibitor [2,3,5-triiodobenzoic acid (TIBA)], and an ethylene action inhibitor [silver thiosulfate (Ag)]. Root development was significantly inhibited by 50 Μm 2-AA, whereas the growth of bacteria and yeast was undeterred. The application of two 2-AA analogs - 3-aminobenzoic acid (3-AA) and 4-aminobenzoic acid (4-AA) - did not impair Arabidopsis root growth at concentrations below 100 μM. These results suggest that the effect of 2-AA is not due to its chemical structure, but because of its conversion to another metabolite, IAA. To confirm this, we supplemented TIBA in the growth medium, and found that the degree of inhibition was significantly reduced. Similarly, when plants were co-treated with 100 μM Ag, the negative effect of 50 μM 2-AA was greatly diminished. All of these observations support the proposal that this inhibition results from the conversion of 2-AA to IAA. Furthermore, the increased auxin level leads to a rise in ethylene synthesis, which then blocks root growth and, ultimately, retards overall plant development.