Multi-Level modeling and access control for data sharing in collaborative design

Kim, Taeseong,Cera, Christopher D.,Regli, William C.,Choo, Hyunseung,Han, JungHyun Elsevier 2006 ADVANCED ENGINEERING INFORMATICS Vol.20 No.1

<P><B>Abstract</B></P><P>This paper presents a method for securing collaborative design using multi-level modeling. When a team of designers works collaboratively on a 3D assembly model, a component of the assembly is presented in a full detail to those who have full access privileges to the component, but in an abstract level of detail to those who have less access privileges. Such various levels of detail can be created in two phases: volumetric feature removal which is achieved through interactive feature recognition on the CAD model, and multi-resolution mesh construction which is based on polygonal simplification. Appropriate representations of the assembly are extracted by direction of access matrix, and then presented to the users participating in collaborative design. The key issues in developing the secure collaborative design system are discussed, and the implementation results are reported.</P>

TomoRay: Generating Synthetic Computed Tomography of the Spine From Biplanar Radiographs

Olivier Zanier,Sven Theiler,Raffaele Da Mutten,유승준,Luca Regli,Carlo Serra,Victor E. Staartjes 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: Computed tomography (CT) imaging is a cornerstone in the assessment of patients with spinal trauma and in the planning of spinal interventions. However, CT studies are associated with logistical problems, acquisition costs, and radiation exposure. In this proof-of-concept study, the feasibility of generating synthetic spinal CT images using biplanar radiographs was explored. This could expand the potential applications of x-ray machines pre-, post-, and even intraoperatively. Methods: A cohort of 209 patients who underwent spinal CT imaging from the VerSe2020 dataset was used to train the algorithm. The model was subsequently evaluated using an internal and external validation set containing 55 from the VerSe2020 dataset and a subset of 56 images from the CTSpine1K dataset, respectively. Digitally reconstructed radiographs served as input for training and evaluation of the 2-dimensional (2D)-to-3-dimentional (3D) generative adversarial model. Model performance was assessed using peak signal to noise ratio (PSNR), structural similarity index (SSIM), and cosine similarity (CS). Results: At external validation, the developed model achieved a PSNR of 21.139 ± 1.018 dB (mean ± standard deviation). The SSIM and CS amounted to 0.947 ± 0.010 and 0.671 ± 0.691, respectively. Conclusion: Generating an artificial 3D output from 2D imaging is challenging, especially for spinal imaging, where x-rays are known to deliver insufficient information frequently. Although the synthetic CT scans derived from our model do not perfectly match their ground truth CT, our proof-of-concept study warrants further exploration of the potential of this technology.

Whole Spine Segmentation Using Object Detection and Semantic Segmentation

Raffaele Da Mutten,Olivier Zanier,Sven Theiler,유승준,Luca Regli,Carlo Serra,Victor E. Staartjes 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: Virtual and augmented reality have enjoyed increased attention in spine surgery. Preoperative planning, pedicle screw placement, and surgical training are among the most studied use cases. Identifying osseous structures is a key aspect of navigating a 3-dimensional virtual reconstruction. To automate the otherwise time-consuming process of labeling vertebrae on each slice individually, we propose a fully automated pipeline that automates segmentation on computed tomography (CT) and which can form the basis for further virtual or augmented reality application and radiomic analysis. Methods: Based on a large public dataset of annotated vertebral CT scans, we first trained a YOLOv8m (You-Only-Look-Once algorithm, Version 8 and size medium) to detect each vertebra individually. On the then cropped images, a 2D-U-Net was developed and externally validated on 2 different public datasets. Results: Two hundred fourteen CT scans (cervical, thoracic, or lumbar spine) were used for model training, and 40 scans were used for external validation. Vertebra recognition achieved a mAP50 (mean average precision with Jaccard threshold of 0.5) of over 0.84, and the segmentation algorithm attained a mean Dice score of 0.75 ± 0.14 at internal, 0.77 ± 0.12 and 0.82 ± 0.14 at external validation, respectively. Conclusion: We propose a 2-stage approach consisting of single vertebra labeling by an object detection algorithm followed by semantic segmentation. In our externally validated pilot study, we demonstrate robust performance for our object detection network in identifying individual vertebrae, as well as for our segmentation model in precisely delineating the bony structures.

Improving the Patient-Physician Relationship in the Digital Era - Transformation From Subjective Questionnaires Into Objective Real-Time and Patient-Specific Data Reporting Tools

Nicolai Maldaner,Atman Desai,Oliver P. Gautschi,Luca Regli 대한척추신경외과학회 2019 Neurospine Vol.16 No.4

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Lower Extremity Motor Deficits Are Underappreciated in Patient-Reported Outcome Measures: Added Value of Objective Outcome Measures

Martin Nikolaus Stienen,Nicolai Maldaner,Marketa Sosnova,Holger Joswig,Marco Vincenzo Corniola,Luca Regli,Gerhard Hildebrandt,Karl Schaller,Oliver Pascal Gautschi 대한척추신경외과학회 2020 Neurospine Vol.17 No.1

Objective: The patient-reported outcome measure (PROM)-based evaluation in lumbar degenerative disc disease (DDD) is today’s gold standard but has limitations. We studied the impact of lower extremity motor deficits (LEMDs) on PROMs and a new objective outcome measure. Methods: We evaluated patients with lumbar DDD from a prospective 2-center database. LEMDs were graded according to the British Medical Research Council (BMRC; 5 [normal] –0 [no movement]). The PROM-based evaluation included pain (visual analogue scale), disability (Oswestry Disability Index [ODI] & Roland-Morris Disability Index [RMDI]), and health-related quality of life (HRQoL; Short-Form 12 physical component summary/mental component summary & EuroQol-5D index). Objective functional impairment (OFI) was determined as age- and sex-adjusted Timed-Up and Go (TUG) test value. Results: One hundred five of 375 patients (28.0%) had a LEMD. Patients with LEMD had slightly higher disability (ODI: 52.8 vs. 48.2, p=0.025; RMDI: 12.6 vs. 11.3, p=0.034) but similar pain and HRQoL scores. OFI T-scores were significantly higher in patients with LEMD (144.2 vs. 124.3, p=0.006). When comparing patients with high- (BMRC 0–2) vs. low-grade LEMD (BMRC 3–4), no difference was evident for the PROM-based evaluation (all p>0.05) but patients with high-grade LEMD had markedly higher OFI T-scores (280.9 vs. 136.0, p=0.001). Patients with LEMD had longer TUG test times and OFI T-scores than matched controls without LEMDs. Conclusion: Our data suggest that PROMs fail to sufficiently account for LEMD-associated disability, which is common and oftentimes bothersome to patients. The objective functional evaluation with the TUG test appears to be more sensitive to LEMD-associated disability. An objective functional evaluation of patients with LEMD appears reasonable.

카나다의 에너지현황과 한$\cdot$가 에너지협력 전망

Dorrett Reg. H. 한국원자력산업회의 1987 원자력산업 Vol.7 No.8

본고는 지난 6월 23일 미국원자력학회(ANS) 한국지부 월례회에서 ${\ulcorner}$Canadian Energy : Resources, Policies and Commercial Opportunities${\lrcorner}$라는 제목으로 행한 특별강연문을 번역한 것이다.

Pilot Symbol Aided Dual-Channel QPSK ( PSADC QPSK ) for CDMA Reverse Links

Seong Reg Kim,Sug Bong Kang,Jeong Goo Lee,Jeong Seok Ha 대한전자공학회 1997 CDMA International Conference and Exhibition Vol.- No.-

A rare TNNT1 gene variant causing creatine kinase elevation in nemaline myopathy: c.271_273del (p.Lys91del)

Yavaş Cüneyd,Doğan Mustafa,Eröz Recep,Türegün Kübra 한국유전학회 2024 Genes & Genomics Vol.46 No.5

Background Nemaline Myopathy (NM) is a rare genetic disorder that affects muscle function and is characterized by the presence of nemaline rods in muscle fibers. These rods are abnormal structures that interfere with muscle contraction and can cause muscle weakness, respiratory distress, and other complications. NM is caused by variants in several genes, including TNNT1, which encodes the protein troponin T1. NM is inherited in an autosomal recessive pattern. The prevalence of heterozygous TNNT1 variants has been reported to be 1/152,000, indicating that the disease is relatively rare. Objective Investigation of TNNT1 gene variants that may cause cretin kinase elevation. Methods Detailed family histories and clinical data were recorded. Whole exome sequencing was performed and family segregation was done by Sanger sequencing. Results In this study, we report a 5-year-old girl with a novel variant recessive congenital TNNT1 myopathy. The patient had a novel homozygous (c.271_273del) deletion in the TNNT1 gene that is associated with creatine kinase elevation, which is a marker of muscle damage. Conclusion This case expands the phenotypic spectrum of TNNT1 myopathy and highlights the importance of genetic testing and counseling for families affected by this rare disorder. In this study provides valuable insights into the genetic basis of NM and highlights the importance of early diagnosis and management for patients with this rare disorder. Further research is needed to better understand the pathophysiology of TNNT1 myopathy and to develop effective treatments for this debilitating condition. Background Nemaline Myopathy (NM) is a rare genetic disorder that affects muscle function and is characterized by the presence of nemaline rods in muscle fibers. These rods are abnormal structures that interfere with muscle contraction and can cause muscle weakness, respiratory distress, and other complications. NM is caused by variants in several genes, including TNNT1, which encodes the protein troponin T1. NM is inherited in an autosomal recessive pattern. The prevalence of heterozygous TNNT1 variants has been reported to be 1/152,000, indicating that the disease is relatively rare. Objective Investigation of TNNT1 gene variants that may cause cretin kinase elevation. Methods Detailed family histories and clinical data were recorded. Whole exome sequencing was performed and family segregation was done by Sanger sequencing. Results In this study, we report a 5-year-old girl with a novel variant recessive congenital TNNT1 myopathy. The patient had a novel homozygous (c.271_273del) deletion in the TNNT1 gene that is associated with creatine kinase elevation, which is a marker of muscle damage. Conclusion This case expands the phenotypic spectrum of TNNT1 myopathy and highlights the importance of genetic testing and counseling for families affected by this rare disorder. In this study provides valuable insights into the genetic basis of NM and highlights the importance of early diagnosis and management for patients with this rare disorder. Further research is needed to better understand the pathophysiology of TNNT1 myopathy and to develop effective treatments for this debilitating condition.

Trace fossils from the Early Silurian Upsalquitch Formation, Upsalquitch Forks-Charlo region, northern New Brunswick, eastern Canada

Jeong Yul Kim(김정률),Ron K. Pickerill(로날드 피커릴),Reg A. Wilson(레지 윌슨) 한국고생물학회 2010 고생물학회지 Vol.26 No.2

캐나다 동부 뉴브런스윅 북쪽의 업살퀴치 포크-칼로 지역에 분포한 실루리아기 후기의 업살퀴치층에서 19속 30종으로 이루어진 다양하고 풍부하며 보존 상태가 양호한 생흔화석이 처음으로 발견되었다. 본 논문에서 체계적으로 기재된 이들 생흔화석은 Acanthorhaphe isp., Calycraterion isp., Chondrites intricatus (Brongniart, 1823), C. targionii (Brongniart, 1823), C. recurvus (Brongniart, 1823), C. isp., Circulichnus montanus Vialov, 1971, Cochlichnus anguineus Hitchcock, 1858, Didymaulichnus lyelli (Roualult, 1850), Furculosus carpathicus Roniewicz and Pie?kowski, 1977, Helminthopsis abeli Ksi??kiewicz, 1977, H. hieroglyphica Heer in Maillard, 1887, Helminthorhaphe isp., Mammillichnis aggeris Chamberlain, 1971, Palaeophycus heberti (de Saporta, 1872), P. tubularis Hall, 1847, Palaeophycus isp., Phycodes palmatus (Hall, 1825), P. templus Han and Pickerill, 1994, Planolites annularius Walcott, 1890, P. beverleyensis (Billings, 1862), P. montanus Richter Rudolf, 1937, P. terraenovae Fillion and Pickerill, 1990, Protovigularia dichotoma McCoy, 1850, P. tuverculata (Williamson, 1887), Rhizocorallium isp., Rusophycus isp., Skolithos verticalis (Hall, 1843), Teichichnus rectus Seilacher, 1955, and Trichophycus isp. 이다. 이생흔화석 중 Calycraterion, Furculosus, Mammillichnis, Phycodes, Planolites, Protovigularia 및 Trichophycus는 실루리아기 지층에서 처음으로 기록된 것이며 Mammillichnis 속은 캐나다에서 처음으로 기록된 것이다. 퇴적 구조와 함께 나타나는 이들 생흔화석은 업살퀴치층이 지금까지 알려진 것보다 매우 다양한 생흔화석으로 이루어진 Zoophycos 생흔상에 해당하는 심해 사면 환경에서 퇴적되었음을 지시한다. A relatively diverse, abundant, and well-preserved trace fossils, consisting of 19 ichnogenera (30 ichnospecies), is discovered for the first time from the Early Silurian Upsalquitch Formation, Upsalquitch Forks-Charlo region, northern New Brunswick, eastern Canada. They are systemically described herein as : Acanthorhaphe isp., Calycraterion isp., Chondrites intricatus (Brongniart, 1823), C. targionii (Brongniart, 1823), C. recurvus (Brongniart, 1823), C. isp., Circulichnus montanus Vialov, 1971, Cochlichnus anguineus Hitchcock, 1858, Didymaulichnus lyelli (Roualult, 1850), Furculosus carpathicus Roniewicz and Pie?kowski, 1977, Helminthopsis abeli Ksi??kiewicz, 1977, H. hieroglyphica Heer in Maillard, 1887, Helminthorhaphe isp., Mammillichnis aggeris Chamberlain, 1971, Palaeophycus heberti (de Saporta, 1872), P. tubularis Hall, 1847, Palaeophycus isp., Phycodes palmatus (Hall, 1825), P. templus Han and Pickerill, 1994, Planolites annularius Walcott, 1890, 1890, P. beverleyensis (Billings, 1862), P. montanus Richter Rudolf, 1937, P. terraenovae Fillion and Pickerill, 1990, Protovigularia dichotoma McCoy, 1850, P. tuverculata (Williamson, 1887), Rhizocorallium isp., Rusophycus isp., Skolithos verticalis (Hall, 1843), Teichichnus rectus Seilacher, 1955, and Trichophycus isp. Of these, Calycraterion isp., Furculosus carpathicus, Mammillichnus aggeris, Phycodes templus, Planolites terraenovae, Protovigularia tuverculata, and Trichonphycus isp. are recorded for the first time from the Silurian deposits and the ichnogenus Mammillichnis is the first record from Canada. These trace fossils associated with sedimentary features suggest that the Upsalquitch Foramation has been deposited in the deep-sea slope environment. This recording also indicates that trace fossils of the ancient slope environment, which corresponds to the archetypal Zoophycos ichnofacies of bathyal environmont, are much more diverse than those currently known.