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Raymundo Ramos Alvarado,Eduardo Castillo Castañeda 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.3
This research introduces a 6-degree-of-freedom parallel manipulator with a reconfigurable fixed base; the manipulator performance has been evaluated to select the most suitable reconfiguration system. The optimal design of the parallel manipulator refers to the enhancement of robot behavior achieved by the geometrical variation of the fixed platform. Motion/force transmission, with the aid of the principle of power conservation, defines the manipulator capacity to transmit its force from the actuated joints to the end-effector from different reconfiguration approaches and vice versa considering the stiffness analysis. Results allow inferring that reconfiguration of the fixed base enhances the performance of this parallel manipulator. The proposal of the reconfiguration system allows obtaining a reconfigurable parallel robot with the minimum number of actuators.
Transgelin (TAGLN) Regulates IQGAP1 and Alters the Functions of Breast Cancer Cells
Bernardo R. Raymundo,오인록,Ling Xiu,김찬화 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.10
Several studies have been conducted on the transgelin (TAGLN) protein and its critical role in cancer biology. However, the regulation of this protein and the way in which this regulation is correlated with the functions of IQ motif-containing GTPase-activating protein 1 (IQGAP1) in MDA-MB231 cells, remain unclear. We generated stable TAGLN-knockdown and TAGLN-overexpressing cells. These cells, along with their control counterparts, were cultured in the presence or absence of 17-AAG. The different cell groups were then subjected to functional assays to assess proliferation, chemotaxis, and invasion. TAGLN regulation was found to affect the efficacy of 17-AAG. The ability of TAGLN to influence the levels of IQGAP1 and its binding partners altered the critical functions of breast cancer cells. Therefore, the altered functionality of MDA-MB-231 cells, as a consequence of TAGLN regulation, is correlated with IQGAP1 signaling.
Bernardo R. Raymundo,오인록,김미정,김찬화 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.12
The role of transgelin (TAGLN) in cancer has been discussed; however, the mechanisms underlying its regulation and correlation with MDA-MB-231 cell plasticity and migratory patterns remain unclear. We generated stable TAGLN-knockdown MDA-MB-231 cells and treated them with phorbol 12-myristate 13-acetate or transforming growth factor (TGF)-?. Chemotaxis, morphology, and invasion were assayed using three-dimensional matrices to evaluate cytoskeletal remodeling and migratory changes. Wound healing assays were conducted using cell inserts. TAGLN knockdown cells exhibited altered morphology due to cytoskeletal remodeling, yet only untreated and TGF?1-treated cells exhibited enhanced migration. Untreated and TGF?1-treated TAGLN knockdown cells showed increased N-WASP, ROCK1, and ROCK2 protein levels, which induce cytoskeletal remodeling. Evaluating phospholipase C?1 (PLC?1)-cofilin signaling-related proteins revealed that only TGF?1-treated TAGLN knockdown cells were influenced by PLC?1-cofilin signaling. Taken together, TAGLN knockdown is necessary for the TGF?1-mediated activation of PLC?1-cofilin pathway-driven amoeboid morphology and enhanced migratory properties in MDA-MB-231 cells.
CORRELATION OF HAIR SHAFT DIAMETER OF GOATS AND THE ROSTRAL GROOVE WIDTH OF THEIR CHEWING LICE
Juancho D.R. Raymundo 국제과학영재학회 2014 APEC Youth Scientist Journal Vol.6 No.2
Host-specificity is an important aspect of parasite diversity. Mammalian chewing lice are highly host-specific ectoparasites that demonstrate adaptive specialization to morphological characteristics of their host, such as hair shaft diameter. Studies have demonstrated a positive correlation between louse head groove width and host hair diameter, suggesting an anatomical relationship that is crucial to louse survival. This study aims to assess the relationship between hair shaft diameters of goats and rostral groove dimensions of the chewing lice that parasitize them. Thirty chewing lice (Damalinia limbata) attached to guard hairs were removed from the nape region of three adult goats of different breeds (Anglo-Nubian, Saanen and Boer), for a total of 90 lice and hair shaft pairs. Rostral groove width and hair shaft diameter were measured using microscopy and MIPro Standard v1.1 image analysis software. The results showed no correlation between the louse rostral groove width and hair shaft diameter. This suggests that goat chewing lice have a rostral groove that allows for attachment to variable host hair shafts, and that hair shaft diameter as a physical adaptive constraint may be less apparent at the level of individual hosts of the same species, providing new insights into host-parasite evolutionary relationships.
오인록,Bernardo Raymundo,Sung A Jung,Hyun Jung Kim,Jung-Keug Park,김찬화 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.8
Extremely low-frequency electromagnetic fields (ELF-EMFs) (1?300?Hz) have been found to have practical applications in biological research. A case in point is the effect of ELF-EMF on the regulation of cell fate. In this study, we investigated the correlation between ELF-EMF stimulation of PPAR? to the stemness, tumorigenicity, and invasiveness of breast cancer stem cells in vitro. The CD44+/CD24? subpopulation of the breast CSCs was isolated from the MDA-MB-231 breast cancer cell line. The CSCs were then exposed to ELF-EMF and further assays were carried out. ELF-EMF increased the expression of PPAR? and other critical proteins leading to cell cycle arrest and reduced stemness as evidenced by decreased expression of stemness genes and reduced proliferation rate in ELF-EMF-exposed CSCs compared to that in nonexposed CSCs. There was a decrease in the tumor-forming and invasion ability of CSCs that were exposed to ELF-EMFs.
Kang Sin Kyu,Ramos Raymundo 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.85 No.1
We propose a model that simultaneously addresses the existence of a dark matter candidate, baryon asymmetry and tiny neutrino masses and mixing by introducing two SU(2) triplet scalars and an inert SU(2) doublet scalar on top of the standard model. The two triplet scalars serve as mediators in generation of lepton asymmetry and determination of relic density of dark matter. They also play an essential role in the generation of tiny neutrino masses and inducing CP violation. The inert scalar is regarded as a dark matter candidate. The interference due to complex Breit–Wigner propagators for the triplets will result in CP-asymmetry that depends on the diference between their masses and a relative complex phase between their couplings to standard model leptons. Moreover, the production of lepton asymmetry will be closely tied to the evolution of dark matter, limiting the parameter space where the correct relic abundance and matter–antimatter asymmetry can be simultaneously accomplished.