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Molecular imaging of atherosclerosis using reporter gene system
Ran Ji Yoo1,Yong Jin Lee 대한방사성의약품학회 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.1
Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using 99mTc-SPECT. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.
이애란,고동완,김유일 성균관대학교 생명과학자원연구소 1996 生命資源科學硏究 Vol.2 No.2
The city's countryside is adjusting to change by urbanisation. As it, the recent phenomena in this area decline in rural landuse and damage of landscape which has local characteristics. But, no study think together landuse and landscape at present in this area. The aim of this study was to clarify causes and problems of change by investigating intersection of environments and causes, processes and results of landuse and landscape in city's countryside. The sites are 2 Up and 2 Myon belong to Yongin Gun closed by Seoul City. These site are rapidly changed and almost intermediate between city and rural at present. As methods, I exeminated not only various statistical data but also unstatistical data. This case study revealed the diversity of change in city's countryside. 1) The change of landuse is clarified by Local Main commercial district is Yongin Up, Development of Traffic and industry is Kihung Up, Bed-town closed by city is Suji Myon and Recreation development is Pogok Myon. Each landuse divided by landscape types as local diversity in several Ri. Also each case seperatied by its special shape from each Ri and have causes and problems. 2) From these results did I point out problems and make a proposal about national landuse plan and landscape management in city's countryside. It stressed the need of a long-ranged policy of development in countryside considering local characteristics and residential environments. This paper was the start of case study about landuse and landscape in city's countryside.
Somatic mutations of the <i>KEAP1</i> gene in common solid cancers
Yoo, Nam Jin,Kim, Hyung Ran,Kim, Yoo Ri,An, Chang Hyeok,Lee, Sug Hyung Blackwell Publishing Ltd 2012 Histopathology Vol.60 No.6
<P>Yoo N J, Kim H R, Kim Y R, An C H & Lee S H (2012) <I>Histopathology</I>?<B>60,</B> 943–952</P><P><B>Somatic mutations of the <I>KEAP1</I> gene in common solid cancers</B></P><P><B>Aims: </B> KEAP1 inhibits nuclear factor erythroid 2‐related factor 2 (NRF2)‐induced cytoprotection, and is considered to be a candidate tumour suppressor. Somatic mutation of <I>NRF2</I> has been analysed in a wide variety of human cancers, whereas somatic mutation of <I>KEAP1</I> has been reported only in lung and gall bladder cancers. The aim of our study was to investigate whether <I>KEAP1</I> mutations are widespread in human cancers.</P><P><B>Methods and results: </B> We analysed 499 cancer tissues from lung, breast, colon, stomach, liver, larynx and prostate, and leukaemias, by single‐strand conformation polymorphism analysis. We detected somatic mutations of <I>KEAP1</I> in gastric (11.1%), hepatocellular (8.9%), colorectal (7.8%), lung (4.6%), breast (2.0%) and prostate (1.3%) carcinomas. Allelic losses of the <I>KEAP1</I> locus were identified in 42.9% of cancers with <I>KEAP1</I> mutations, but no <I>NRF2</I> mutations were detected in these cancers. The NRF2‐activated cytoprotective proteins (NAD(P)H dehydrogenase quinone 1 and glutamine‐cysteine ligase catalytic subunit) were expressed in all of the cancers with <I>KEAP1</I> mutations.</P><P><B>Conclusions: </B> Our data show that <I>KEAP1</I> mutations occur widely in solid cancers, irrespective of histological type. Biallelic inactivation of <I>KEAP1</I> and increased levels of cytoprotective proteins in the cancers suggest that <I>KEAP1</I> mutations might protect cancer cells from oxidative insults and play a role in the development of solid cancers.</P>
High sensitivity in Al-doped ZnO nanoparticles for detection of acetaldehyde
Yoo, Ran,Li, Dongmei,Rim, Hyun Jun,Cho, Sungmee,Lee, Hyun-Sook,Lee, Wooyoung Elsevier 2018 Sensors and actuators. B Chemical Vol.266 No.-
<P><B>Abstract</B></P> <P>The gas sensing properties of Al-doped ZnO nanoparticles (NPs), which were synthesized via a hydrothermal method, have been described for the detection of volatile organic compounds (VOCs) such as acetaldehyde, toluene, and benzene. The maximum sensing response (R = 2250) of these Al-doped ZnO NPs was observed upon exposure to 10 ppm acetaldehyde at an optimal operating temperature of 500 °C, which was almost 173 and 125 times higher than that observed for toluene and benzene, respectively. The highest dipole moment of acetaldehyde among the three VOCs is responsible for its highest sensitivity. The Al-doped ZnO NPs also show a higher selectivity toward acetaldehyde than that of different interfering gases and their response to acetaldehyde was superior compared with the previously reported responses of other materials. The enhanced sensing performance of Al-doped ZnO NPs to acetaldehyde compared to undoped ones may be explained by an increase in specific surface area, oxygen vacancies, and conductivity after Al doping.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Yoo, Ran Ji,Lee, Ji Woong,Lee, Kyo Chul,An, Gwang Il,Ko, In Ok,Chung, Wee Sup,Park, Ji Ae,Kim, Kyeong Min,Choi, Yang-Kyu,Kang, Joo Hyun,Lim, Sang Moo,Lee, Yong Jin 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2
$^{64}Cu$-labeled diacetyl-bis($N^4$-methylthiosemicarbazone) is a promising agent for internal radiation therapy and imaging of hypoxic tissues. In the study, we confirmed hypoxia regions in VX2 tumor implanted rabbits with injection $^{64}Cu$-ATSM and $^{18}F$-FDG using positron emission tomography (PET)/computed tomography (CT). PET images with $^{18}F$-FDG and $^{64}Cu$-ATSM were obtained for 40 min by dynamic scan and additional delayed PET images of $^{64}Cu$-ATSM the acquired up to 48 hours. Correlation between intratumoral $O_2$ level and $^{64}Cu$-ATSM PET image was analyzed. $^{64}Cu$-ATSM and $^{18}F$-FDG were intravenously co-injected and the tumor was dissected and cut into slices for a dual-tracer autoradiographic analysis. In the PET imaging, $^{64}Cu$-ATSM in VX2 tumors displayed a specific uptake in hypoxic region for48 h. The uptake pattern of $^{64}Cu$-ATSM in VX2 tumor at 24 and 48 h did not match to the $^{18}F$-FDG. Through ROI analysis, in the early phase (dynamic scan), $^{18}F$-FDG has positive correlation with $^{64}Cu$-ATSM but late phase (24 and 48 h) of the $^{64}Cu$-ATSM showed negative correlation with $^{18}F$-FDG. High uptake of $^{64}Cu$-ATSM in hypoxic region was responded with significant decrease of oxygen pressure, which confirmed by $^{64}Cu$-ATSM PET imaging and autoradiographic analysis. In conclusion, $^{64}Cu$-ATSM can utilize for specific targeting of hypoxic region in tumor, and discrimination between necrotic- and viable hypoxic tissue.
Molecular imaging of atherosclerosis using reporter gene system
Yoo, Ran Ji,Lee, Kyochul,Kang, Joo Hyun,Lee, Yong Jin Korean Society of Radiopharmaceuticals and Molecul 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.1
Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using $^{99m}Tc-SPECT$. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.