http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ma, R. C. W.,Hu, C.,Tam, C. H.,Zhang, R.,Kwan, P.,Leung, T. F.,Thomas, G. N.,Go, M. J.,Hara, K.,Sim, X.,Ho, J. S. K.,Wang, C.,Li, H.,Lu, L.,Wang, Y.,Li, J. W.,Wang, Y.,Lam, V. K. L.,Wang, J.,Yu, W.,Ki Springer-Verlag 2013 Diabetologia Vol.56 No.6
<P><B>Aims/hypothesis</B></P><P>Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians.</P><P><B>Methods</B></P><P>We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations.</P><P><B>Results</B></P><P>We identified <I>CDKN2A/B</I> and four novel type 2 diabetes association signals with <I>p</I> < 1 × 10<SUP>−5</SUP> from the meta-analysis. Thirteen variants within these four loci were followed up in two independent Chinese cohorts, and rs10229583 at 7q32 was found to be associated with type 2 diabetes in a combined analysis of 11,067 cases and 7,929 controls (<I>p</I><SUB>meta</SUB> = 2.6 × 10<SUP>−8</SUP>; OR [95% CI] 1.18 [1.11, 1.25]). In silico replication revealed consistent associations across multiethnic groups, including five East Asian populations (<I>p</I><SUB>meta</SUB> = 2.3 × 10<SUP>−10</SUP>) and a population of European descent (<I>p</I> = 8.6 × 10<SUP>−3</SUP>). The rs10229583 risk variant was associated with elevated fasting plasma glucose, impaired beta cell function in controls, and an earlier age at diagnosis for the cases. The novel variant lies within an islet-selective cluster of open regulatory elements. There was significant heterogeneity of effect between Han Chinese and individuals of European descent, Malaysians and Indians.</P><P><B>Conclusions/interpretation</B></P><P>Our study identifies rs10229583 near <I>PAX4</I> as a novel locus for type 2 diabetes in Chinese and other populations and provides new insights into the pathogenesis of type 2 diabetes.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00125-013-2874-4) contains peer-reviewed but unedited supplementary material, which is available to authorised users.</P>
Design of the Advanced Metadata Service System with AMGA for the Belle II Experiment
S. Ahn,K. Cho,S. Hwang,J. Kim,H. Jang,B. K. Kim,H. Yoon,J. Yu,Z. Drasal,T. Hara,Y. Iida,R. Itoh,G. Iwai,N. Katayama,Y. Kawai,S. Nishida,T. Sasaki,Y. Watase,R. Fruhwirth,W. Mitaroff,R. Grzymkowski,M. S 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.57 No.4
The Belle II experiment is expected to produce 50 times more data than the existing Belle experiment. Such huge data production requires not only scalability with respect to the storage service but also scalability regarding the metadata service. There has already been a metadata service at the Belle experiment, but it is not proper for the Belle II experiment because it has scalability problems and it is not intended to be used in a distributed grid environment. To deal with these issues, we designed an advanced metadata service system based on AMGA, which provides efficient and scalable metadata searching. We have built testbed sites to test the correctness, performance and scalability of the advanced metadata service system, and it has been proved to be able to provide efficient metadata searching for the Belle II experiment.
Kawai, Y,Osawa, T,Kobayashi, K,Inoue, R,Yamamoto, Y,Matsumoto, H,Nagao, K,Hara, T,Sakano, S,Nagamori, S,Matsuyama, H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: Factors predictive of survival have been identified in Western patients with metastatic clear cell renal cell carcinoma (mCCRCC) treated with sunitinib. Less is known, however, about factors predictive of survival in Japanese patients. This study evaluated factors prognostic of survival in Japanese patients with mCCRCC treated with first-line sunitinib. Materials and Methods: This retrospective study evaluated 46 consecutive Japanese mCCRCC patients treated with sunitinib as first line therapy. Clinical and biochemical markers associated with progression-free survival (PFS) were analyzed, with prognostic factors selected by uniand multivariate Cox regression analyses. Results: Univariate analysis showed that factors significantly associated with poor PFS included Memorial Sloan-Kettering Cancer Center poor risk scores, International Metastatic RCC Database Consortium poor risk and high (>0.5 mg/dl) serum C-reactive protein (CRP) concentrations (p<0.001 each). Multivariate analysis showed that high serum CRP was independently associated with poorer PFS (p=0.040). Six month disease control rate (complete response, partial response and stable disease) in response to sunitinib was significantly higher in patients with normal (${\leq}0.5mg/dl$) than elevated baseline CRP (p<0.001). Conclusions: CRP is a significant independent predictor of PFS for Japanese patients with mCCRCC treated with first-line sunitinib. Pretreatment CRP concentration may be a useful biomarker predicting response to sunitinib treatment.
S. Nagini,K.V.P. Chandra Mohan,R. Subapriya,Y. Hara 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
We evaluated the comparative chemopreventive efficacy of green tea polyphenols (polyphenon-E) and blacktea polyphenols (polyphenon-B) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcino-genesis. Lipid peroxidation, reduced and oxidized glutathione (GSH and GSSG, respectively), and the GSH-dependent en-zymes glutathione peroxidase and glutathione S-transferase in the erythrocytes were used as biomarkers of chemoprevention.Enhanced lipid peroxidation in erythrocytes of DMBA-treated animals was accompanied by a significant decrease in the an-tioxidant status. Dietary administration of polyphenon-E and -B to DMBA-treated animals significantly decreased the extentof lipid peroxidation and enhanced the levels of GSH, GSH/GSSG ratio, and activities of GSH-dependent enzymes. Our studyprovides evidence that polyphenon-B is more effective in inhibiting HBP carcinogenesis than polyphenon-E by enhancing theantioxidant status, suggesting that polyphenon-B may have a major impact in the chemoprevention of oral cancer.
Adjustment Procedure for Beam Alignment in Scanned Ion-Beam Therapy
Y. Saraya,E. Takeshita,T. Furukawa,Y. Hara,K. Mizushima,N. Saotome,R. Tansho,T. Shirai,K. Noda 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.6
Control of the beam position for three-dimensional pencil-beam scanning is important because the position accuracy of the beam significantly impacts the alignment of the irradiation field. To suppress this effect, we have developed a simple procedure for beamline tuning. At first, beamline tuning is performed with steering magnets and fluorescent screen monitors to converge the beam’s trajectory to a central orbit. Misalignment between the beam’s position and the reference axis is checked by using the verification system, which consists of a screen monitor and an acrylic phantom. If the beam position deviates from the reference axis, two pairs of steering magnets, which are placed on downstream of the beam transport line, will be corrected. These adjustments are iterated until the deviations for eleven energies of the beam are within 0.5 mm of the reference axis. To demonstrate the success of our procedure, we used our procedure to perform beam commissioning at the Kanagawa Cancer Center.
Horikoshi, Momoko,Pasquali, Lorenzo,Wiltshire, Steven,Huyghe, Jeroen R.,Mahajan, Anubha,Asimit, Jennifer L.,Ferreira, Teresa,Locke, Adam E.,Robertson, Neil R.,Wang, Xu,Sim, Xueling,Fujita, Hayato,Hara IRL Press 2016 Human molecular genetics Vol.25 No.10
<P>To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (<I>CDKAL1</I>, <I>CDKN2A-B</I>, <I>IGF2BP2</I> and <I>KCNQ1</I>) are mediated, we undertook transancestral fine-mapping in 22 086 cases and 42 539 controls of East Asian, European, South Asian, African American and Mexican American descent. Through high-density imputation and conditional analyses, we identified seven distinct association signals at these four loci, each with allelic effects on T2D susceptibility that were homogenous across ancestry groups. By leveraging differences in the structure of linkage disequilibrium between diverse populations, and increased sample size, we localised the variants most likely to drive each distinct association signal. We demonstrated that integration of these genetic fine-mapping data with genomic annotation can highlight potential causal regulatory elements in T2D-relevant tissues. These analyses provide insight into the mechanisms through which T2D association signals are mediated, and suggest future routes to understanding the biology of specific disease susceptibility loci.</P>