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Involvement of Nitric Oxide in UVB-induced pigmentation
Horikoshi, Toshio,Sasaki, Minoru,Nakahara, Michio,Uchiwa, Hideyo,Miyachi, Yoshiki Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Nitric oxide (NO) is a newly described transmitter involved with cell to cell communication that is generated in biologic tissues by specific types of nitric oxide synthase (NOS), which metabolize L-arginine and molecular oxygen to citrulline and nitric oxide. In the skin. NO has been reported to play an important role in such diseases as psoriasis, atopic dermatitis, and contact dermatitis, as well as act as an important modulator in UVB-induced erythema. Ultraviolet B irradiation to the skin evokes an increase in NO production in the epidermis through two pathways; induction of inducible NOS, mediated by inflammatory cytokines, and elevation of constitutive neuronal NOS activity. In a cell culture system, it has been demonstrated that NO functions as a melanogen after being produced in keratinocytes in response to UVB-irradiation. NO-stimulated melanogenesis in melanocytes is mediated by the cGMP/PKG pathway. In this study, up-regulation of tyrosinase gene expression by NO-stimulation and the involvement of NO in UVB-induced pigmentation were examined. In NO-induced melanogenesis, protein synthesis and tyrosinase activity increased along with an up-regulation of tyrosinase gene expression. In an animal model, UVB-induced pigmentation in skin was suppressed by sequential daily treatments with a specific inhibitor of NOS. Thus, NO plays an important role in UVB-induced pigmentation, where its function as a melanogen is considered to be one of the mechanisms. Together with its role in the development of erythema, NO contributes to the total protective response of skin against UVB-irradiation.
Horikoshi, Momoko,Pasquali, Lorenzo,Wiltshire, Steven,Huyghe, Jeroen R.,Mahajan, Anubha,Asimit, Jennifer L.,Ferreira, Teresa,Locke, Adam E.,Robertson, Neil R.,Wang, Xu,Sim, Xueling,Fujita, Hayato,Hara IRL Press 2016 Human molecular genetics Vol.25 No.10
<P>To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (<I>CDKAL1</I>, <I>CDKN2A-B</I>, <I>IGF2BP2</I> and <I>KCNQ1</I>) are mediated, we undertook transancestral fine-mapping in 22 086 cases and 42 539 controls of East Asian, European, South Asian, African American and Mexican American descent. Through high-density imputation and conditional analyses, we identified seven distinct association signals at these four loci, each with allelic effects on T2D susceptibility that were homogenous across ancestry groups. By leveraging differences in the structure of linkage disequilibrium between diverse populations, and increased sample size, we localised the variants most likely to drive each distinct association signal. We demonstrated that integration of these genetic fine-mapping data with genomic annotation can highlight potential causal regulatory elements in T2D-relevant tissues. These analyses provide insight into the mechanisms through which T2D association signals are mediated, and suggest future routes to understanding the biology of specific disease susceptibility loci.</P>
Horikoshi, Satoshi,Tsuchida, Akihiro,Sakai, Hideki,Abe, Masahiko,Sato, Susumu,Serpone, Nick Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.11
A metallic condensing cone that concentrates microwave radiation (equivalent to an optical lens) has been developed and used as part of a system to activate a microwave discharge electrodeless lamp (MDEL) in the oxidative treatment of wastewaters by aiding the novel self-ignition of the lamp on irradiation at low microwave power levels. This approach to self-ignition can potentially lead to considerable energy savings in such treatments. System performance was examined for the ignition power of microwaves of such MDEL devices in water, whose usefulness was assessed by investigating the photolytic transformation of aqueous solutions of representatives of three classes of contaminants: chlorinated phenols, herbicides and endocrine disruptors, specifically 4-chlorophenol (4-CP), 2,4-dichlorophenoxyacetic acid (2,4-D) and 4,4'-isopropylidenediphenol (bisphenol-A; BPA), respectively, taken as model wastewaters in air-equilibrated, in oxygen-saturated and in $TiO_2$-containing aqueous media. The results are discussed in terms of the dynamics of the photo-induced degradation processes.
Horikoshi, Satoshi,Abe, Masahiko,Serpone, Nick Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.8
Novel light sources based on microwave discharge electrodeless lamps (MDEL) are examined as potential light sources to drive photochemical processes, in particular advanced oxidation processes (AOPs) of which various applications are described. The MDELs possess several features that make them attractive as possible environmental remediation lamps and as light sources to activate metal oxide photocatalysts in environmental remediation processes. Accordingly, the article describes some of the many features, albeit non-exhaustively, of MDEL devices and reports some photoreactors that incorporate these MDELs. Fundamental issues of MDEL light sources in remediation processing of actual pollutants are introduced. Examples are taken from the oxidative destruction of volatile organic compounds (VOCs; e.g. acetaldehyde and toluene), from the oxidative degradation of contaminants present in wastewaters (e.g. the 2,4-D herbicide and the endocrine disruptor bisphenol-A) and from the remediation of dioxin-contaminated fly-ash, along with an actual industrial wastewater sample from the manufacturing of cement.
Philosophical Practices in Japan from School to Business Consultancy
( Yosuke Horikoshi ),( Tetsuya Kono ) 한국철학상담치료학회 2020 철학 실천과 상담 Vol.10 No.-
This article aims to introduce the recent movements regarding philosophical practice in Japan. In order to understand them in a better way, the historical development and background of philosophical practice shall be shown briefly in the first part. In the second part, three cases of relatively popular philosophical practices in Japan, that is, philosophy cafe, philosophy for/with children and philosophical consulting in the business settings are described as successful practices.
Philosophical Practices in Japan from School to Business Consultancy
Yosuke Horikoshi,Tetsuya Kono 한국철학상담치료학회 2020 철학 실천과 상담 Vol.10 No.-
This article aims to introduce the recent movements regarding philosophical practice in Japan. In order to understand them in a better way, the historical development and background of philosophical practice shall be shown briefly in the first part. In the second part, three cases of relatively popular philosophical practices in Japan, that is, philosophy cafe, philosophy for/with children and philosophical consulting in the business settings are described as successful practices.