Effects on MATSA-bearing cells in Marek`s Disease

Lee, Woo Yong,Sah, R. L.,Pradhan, H. K.,Mohanty, G. C. 한국수의공중보건학회 1989 예방수의학회지 Vol.13 No.3

Valorization of lignocellulosic fibres of paper waste into levulinic acid using solid and aqueous Brønsted acid

Chen, Season S.,Wang, Lei,Yu, Iris K.M.,Tsang, Daniel C.W.,Hunt, Andrew J.,Jé,rô,me, Franç,ois,Zhang, Shicheng,Ok, Yong Sik,Poon, Chi Sun Elsevier 2018 Bioresource technology Vol.247 No.-

<P><B>Abstract</B></P> <P>This study aims to produce levulinic acid (LA) from paper towel waste in environment-friendly and economically feasible conditions, and evaluate the difference using solid and aqueous Brønsted acids. Direct dehydration of glucose to LA required sufficiently strong Brønsted acidity, where Amberlyst 36 demonstrated rapid production of approximately 30Cmol% of LA in 20min. However, the maximum yield of LA was limited by mass transfer. In contrast, the yield of LA gradually increased to over 40Cmol% in 1M H<SUB>2</SUB>SO<SUB>4</SUB> at 150°C in 60min. The SEM images revealed the conversion in dilute acids under microwave at 150°C resulting in swelling structures of cellulose, which were similar to the pre-treatment process with concentrated acids. Further increase in reaction temperature to 200°C significantly shortened the reaction time from 60 to 2.5min, which saved the energy cost as revealed in preliminary cost analysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 30% of levulinic acid (LA) yielded from paper towel over Amberlyst 36 in 20min. </LI> <LI> Maximum yield of LA was comparable using dilute sulphuric acid at 150 and 200°C. </LI> <LI> Cellulose underwent swelling in dilute acid with microwave heating at 150°C. </LI> <LI> Conversion at 200°C shortened reaction time and reduced total energy consumption. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

In vitro release and skin permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles

( R K Thapa ),( R Baskaran ),( T Madheswaran ),( J O Kim ),( C S Yong ),( B K Yoo ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

The objective of the present study was to determine the effect of different ratios of monoolein and oleic aciad on in vitro release and ski permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles. The nanoparticles were prepared by sonicating a mixture of melted monoolein, poloxamer 407, oleic acid and tacrolimus to which distilled water was added. Formation of cubosomes and hexosomes was confirmed by transmission electron microscopy and optical microscopy, and average particle size of the formulations was about 150-200 nm. The encapsulation effeciency for tacrolims in all the formulations was > 99%. In vitro retro release of the drug was proportionally reduced by the amount of monoolein used. Addition of oleic acid further reduced the tacrolimus release. The skin permeation was also in agreement with the vitro release. This study provides a strategy to control the release and skin permeation of tacrolimus from nanoparticles, thus expanding the area of tacrolimus usage.

Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles

( R K Thapa ),( R Baskaran ),( T Madheswaran ),( J Y Rhyu ),( J O Kim ),( C S Yong ),( B K Yoo ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

Liquid crystalline nanoparticles are unique structures that can be used in the delivery of a wide range of pharmaceutical actives. Herein, we studied the effect of saturated fatty acids on tacrolimus-loaded monoolein liquid crystalline nanoparticles stabilized with poloxamer 407, Char-acterization of nanoparticles included optical and transmission electron microscopy, particle size, and entrapment efficiency analysis. Microscope data suggested the formation of cubosomes for monoolein dispersions, and of hexosomes for monoolein-fatty caid systems. Entrapment efficiency of tacrolimus was as high as 99% or above. In vitro release study revealed that amount of monoolein and carbon chain lengths of the fatty acid were the factors that affected drug release from the liquid crystalline nanoparticles. Notably, monoolein-fatty acid systems prepared with short chain length, such as lauric and myristic acid, showed markedly sustained release profile of the drug. Hence, appropriate selection of fatty acid can be exploited to achieve desired release profile from monooloein liquid crystalline nanoparticles.

Structural and electrical properties of polycrystalline CdTe films for direct X-ray imaging detectors

Cha, B.K.,Yang, K.,Cha, E.S.,Yong, S.M.,Heo, D.,Kim, R.K.,Jeon, S.,Seo, C.W.,Kim, C.R.,Ahn, B.T.,Lee, T.B. North-Holland 2013 Nuclear instruments & methods in physics research. Vol.731 No.-

We introduce polycrystalline cadmium telluride (CdTe) with high atomic number and density, low effective energy and wide band gap for application in large area diagnostic X-ray digital imaging. In this work, polycrystalline CdTe films were fabricated on ITO/glass substrate by both physical vapor deposition (PVD) with slow deposition rate and pressure of 10<SUP>-6</SUP>Torr and the closed space sublimation (CSS) method with high deposition rate and low vacuum pressure(10<SUP>-2</SUP>Torr). The various polycrystalline CdTe films were grown at different deposition rates and substrate temperatures. Physical properties such as microstructures and the crystal structure of the polycrystalline samples were investigated by SEM and XRD patterns respectively. The PVD method resulted in microstructures with columnar shape and more uniform surface, while the CSS method produced microstructures with many larger grains and less uniform surface. The films were polycrystalline structures with a preferential (111) direction. The electrical and optical properties such as the dark current as a function of applied bias voltage and X-ray sensitivity of the fabricated films were measured and investigated under X-ray exposure.

BRIEF REPORTS ON KAISTSAT-4 MISSION ANALYSIS

J. Seon,K. I. Seon,S. H. Kim,K. W. Min,B. J. Kim,R. C. K. Yong,L. F. Leong,H. J. Chun,H. S. Chang,H. S. Kim,J. S. Bae,Y. W. Choi,S. R. LEE,Y. H. Shin,K. S. Ryu,J. J. Lee,D. H. Lee,D. J. Park 한국우주과학회 2000 Journal of Astronomy and Space Sciences Vol.17 No.2

Hydraulics of KSTAR Central Solenoid Model Coil 2nd Campaign

Soo Hwan Park,Han, W.S.,Moon, K.M.,Park, W.W.,Kim, J.S.,Yonekawa, H.,Yong Chu,Hyun Jung Lee,Cho, K.W.,Park, K.R.,Kim, W.C.,Yaung-Soo Kim,Oh, Y.K.,Bak, J.S. IEEE 2009 IEEE transactions on applied superconductivity Vol.19 No.3

<P>KSTAR (Korea Superconducting Tokamak Advanced Research) superconducting magnet consists of a CICC (Cable-In-Conduit Conductor) and is cooled down less than 5 K using supercritical helium. The length of CICC is 610 m for TF coil and maximum about 2,500 m for PF coil respectively, especially the cooling channel is about maximum 300 m in PF coil because of continuous winding scheme. There are many cooling channels in KSTAR coils especially 84 channels in TF magnet system and 100 channels in PF magnet system. Flow imbalance affects cool down of magnet and leads to a difficulty of flow control. The pressure drop between CICC terminals has a close relationship with CICC hydraulic characteristic, helium refrigerator's performance and efficiency. The friction factor which is a representative parameter can be obtained under cryogenic operation condition. We attempt to find out the friction factor of KSTAR CS and PF CICC according to the test result of KSTAR CSMC (Central Solenoid Model Coil) 2nd campaign and compare the results with previous tests. The hydraulic characteristics of KSTAR superconducting magnet system like mass flow distribution, friction factor in conductor, pressure drop and etc during CSMC test and initial commissioning of KSTAR are presented. We can confirm the KSTAR CICC's unique hydraulic behavior in states of cool down and current charging period. Also, we expect that measured data will help to operate KSTAR and be a reference for thermo-hydraulic simulation.</P>

Nano-mechanical Properties of API-X80 Steel Sheet after HIC

Ma R. Kim,Yong Choi(최용),W. K. Kim,C. S. Lee 한국표면공학회 2016 한국표면공학회 학술발표회 초록집 Vol.2016 No.5

Graphene oxide-wrapped PEGylated liquid crystalline nanoparticles for effective chemo-photothermal therapy of metastatic prostate cancer cells

Thapa, R.K.,Youn, Y.S.,Jeong, J.H.,Choi, H.G.,Yong, C.S.,Kim, J.O. Elsevier 2016 Colloids and surfaces. B, Biointerfaces Vol.143 No.-

<P>Here, we report the preparation of PEGylated liquid crystalline nanoparticles (LCN) loaded with docetaxel (DTX) and wrapped with graphene oxide (GO), called PEG-GO/LCN/DTX, for effective chemo-photothermal therapy of metastatic prostate cancer cells. The prepared formulation exhibited a small particle size (<250 nm), high drug loading capacity (similar to 15%), and efficient near infrared (NIR) light-induced thermal heat. Importantly, PEG-GO/LCN/DTX successfully accumulated in prostate cancer cells and exhibited potent apoptotic and antimigration effects, mediated by the combination of the anticancer effects of DTX and the thermal heat induced by exposure of GO to NIR light. Taken together, our findings support that PEG-GO/LCN/DTX may be an effective system for treatment of metastatic prostate cancer. Moreover, the results establish a proof-of-concept for the potential chemo-photothermal functionality of PEG-GO/LCN/DTX. This hybrid system of LCN and GO could provide controlled and targeted drug delivery with enhanced NIR-induced thermal effects for effective treatment of metastatic cancers. (C) 2016 Elsevier B.V. All rights reserved.</P>

Field Operational Research on the Control of Paragonimiasis in Korea

Lee, K.T,Chung, P.R,MIn, H.K,Ahn, Y.K,Min, D,Y,Soh, C.T,Lee, J.H,Yong, T.S,Chang, D.H,Kang, J.S INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1986 YONSEI REPORTS ON TROPICAL MEDICINE Vol.17 No.1

폐흡충증의 관리를 위한 효과적인 방법을 모색하고자 1983년부터 1985년까지 전라남도 완도군 노화읍 보길도의 부용리와 부황리를 대상지역으로 하여 관리사업지역과 인근의 정자리를 대조지역으로 각각 선정하여 폐흡충증의 역학적 조사, 집단치료, 중간숙주 및 보충숙주에 대한 연구 그리고 보건교육 등을 체계적으로 실시하여 그 결과를 분석하여 우리나라 폐흡충관리사엽의 지표를 삼고자하였다. 1. 사업 첫해인 1983년 7월, 폐흡충증의 피내반응 검사결과 양성률은 33.5%(총 검사자 656명 중 220명)였으며 남자들 중에서 40대 연령군에서 양성률이 58.1%로 가장 높았다. 분변과 객담검사상 충란 양성자는 총피검사 366명 중 12명 (3.3%)이었다. 이듬해인 1984년 7월에는 피내반응 양성률이 25.4%로 감소했으며 충란양성자는 발견되지 않았다. 한편 대조부락에 있어서 피내반응검사 양성률은 9.9%(총 피검자 151명 중 15명)였으며 충란양성자는 없었다. 2. 총 12명의 충란양성자 중에서 6명은 과거 가재를 먹은 경험이 있었다. 이들이 호소한 증세는 기침과 혈액성 또는 점성 객담이 85%로 가장 높았다, 비린내(33.3%), 권태(11.1%) 및 호흡곤란(11.1%)의 순이었다. X-ray 검사상 뚜렷한 감염병소는 관찰되지 않았다. 3. 총 12명의 충란양성자와 피내반응 검사상 양성을 나타낸 아동 57명에 프라지칸텔을 체중 ㎏당 1일 75㎎씩 2일간 투약하였다. 투약 1년후 충란양성자 12명 중 11명을 (1명은 투약후 마을을 떠남) 대상으로 객담과 분변검사를 한 바 충란양성자는 발견되지 않았다. 4. 1983년과 1985년에 대상지역에서 채집한 폐흡충의 제1중간숙주인 다슬기(Semisulcospira libertina)를 조사한 바 유미유충을 배출하는 다슬기는 없었다. 5. 연구기간 중 대상지역의 제 2중간숙주인 가재(Cambaroids similis)의 감염률을 조사한 바 63.2%(582마리 중 368마리)가 감염되어 있었으며 가재당 평균 피낭유층의 수는 17.5마리였다. 폐흡충 관리사업 실시후 가재의 감염률은 차이가 없었으나 가재당 감염 피낭유충의 평균은 1983년에 17.3마리에서 1975년에 6.5마리로 감소되었다. 6. 가축 중에서 보충숙주는 관찰되지 않았다. 7. Enzyme-linked immunosorbent assay(ELISA)는 폐흡충증 진단에 있어서 감수성은 94.7%, 특이성은 100%로 나타났다. 결론적으로 마을 단위에서 집단투약, 보건교육, 생활환경개선, 보건감시망 체제와 같은 장기적이고 체계적인 노력이 폐흡충증의 이환률 및 감염률을 낮출 수 있을 것으로 생각되며 본 연구 역시 이러한 관리 방안에 대한 기초자료를 제공하였다고 생각된다. 집단 투약은 유병률을 낮추는데 있어 여러 가지 방법 중 가장 중요한 방법으로 여겨지나, 환경위생의 개선이 수반되어야 할 것으로 생각된다.