Protective Effects of Kolaviron on Diclofenac-Induced Hepatotoxicity in Rats

( Quadri Alabi ),( Rufus Akomolafe ),( Olaoluwa Olukiran ),( Modinat Adefisayo ),( Aliyat Nafiu ),( Joseph Omole ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The present study was carried out to evaluate the protective effects of kolaviron (KV), a biflavonoid from Garcinia kola seeds on diclofenac-induced hepatic injury in Wistar rats. Methods: Twenty-five male Wistar rats were divided into 5 groups of 5 animals each. Group 1 (control) received propylene glycol at 2 ml/kg orally for 28 days. Group 2 received 10 mg/kg of diclofenac (DCLF) (i.m) for 7 days. Groups 3 and 4 received KV orally at 100 and 200 mg/kg respectively for 28 days and subsequently treated with DCLF for 7 days. Group 5 received Livolin Forte (a reference drug) orally at 5.2 mg/kg for 28 days and DCLF for 7 days. At the end of the study, all the rats were sacrificed under ketamine anesthetic, 24 hours after treatment. Pro-inflammatory cytokines level, markers of liver function, oxidative stress and histopathological alterations were evaluated. Results: DCLF caused significant increase in the plasma activities of liver enzymes, including bilirubin level, pro-inflammatory cytokine and NF-kB when compared with the control (P<0.05). It also caused significant alteration in antioxidant status of the rats. It caused distortion of the liver histoarchitecture of the rats. However, kolaviron significantly prevented or reduced (P<0.05) the alterations caused by DCLF in the plasma and liver of the rats pre-treated with KV before DCLF administration. Conclusions: KV exhibited a protective properties against DCLF-induced hepatotoxicity, due to its antioxidant and anti-inflammatory effects. It appears to be as effective as Livolin Forte in attenuating DCLF-induced hepatotoxicity in rats.

Impact of Curing Condition on Compressive Strength of Biopolymer Treated Soil

Quadri Olakunle Babatunde,Dong Geon Son,Yoon Geom Heo,Yong-Hoon Byun 대한토목학회 2022 대한토목학회 학술대회 Vol.2022 No.10

A CONDITION FOR THE COMMUTATIVITY OF RINGS

Quadri, Murtaza A.,Ashraf, Mohd. Department of Mathematics 1987 Kyungpook mathematical journal Vol.27 No.2

In the present paper a result [10] of the authors has been generalized as follows: Let l, m, n be fixed positive integers and R be a semi prime ring in which $[(xy)^l,(xy)^m-(yx)^n]=0$ for all $x,y{\in}R$, then R is commutative.

Oral Squamous Cell Carcinoma and Associated Risk Factors in Jazan, Saudi Arabia: A Hospital Based Case Control Study

Quadri, Mir Faeq Ali,Alharbi, Fahd,Bajonaid, Amal Mansoor S,Moafa, Ibtisam Hussain Y,Sharwani, Abubakker Al,Alamir, Abdulwahab Hussain A Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Background: Oral cancer is the third most common malignancy in Saudi Arabia, the highest incidence of which is reported from Jazan province. The objective of this study was to evaluate the association of various locally used substances, especially shamma, with oral cancer in the Jazan region of Saudi Arabia. Materials and Methods: A hospital-based case-control study was designed and patient records were scanned for histologically confirmed oral cancer cases. Forty eight patients who were recently diagnosed with oral cancer were selected as cases. Two healthy controls were selected for each observed case and they were matched with age (+/- 5 years) gender and location. Use of different forms of tobacco such as cigarettes, pipe-smoking and shamma (smokeless-tobacco) was assessed. Khat, a commonly used chewing substance in the community was also included. Descriptive analysis was first performed followed by multiple logistic regression (with and without interaction) to derive odds ratios (ORs) and 95% confidence interval (CIs). Results: Mean age of the study sample (56% males and 44% females) was 65.3 years. Multinomial regression analysis revealed that shamma use increased the odds of developing oral cancer by 29 times (OR=29.3; 10.3-83.1). Cigarette (OR=6.74; 2.18-20.8) was also seen to have an effect. With the interaction model the odds ratio increased significantly for shamma users (OR=37.2; 12.3-113.2) and cigarette smokers (OR=10.5; 2.88-3.11). Khat was observed to have negative effect on the disease occurrence when used along with shamma (OR=0.01; 0.00 - 0.65). Conclusions: We conclude that shamma, a moist form of smokeless tobacco is a major threat for oral cancer occurrence in the Jazan region of Saudi Arabia. This study gives a direction to conduct further longitudinal studies in the region with increased sample size representing the population in order to provide more substantial evidence.

Software approach towards understanding meteorological data for environmental monitoring and assessment of peninsular Malaysia

Quadri, Sayed Abulhasan,Sidek, Othman,Jafar, Hadi,binti Amran, Nur Amira,bt Zabah, Ummi Nurulhaiza,bin Abdullah, Azizul Techno-Press 2014 Advances in environmental research Vol.3 No.1

The concern for the global environment ensues researchers from various disciplines to work in collaboration to tackle with the issues of sustainability and environmental conservation for well-being of the people. In this study, we have selected and focused on few basic environment-effecting factors such as temperature, humidity, carbon dioxide and oxygen concentration level and referred them as meteorological data. In this paper, we present the development of our own customized hardware setup, environmental monitoring device (EMD) to obtain the data. Utilizing the relationship among these basic parameters, represented in the form of formulas and equations, we tried to encode them using Matlab programming. Data visualization is achieved by plotting the graphs of basic parameters obtained from EMD as well for the derivatives using Matlab programs.

Regulation of Class II Bacteriocin Production by Cell-Cell Signaling

Quadri, Luis E.N. The Microbiological Society of Korea 2003 The journal of microbiology Vol.41 No.3

Production of ribosomally synthesized antimicrobial peptides usually referred to as bacteriocins is an inducible trait in several gram positive bacteria, particularly in those belonging to the group of lactic acid bacteria. In many of these organisms, production of bacteriocins is inducible and induction requires secretion and extracellular accumulation of peptides that act as chemical messengers and trigger bacteriocin production. These inducer peptides are often referred to as autoinducers and are believed to permit a quorum sensing-based regulation of bacteriocin production. Notably, the peptides acting as autoinducers are dedicated peptides with or without antimicrobial activity or the bacteriocins themselves. The autoinducer-dependent induction of bacteriocin production requires histidine protein kinases and response regulator proteins of two-component signal transduction systems. The current working model for the regulation of class II bacteriocin production in lactic acid bacteria and the most relevant direct and indirect pieces of evidence supporting the model are discussed in this minireview.

Effectiveness of an Intervention Program on Knowledge of Oral Cancer among the Youth of Jazan, Saudi Arabia

Quadri, Mir Faeq Ali,Saleh, Sanaa Mahmoud,Alsanosy, Rashad,Abdelwahab, Siddig Ibrahim,Tobaigy, Faisal Mohamed,Maryoud, Mohamed,Al-Hebshi, Nezar Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Background: The study is the first of its kind to be conducted in Saudi Arabia (KSA), aiming to analyze the effectiveness of an intervention program in improving the knowledge of oral cancer among the youth. Materials and Methods: A total of 1,051 young Saudis (57% males and 43% females with a mean age of $20.4{\pm}1.98$) were selected using multi-stage cluster sampling. Knowledge assessment was accomplished using a closed-ended questionnaire which was subjected to reliability tests. Prevalence of risk factors in relation to gender was analyzed using the chi-squared test. Effectiveness was calculated by comparing the pre- and post-intervention means, using the two-tailed paired t-test. Multiple logistic regression was employed in order to determine factors associated with awareness of risk habits, signs/symptoms and prevention of oral cancer. The significance level in this study was set at 0.05. Results: Females were seen to be more into the habit of sheesha smoking (3.3% rather than the use of other forms of risk factors. Prevalence of diverse risk factors such as cigarette smoking (20%), sheesha (15.3%), khat (27%) and shamma (9%) was seen among males. Gender and the use of modifiable risk factors among the study sample were significantly (p<0.001) associated with effectiveness of the intervention. The intervention program was highly effective (p<0.001) in improving the knowledge of oral cancer among the youth in Jazan, KSA. Multivariate analysis revealed that age and gender are the most significant factors affecting knowledge. Conclusions: The study gives a direction for further public health initiatives in this oral cancer prone region.

Zein 바이오폴리머가 토양 침식에 미치는 영향

쿼드리올라쿤레바바툰데 ( Quadri Olakunle Babatunde ),손동건 ( Dong Geon Son ),허윤검 ( Yoon Geom Heo ),변용훈 ( Yong-hoon Byun ) 한국농공학회 2022 한국농공학회 학술대회초록집 Vol.2022 No.-

Soil erosion has a significant influence on agricultural sustainability, resulting in critical economic, environmental and engineering challenges. This study presents the improvement of soil internal erosion using a novel zein biopolymer binder. In this study, cohesionless soils which are susceptible to erosion are considered as a specimen. A comparative test is conducted on untreated and treated soil specimens prepared using a 1 % mass of zein biopolymer binder. Specimens are compacted in an acrylic transparent mold with a 6 mm predrilled axial hole. Soil specimens are subjected to a hole erosion test at a constant hydraulic gradient and flow rate after curing for predetermined periods. The experimental results show that erosion occurs rapidly in an untreated specimen, resulting in total soil collapse. The application of zein biopolymer binder significantly improves the erosion resistance of the treated specimen. The erosion rate of the treated specimen decreases with increasing curing period. Based on the experimental result, zein biopolymer is suggested as a potential binder to mitigate soil erosion.

Geo-Congress 2023 참가수기

( Babatunde Quadri Olakunle ) 한국농공학회 2023 韓國農工學會誌 : 전원과 자원 Vol.65 No.3

A Novel Methodology for Auditing the Threats in Cloud Computing - A Perspective based on Cloud Storage

Nasreen Sultana Quadri,Kusum Yadav,Yogesh Kumar Sharma International Journal of Computer ScienceNetwork S 2024 International journal of computer science and netw Vol.24 No.2

Cloud computing is a technology for delivering information in which resources are retrieved from the internet through a web-based tools and applications, rather than a direct connection with the server. It is a new emerging computing based technology in which any individual or organization can remotely store or access the information. The structure of cloud computing allows to store and access various information as long as an electronic device has access to the web. Even though various merits are provided by the cloud from the cloud provides to cloud users, it suffers from various flaws in security. Due to these flaws, data integrity and confidentiality has become a challenging task for both the storage and retrieval process. This paper proposes a novel approach for data protection by an improved auditing based methodology in cloud computing especially in the process of cloud storage. The proposed methodology is proved to be more efficient in auditing the threats while storing data in the cloud computing architecture.