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Min Li,Minhui Huang,Zhiguo Zhang,Qiwei Yang,Yiwen Yang,Zongbi Bao,Qilong Ren 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.10
L-arabinose and D-galactose could be released during the hydrolysis process of Arabic gum. The development of a crystallization process of L-arabinose is highly dependent on the knowledge of the solubility of both saccharides. In this work, the solubility of L-arabinose and D-galactose in binary mixtures of methanol-water or ethanolwater (mole fraction of water 0.5816) was determined at temperatures between 278.15 and 333.15K by a static equilibrium method. The experimental data correlated well with the modified Apelblat equation, the simplified polynomial empirical equation, NRTL model and UNIQUAC model. Additionally, the thermodynamic properties including the dissolution enthalpy and entropy were obtained from the experimental data. Within the studied temperature range, the dissolution is endothermic and the dissolution process is non-spontaneous.
Qin Pan,Qilong Wang,Fengling Luo,Min Li,Xianru Xia Dongdong Shi,Xiao-Lian Zhang 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Tuberculosis (TB) has been a major world-wide cause of death for centuries. One-third of the world’s population is infected with Mycobacterium tuberculosis (M.tb), the etiologic agent of TB. The development of potent new anti-TB drugs is urgently needed. The major M.tb surface lipoglycans, mannose-capped Lipoarabinomannan (ManLAM) had immunosuppressive effects during M.tb infection. In this study, aptamer ZXL1 which specifically bound to ManLAM from the virulent strain M.tb H37Rv was screened out by Systematic Evolution of Ligands by EXponential enrichment (SELEX). The binding affinity of ZXL1 to ManLAM was measured as 8.907X10-8 M of quilibrium dissociation constant (Kd) value by surface plasmon resonance (SPR) analysis. We found that aptamer ZXL1 prevented the ManLAM-induced immunosuppressive effects on DCs and inhibited M. tb entry into macrophages. More importantly, we found that single injection of aptamer ZXL1 significantly prolonged the survival rate of infected mice, and prevent the infected rhesus monkeys from weight loss. The Bacterial numbers were significantly lower in the lungs and spleens in ZXL1-treated groups. These results suggest that aptamer ZXL1 can be used as antimycobacterial agent or as TB vaccine adjuvent.
Effects of different diets on the growth and development of young silkworms
Wang Yuanfei,Shu Qilong,Gu Haoyi,Feng Piao,Dai Minli,Zhu Qingyu,Liu Wei,Dai Yan,Li Fanchi,Li Bing 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4
To investigate the impact of different diets on the growth and development of the silkworm Bombyx mori (L.; Lepidoptera: Bombycidae), we conducted an analysis of differentially expressed genes (DEGs) between larvae fed an artificial diet (referred to as the AD group) and those fed mulberry leaves (referred to as the ML group) during the first, second, and third instars using RNA sequencing (RNA-Seq) technology. Our results revealed that the DEGs primarily belonged to pathways associated with lipid metabolism, carbohydrate metabolism, amino acid metabolism, the endocrine system, the nervous system, the digestive system, the immune system, and oxida tion–reduction processes. Notably, in the AD group, there was a decrease in transcript levels of genes related to amino acid metabolism synthases, while the transcript levels of antimicrobial peptide genes were up-regulated. Furthermore, genes associated with cytochrome P450 (CYP) enzymes exhibited down-regulation in the AD group. These observed changes likely contributed to the delayed growth and compromised robustness observed in the AD group. Overall, these findings provided valuable insights into the mechanisms underlying the differ ences in growth, development, disease resistance, and adversity resistance between silkworms fed an artificial diet and those fed mulberry leaves.
Enhanced Aerosol-Cloud Relationships in More Stable and Adiabatic Clouds
Yoo-Jun Kim,Byung-Gon Kim,Mark Miller,Qilong Min,Chang-Keun Song 한국기상학회 2012 Asia-Pacific Journal of Atmospheric Sciences Vol.48 No.3
Modification of cloud microphysics and cloud albedo by cloud-active aerosol is generally identified and accepted, but the nature and magnitude of aerosol-cloud interactions are vaguely understood and thought to include a myriad of processes that vary regionally and confound the application of simple physical models of cloud-aerosol sensitivity. This paper presents observations demonstrating that cloud top stability through its regulation of mixing and vertical development is one of the critical mechanisms that regulate cloud response to cloud-active aerosol in some cloud systems. Strong above-cloud inversions are shown to buffer marine stratocumulus from the effects of mixing with drier, warmer inversion air. This buffering reduces the variability of the cloud liquid water path (LWP) and enables the clouds to remain nearly adiabatic. While weaker above-cloud inversions in continental stratocumulus promote variability in the LWP and sub-adiabatic LWPs, stronger inversions in marine stratocumulus enables a relatively adiabatic existence that increases the relationship of cloud microphysical alteration to cloudactive aerosol. This study has important implications for Geoengineering in that it demonstrates that cloud systems overlain by strong thermal inversions are more likely to respond predictably to intentional manipulation of the in-cloud concentration of cloud-active aerosol.