http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
ROLLOVER SIMULATION OF SPORTS UTILITY VEHICLES
M. RAM PRABHU(M. RAM PRABHU),N.S. ANDRES(N.S. ANDRES),엄용균(Y.G. Eom),장봉춘(B.C. JANG) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.5_2
The simulations on dynamic stability of Sports Utility Vehicles using Carsim/Vehsim software are presented on this paper with the aim of studying the rollover process occurring in such vehicles. Carsim/Vehsim is an integrated simulation package that has been developed for chassis dynamics controls and integration. The simulation procedure makes use of dynamic testing maneuvers (Fishhook tests, J-Turn test and Double Lane Change test) recommended by NHTSA to evaluate the antirollover propensities of SUVs on road. The simulation results emphasize the need for better understanding of SUV rollover performance and characteristics that are very essential in enhancing vehicle design. Furthermore, the simulation dramatically shows less development time and cost reduction compared to field testing. This paper, in general, investigates the dynamic rollover characteristics of 4 SUVs in 2 different road conditions.
Prabhu, V. Vasan,Rajini, V.,Balaji, M.,Prabhu, V. The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.2
This paper's focus is in reducing the torque ripple and increasing the average torque by optimizing switching angles of 8/6 switched reluctance motor while implementing a robust speed controller in the outer loop. The mathematical model of the machine is developed and it is simulated using MATLAB/Simulink. An objective function and constraints are formulated and Optimum turn-on and turn-off angles are determined using Particle swarm optimization and Genetic Algorithm techniques. The novelty of this paper lies in implementing sliding mode speed controller with optimized angles. The results from both the optimization techniques are then compared with initial angles with one of them clearly being the better option. Speed response is compared with PID controller.
V. Vasan Prabhu,V. Rajini,M. Balaji,V. Prabhu 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.2
This paper’s focus is in reducing the torque ripple and increasing the average torque by optimizing switching angles of 8/6 switched reluctance motor while implementing a robust speed controller in the outer loop. The mathematical model of the machine is developed and it is simulated using MATLAB/Simulink. An objective function and constraints are formulated and Optimum turn-on and turn-off angles are determined using Particle swarm optimization and Genetic Algorithm techniques. The novelty of this paper lies in implementing sliding mode speed controller with optimized angles. The results from both the optimization techniques are then compared with initial angles with one of them clearly being the better option. Speed response is compared with PID controller.
Kisspeptins (KiSS-1): Essential Players in Suppressing Tumor Metastasis
Prabhu, Venugopal Vinod,Sakthivel, Kunnathur Murugesan,Guruvayoorappan, Chandrasekharan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Kisspeptins (KPs) encoded by the KiSS-1 gene are C-terminally amidated peptide products, including KP-10, KP-13, KP-14 and KP-54, which are endogenous agonists for the G-protein coupled receptor-54 (GPR54). Functional analyses have demonstrated fundamental roles of KiSS-1 in whole body homeostasis including sexual differentiation of brain, action on sex steroids and metabolic regulation of fertility essential for human puberty and maintenance of adult reproduction. In addition, intensive recent investigations have provided substantial evidence suggesting roles of Kisspeptin signalling via its receptor GPR54 in the suppression of metastasis with a variety of cancers. The present review highlights the latest studies regarding the role of Kisspeptins and the KiSS-1 gene in tumor progression and also suggests targeting the KiSS-1/GPR54 system may represent a novel therapeutic approach for cancers. Further investigations are essential to elucidate the complex pathways regulated by the Kisspeptins and how these pathways might be involved in the suppression of metastasis across a range of cancers.
Prabhu Srilakshmi,Bharadwaj Dhanya Y.,Bubbly S.G.,Gudennavar S.B. 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3
Over the last few years, lead-free inorganic metal perovskites have gained impressive ground in empowering satellites in space exploration owing to their material stability and performance evolution under extreme space environments. The present work has examined the versatility of eight such perovskites as space radiation shielding materials by computing their photon, charged particles and neutron interaction parameters. Photon interaction parameters were calculated for a wide energy range using PAGEX software. The ranges of heavy charged particles (H, He, C, N, O, Ne, Mg, Si and Fe ions) in these perovskites were estimated using SRIM software in the energy range 1 keVe10 GeV, and that of electrons was computed using ESTAR NIST software in the energy range 0.01 MeVe1 GeV. Further, the macroscopic fast neutron removal cross-sections were also calculated to estimate the neutron shielding efficiencies. The examined shielding parameters of the perovskites varied depending on the radiation type and energy. Among the selected perovskites, Cs2TiI6 and Ba2AgIO6 displayed superior photon attenuation properties. A 3.5 cm thick Ba2AgIO6-based shield could reduce the incident radiation intensity to half its initial value, a thickness even lesser than that of Pb-glass. Besides, CsSnBr3 and La0.8Ca0.2Ni0.5Ti0.5O3 displayed the highest and lowest range values, respectively, for all heavy charged particles. Ba2AgIO6 showed electron stopping power (on par with Kovar) better than that of other examined materials. Interestingly, La0.8Ca0.2Ni0.5Ti0.5O3 demonstrated neutron removal cross-section values greater than that of standard neutron shielding materials - aluminium and polyethylene. On the whole, the present study not only demonstrates the employment prospects of eco-friendly perovskites for shielding space radiations but also suggests future prospects for research in this direction
Prabhu, N.S.,Yun, H. Elsevier Science, Inc 2017 Journal of molecular graphics & modelling Vol.75 No.-
Photo-induced covalent crosslinking has emerged as the powerful strategy for analyzing and characterizing the protein-protein interaction and mapping protein 3D conformations. In the last decades, a number of photocrosslinking amino acids have been reported but only a few have been efficiently utilized for photocrosslinking purposes. Recently, incorporation of diazirine containing photoactivatable analogs such as photo-methionine, photo-leucine, photo-isoleucine and photo-lysine into target proteins were accomplished in live cells (Human A549cells, HEK 293) by depleting corresponding natural amino acid and supplementing these analogs in the medium. Likewise, incorporation of photo-methionine and photo-leucine is also reported in E. coli. Incorporation of these unnatural amino acids were demonstrated only in a limited number species, thereby conventional methods have been utilized for the protein-protein interaction study in other species. With this in mind, we studied in silico analysis of polyspecificity of four endogenous tRNA synthetases (LeuRS, IleRS, MetRS, and LysRS) from six different species such as Escherichia coli, Pseudomonas fluorescens, Corynebacterium glutamicum, Saccharomyces cerevisiae, Aspergillus oryzae and Homo sapiens towards its photocrosslinking amino acids. In addition, here we describe the active site similarity of different protein bio-factories. Based on the active site similarity and similar binding mode, we predicted that the endogenous tRNA synthetases of all the species are reactive to corresponding photoactivatable analogs. This is the first in silico study to demonstrate that the photocrosslinking unnatural amino acids are recognized by the endogenous tRNA synthetases of different protein expression biofactories.
Targeting Tumor Metastasis by Regulating Nm23 Gene Expression
Prabhu, V. Vinod,Siddikuzzaman, Siddikuzzaman,Grace, V.M. Berlin,Guruvayoorappan, C. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
The Nm23 gene is a metastatic suppressor identified in a melanoma cell line and expressed in different tumors where their levels of expression are associated with reduced or increased metastatic potential. Nm23 is one of the over 20 metastasis suppressor genes (MSGs) confirmed in vivo. It is highly conserved from yeast to human, implying a critical developmental function. Tumors with alteration of the p53 gene and reduced expression of the Nm23 gene are more prone to metastasis. Nm23-H1 has 3'-5' exonuclease activity. This review focuses on the role of Nm23 in cancer progression and also a potential novel target for cancer therapy.
Pre-loading enhancement of compressive residual stress at crack-tip in acoustic cavitation
Prabhu Murugesan,정성환,이형일 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.3
We propose to combine the crack tip stress field with acoustic cavitation to generate compressive residual stress at the crack tip in the bulk metal which is challenging to access. The sharply increasing stress profile (stress singularity) at the crack tip offers to amplify plastic deformation induced by the local impacts (shockwave/microjet) from the acoustic cavitation introduced to the crack tip, which then enhances the compressive residual stress generation at the crack tip. The effect of the crack tip stress field on compressive residual stress generation was experimentally investigated for crack depths of 10 and 20 mm. The experiments prove that the crack tip stress field increases the acoustic cavitation-based compressive residual stress by up to three times. Also, the stress intensity factor of the crack tip stress field was found suitable to represent the engagement of the crack tip stress field with the cavitationbased compressive residual generation.