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- 검색키워드
- 저자 : Perez-Alvarez, Marissa (검색결과 18 건)
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( Marta Perez De Lis Novo ),( Roberto Perez Alvarez ),( Soledad Retamozo ),( Pilar Brito Zeron ),( Xavier Bosch ),( Antoni Siso Almirall ),( Jaume Villalta ),( Ricardo Alvarez Vijande ),( Alfonso Lope 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyse the possible existence of features associated with IgG4-related disease (IgG4-RD) in patients diagnosed with retroperitoneal fi brosis or mesenteritis. Methods: Study cohort including patients diagnosed with retroperitoneal fi brosis and/ or mesenteritis by imaging studies (CT) in a university hospital during the last 20 years. Results: A total of 22 patients diagnosed with retroperitoneal fi brosis (15 patients) or mesenteritis (7 patients) are described (6 women and 16 men, with a mean age at diagnosis of 64.1 years, range: 46-82. The main clinical manifestations present at diagnosis were abdominal/back pain (n=14), general malaise/fever (n=7) and the presence of edema/thrombosis (n = 6); in one patient, diagnosis was made incidentally by imaging techniques. CT showed infl ammatory masses affecting retroperitoneal (n=17), mesenteric (n=7) and vascular structures, including iliac arteries (n=3), aorta (n=2), renal arteries (n=2) and cava (n=2). In 7 (32%) patients, involvement of other organs suggestive of IgG4-RD (liver/bile tract in 2 cases, periaortitis in 2 cases, pleura, lymph nodes and skin in 1 each, respectively) was found. Diagnosis was confi rmed by biopsy in 8 patients (36%); in any patient, studies to rule out IgG4-RD were performed. The main treatments included corticosteroids (n=17), immunosuppressive agents (azathioprine in 5, methotrexate in 1 and mycophenolate in 1), surgery (n = 5) and the placement of urinary catheters (n = 4). After a mean follow-up of 73 months, 7 patients died (32%) patients (4 of them due to septic shock). Conclusions: Ormond`s disease is a rare clinical entity but associated with a signifi cant morbidity and mortality. His recent inclusion in the clinical spectrum of IgG4-RD diffi cult their retrospective diagnosis, although this study and others recently published suggest that about half of the cases could correspond to IgG4-RD.
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( Marta Perez De Lis Novo ),( Alexandre Perez Gonzalez ),( Melania Estevez Gil ),( Emma Filgueira Davila ),( Julian Fernandez Martin ),( Roberto Perez Alvarez ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyse the epidemiological, clinical, diagnostic and therapeutic features related to the development of spondylodiscitis in a cohort of Spanish patients. Methods: A retrospective analysis of 75 cases of infectious spondylodiscitis diagnosed in university hospital between 2000 and 2013. Results: We studied 75 patients with a mean age of 63 + / - 20 years, of which 67% were male. Time average evolution of disease prior to consultation was 4.2 months. The main symptom was back pain or back pain (90%) The most frequent location was the lumbar spondylodiscitis (74%), 60% of patients had one or more associated diseases (Diabetes:20%; COPD: 18%; tumors: 17%). Furthermore, 50% of them suffered from heart disease, being the most frequently hypertensive. 23% of patients carried immunosuppressive therapy, mainly corticosteroids (90%). In 53 patients (70%) could be performed a certain diagnosis, with Staphylococcus aureus the most frequent (41%) followed by S. epidermidis (17%), and Streptococcus (15%). Blood cultures were positive in 60% of cases and surgical biopsy was performed in 37% of the patients. 8 cases had endocarditis criteria, 6 of which were fulfi lled by S. aureus. MRI was performed in 75% cases, being in all cases, pathological. The average length of treatment was 12 weeks, with the most commonly used antibiotics cloxacillin, vancomycin and ceftriaxone. 18% of patients underwent surgery, performed laminectomy and drainage of abscesses. During evolution 6 patients died. 10 patients (8%) had sequelae neurological. Conclusions: Spondylodiscitis is a rare disease in adults, but with high morbidity and mortality due to the diffi culty of diagnosis. Insidious development and the lack of specifi city of the symptoms it interferes with the diagnosis and treatment early, so a high index of suspicion is essential.
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The Effect of Ginseng on Muscle Injury and Inflammation
Alvarez, A.I.,De Oliveira, A.C. Cabral,Perez, A.C.,Vila, L.,Ferrando, A.,Prieto, J.G. The Korean Society of Ginseng 2004 Journal of Ginseng Research Vol.28 No.1
The effect of Panax ginseng administration in muscle inflammatory process induced after eccentric exercise, that causes myofibrillar disruption, was studied. Changes in lipid peroxidation, inflammation, glycogen levels in muscle and release of myocellular proteins to blood were measured. The analyses were performed immediately after eccentric exercise and over week since this period are necessary for the muscle damage-repair cycle. The ginseng extract (100 mg kg$^{-1}$ ) was orally administered to rats for three months, before the eccentric exercise performance. The results showed the protective role of ginseng against skeletal muscle damage. This effect could be associated with their membrane stabilising capacity since creatine kinase (CK) activity was significantly decreased 96 h post-exercise from 523$\pm$70 to 381$\pm$53 and 120 h post-exercise from 443$\pm$85 to 327$\pm$75 in treated animals. $\beta$-glucuronidase activity, as indicator of inflammation, showed a significant reduction of about 15-25% in soleus, vastus and triceps in these post-exercise times. The lipid peroxidation, measured by malondyaldehyde levels, was significantly decreased in the 24 h post-exercise period in soleus and vastus intermedius muscles and on the recovery period. Finally ginseng administration reduced significantly the decrease of the glycogen levels immediately after exercise and when the regenerative process took place (72-168 h post exercise). Collectively, the results have showed that ginseng did not inhibit the vital inflammatory response process associated with the muscle damage-repair cycle but presumably ameliorate the injury.
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An Approach to Art Collections Management and Content-based Recovery
( Concepcion Perez De Celis Herrero ),( Jaime Lara Alvarez ),( Gustavo Cossio Aguilar ),( Maria J. Somodevilla Garcia ) 한국정보처리학회 2011 Journal of information processing systems Vol.7 No.3
This study presents a comprehensive solution to the collection management, which is based on the model for Cultural Objects (CCO). The developed system manages and spreads the collections that are safeguarded in museums and galleries more easily by using IT. In particular, we present our approach for a non-structured search and recovery of the objects based on the annotation of artwork images. In this methodology, we have introduced a faceted search used as a framework for multi-classification and for exploring/browsing complex information bases in a guided, yet unconstrained way, through a visual interface.
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The Effect of Ginseng on Muscle Injury and Inflammation
A.I. Alvarez,A.C. Cabral de Oliveira,A.C. Perez,L.Vila,A. Ferrando,J.G. Prieto 고려인삼학회 2004 Journal of Ginseng Research Vol.28 No.1
The effect of Panax ginseng administration in muscle inflammatory process induced after eccentric exercise, that causes myotibrillar disruption, was studied. Changes in lipid peroxidation, inflammation, glycogen levels in muscle and release of myocellular proteins to blood were measured. The analyses were performed immediately after eccentric exercise and over week since this period are necessary for the muscle damage-repair cycle. The ginseng extract (100 mg·kg^(-1)) was orally administered to rats for three months, before the eccentric exercise performance. The results showed the protective role of ginseng against skeletal muscle damage. This effect could be associated with their membrane stabilising capacity since creatine kinase (CK) activity was significantly decreased 96 h post-exercise from 523±70 to 381±53 and 120 h post-exercise from 443±85 to 327±75 in treated animals. β-glucuronidase activity, as indicator of inflammation, showed a significant reduction of about 15-25% in soleus, vastus and triceps in these post-exercise times. The lipid peroxidation, measured by malondyaldehyde levels, was significantly decreased in the 24 h post-exercise period in soleus and vastus intermedius muscles and on the recovery period. Finally ginseng administration reduced significantly the decrease of the glycogen levels immediately after exercise and when the regenerative process took place (72-168 h post exercise). Collectively, the results have showed that ginseng did not inhibit the vital inflammatory response process associated with the muscle damage-repair cycle but presumably ameliorate the injury.
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( Pilar Brito Zeron ),( Marta Perez De Lis Novo ),( Roberto Perez Alvarez ),( Jacobo Sellares ),( Soledad Retamozo ),( Xavier Bosch ),( Fernanda Hernandez ),( Josep Manel Santos ),( Antoni Siso Almira 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyse the infi uence of the epidemiological profi le in the disease expression of a large series of patients with sarcoidosis. Methods: Study cohort including 160 patients diagnosed with sarcoidosis in the last 10 years. The diagnosis of sarcoidosis was based on clinical criteria and imaging studies, together with the histopathological demonstration of non-necrotizing granulomas, and excluding other granulomatous diseases, mainly infectious (tuberculosis). Results: There were 106 women and 54 men, with a mean age at diagnosis of 46.87 years. The main clinical manifestations present at diagnosis were respiratory symptoms (40%), followed by general symptoms (31%), skin lesions (29%) and the incidental fi nding of imaging fi ndings in asymptomatic patients (18%). 37% of patients had adisease onset <40 years. This early onset of disease was reported mainly in males (44% vs 28%, p=0.027) and was associated with a higher frequency of general symptoms (42% vs 25%, p=0.023), erythema nodosum (29% vs 16%, p=0.041), uveitis (14% vs. 5%, p=0.05) and joint involvement (17% vs 5%, p=0.014), but with a lower frequency of interstitial lung disease (25% vs 42%, p=0.028) and splenic involvement (0% vs 7%, p=0.037). With respect to the differential presentation of the disease according to gender, women diagnosed with sarcoidosis had a higher mean age at diagnosis (48.8 vs 42.8 years, p=0.017), a higher frequency of skin involvement (35% vs 13%, p=0.003) and a lower frequency of pulmonary (34% vs 52%, p=0.022), hepatosplenic (2% vs 9%, p=0.044) and nervous system (3% vs 13%, p=0.032) involvements in comparison with males. Conclusions: An early disease onset (<40 years) was mainly associated with general and cutaneous involvement, while sarcoidosis in men affects more frequently vital organs.
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( Pilar BRITO ZERÓN ),( Marta PEREZ DE LIS NOVO ),( Roberto PÉREZ ALVAREZ ),( Pedro MORAL MORAL ),( Aleida MARTÍNEZ ZAPICO ),( Guadalupe FRAILE ),( Eva FONSECA ),( María VAQUERO HERRERO ),( Angela RUI 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyze the therapeutic management and the main epidemiological and clinical characteristics related to survival in a large series of patients with hemophagocytic syndrome (HS) diagnosed in Departments of Internal Medicine. Methods: In June 2013, the Study Group of Autoimmune Diseases (GEAS-SEMI) creates a national registry of patients with HS. Patients were diagnosed according to the fulfillment of the criteria of the Histiocytosis Society in 1991 and updated in 2004. Results: At June 15, 2014, the REGHEM registry included 88 patients with HS, 35 (40%) men and 55 (60%) women, with a mean age at diagnosis of 49.16 years (range 12- 84 years). During the admission that led to the diagnosis of SH, acute infections were identified in 50 (57%) patients, including viruses (n=20), bacteria (n=13), mycobacteria (n=8) and parasites/fungi (n=13). Patients were treated with corticosteroids (n=40), etoposide (n=12), cyclosporin A (n=12), methotrexate (n=4), tacrolimus (n=2) rituximab (n=3), intravenous immunoglobulins (n=2) and chemotherapy (n=5). A total of 44 (50%) patients died. The main factors associated with mortality were analytical parameters at diagnosis such as the presence of severe anemia (Hb <9 g/L, 89% vs 66%, p=0.01), platelet count <100,000/mm3 (96% vs 64%, p<0.001), neutropenia <1000/mm3 (59% vs 39%, p=0.044), and bacterial infections as precipitating agent (77% vs 45%, p=0.034); a clinical presentation including lymphadenopathy was associated with a lower mortality (59% vs 39%, p=0.044). Conclusions: Hemophagocytic syndrome is a severe multisystemic disease associated in nearly 50% of cases with an acute infection, and usually requires vital support in intensive care units. Despite this and the use of a complex therapeutic approach, half of the patients died. The main prognostic factor identified is the presence at diagnosis of severe cytopenias and the coexistence of bacterial infections.
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( Pilar Brito Zeron ),( Marta Perez De Lis Novo ),( Soledad Retamozo ),( Lluisa Alos ),( Albert Bove ),( Hoda Gheitasi ),( Belchin Kostov ),( Antoni Siso Almirall ),( Roberto Perez Alvarez ),( Manuel 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyze the safety and utility of minor lip biopsy by using the minimally invasive technique, performed in the Department of internal medicine, in patients presenting with immunonegative sicca syndrome. Methods: Prospective analysis of 122 patients (100 women, mean age 60 years) with sicca syndrome and negative anti-Ro/La antibodies in which minimally invasive biopsy of minor salivary glands was performed. Results: The most common histopathological feature consisted of lymphoplasmacytic infi ltration in 57 (47%) patients, followed by fi brosis in 46 (38%) and acinar atrophy in 32 (26%); the type of lymphoplasmacytic infi ltrate was detailed in 53 patients (21 lymphocytic, 20 plasmacytic, and 12 lymphoplasmacytic). According to the lymphocytic classifi cation of Chisholm and Mason, 53 (44%) were classifi ed as normal, 42 (35%) grade I, 11 (9%) grade II, 8 (7%) grade III and 7 (6 %) grade IV. Histopathologic diagnosis were: normal in 46 patients, non-specifi c sialadenitis in 42, primary Sjogren`s syndrome in 26 (15 as the fi nal diagnosis, 11 and probable), and other diagnoses in 6 (fat infi ltration in 5, systemic amyloidosis in 1); no cases of infi ltration by granulomas or IgG4+ were found. The presence of fi brosis was detected more frequently in women (43% vs 14%, p=0.014); the existence of fi brosis (67.70 vs 55.76 years) and acinar atrophy (69.50 vs 56.71 years) correlated with increasing age. No correlation between the degree of infi ltration and diagnostic or immunological features was found. Only 8% patients reported transient adverse events. Conclusions: In 21% of patients with an immunonegative sicca syndrome, a diagnosis of primary SS was confi rmed by minimally invasive biopsy, whereas 35% of patients disclosed a non-specifi c chronic sialadenitis, which could refl ect a “mild” SS that have no place in the current classifi cation criteria of this disease.
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An Approach to Art Collections Management and Content-based Recovery
De Celis Herrero, Concepcion Perez,Alvarez, Jaime Lara,Aguilar, Gustavo Cossio,Garcia, Maria Josefa Somodevilla Korea Information Processing Society 2011 Journal of information processing systems Vol.7 No.3
This study presents a comprehensive solution to the collection management, which is based on the model for Cultural Objects (CCO). The developed system manages and spreads the collections that are safeguarded in museums and galleries more easily by using IT. In particular, we present our approach for a non-structured search and recovery of the objects based on the annotation of artwork images. In this methodology, we have introduced a faceted search used as a framework for multi-classification and for exploring/browsing complex information bases in a guided, yet unconstrained way, through a visual interface.
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de Sanjose, Silvia,Mbisa, Georgina,Perez-Alvarez, Susana,Benavente, Yolanda,Sukvirach, Sukhon,Hieu, Nguyen Trong,Shin, Hai-Rim,Anh, Pham Thi Hoang,Thomas, Jaiyeola,Lazcano, Eduardo,Matos, Elena,Herrer University of Chicago Press 2009 The Journal of infectious diseases Vol.199 No.10
<P>BACKGROUND: The aim of the present study was to estimate the prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in the female general population, to define geographic variation in and heterosexual transmission of the virus. METHODS: The study included 10,963 women from 9 countries for whom information on sociodemographic characteristics and reproductive, sexual, and smoking behaviors were available. Antibodies against KSHV that encoded lytic antigen K8.1 and latent antigen ORF73 were determined. RESULTS: The range of prevalence of KSHV (defined as detection of any antigen) was 3.81%-46.02%, with significant geographic variation noted. In Nigeria, the prevalence was 46.02%; in Colombia, 13.32%; in Costa Rica, 9.81%; in Argentina, 6.40%; in Ho Chi Minh City, Vietnam, 15.50%; in Hanoi, Vietnam, 11.26%; in Songkla, Thailand, 10%; in Lampang, Thailand, 8.63%; in Korea, 4.93%; and in Spain, 3.65%. The prevalence of KSHV slightly increased with increasing age among subjects in geographic areas where the prevalence of KSHV was high, such as Nigeria and Colombia, and it significantly decreased with increases in the educational level attained by subjects in those areas. KSHV was not statistically associated with age at first sexual intercourse, number of sex partners, number of children, patterns of oral contraceptive use, presence of cervical human papillomavirus DNA, or smoking status. CONCLUSIONS: The study provides comparable estimates of KSHV prevalence in diverse cultural settings across 4 continents and provides evidence that sexual transmission of KSHV is not a major source of infection in the general population.</P>
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