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Drug Target Prediction Using Elementary Mode Analysis in Ascaris lumbricoides Energy Metabolism
K. Parvatham,L. Veerakumari 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.3
Ascariasis, an intestinal worm infection is caused by the parasite Ascaris lumbricoides and a report by World Health Organization (WHO) on soil transmitted helminths suggests that over one billion people are affected by Ascariasis. This disease is prevalent in developing countries, and in places of poor sanitation and unhygienic conditions. Even though anthelminthic drugs are available for the treatment of ascariasis, it is considered as a neglected tropical disease (NTD). Resistance of the parasite to the existing drugs necessitates a detailed study of its energy metabolism for identification of new drug targets. The catabolic pathway of the parasite is an evolved design well suited for parasitic life and obtains constant input from its host. Its energy metabolism is predominantly anaerobic. The parasite mitochondrion plays a key role as it lacks the functional tricarboxylic acid cycle (TCA cycle) and cytochrome oxidase activity. In adult ascarid mitochondrion,there is no external final electron acceptor and endogenously produced fumarate and 2-methyl branched- chain enoyl –CoAs function as the terminal electron acceptors instead of oxygen. In this study, elementary flux mode analysis (EFM),a metabolic pathway analysis tool has been applied to model energy metabolism of the parasite A. lumbricoides. This study identifies a set of enzymes that have been suggested to be essential for the survival of the parasite;the inhibition of these enzymes paralyzes the parasite. The key enzymes of glycolysis and the phosphoenolpyruvate carboxykinase-succinate pathway are identified as drug targets since the knock-out of any of these enzymes results in zero flux value for all EFM that have been identified.
On Uniformly Starlike Functions of Order (α,β)
R. Parvatham ...et al KYUNGPOOK UNIVERSITY 1996 Kyungpook mathematical journal Vol.36 No.1
Certain properties regarding integral operator, convolution, neighbourhood are studied for the class SP(α,β) of uniformly starlike functions of order (α,β) and UCV (α,β) of uniformly convex functions of order (α,β).
Effect of Aflatoxin on Feed Conversion Ratio in Broilers: A Meta-analysis
Suganthi, R. Umaya,Suresh, K.P.,Parvatham, R. Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.12
Aflatoxins are natural contaminants of poultry feeds and feed ingredients and cause liver damage, immunosuppression, reduction in performance and mortality in broilers. A number of studies have been carried out to study the effects of aflatoxin on feed conversion ratio in broilers. The results on feed conversion ratio of 10 research articles in broilers fed with aflatoxin from first day of age to six weeks of age were compiled and were subjected to meta-analysis. Chi-square test and $Tau^2$ (heterogeneity co-efficient) were applied to test for significance of heterogeneity of studies. To integrate results, fixed effect model by Inverse Variance method (IV method) was used when heterogeneity was insignificant and otherwise random effect model by DerSimonian and Laird Method (DL method) was used. The results of meta-analysis showed that the adverse effect of aflatoxin on feed conversion ratio at the end of first week was negligible, second week was medium and third to six weeks was very large.