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G. Suresh,M. R. Ramesh,M. S. Srinath 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8
This paper reports on a study of the high-temperature tribological performance of self-lubricating nickel-based compositeclad. A porous and crack free clad containing matrix, reinforcement, and lubricant phase is developed on titanium 31 alloyusing microwave irradiation. The microstructure of both NiCrSiB/WC and NiCrSiB/WC/Ag/BaF2 clad revealed very goodmetallurgical bonding with the substrate. The average microhardness of NiCrSiB/WC and NiCrSiB/WC/Ag/BaF2 clad is710.58 HV and 650.25 HV respectively, is comparatively higher than the titanium 31 substrate (320 HV). The addition of Agand BaF2solid lubricants in the clad endowing clad to operate at a broad temperature range. Compared with the NiCrSiB/WCclad, solid lubricant encapsulate clad has shown very low friction coefficient and wear rates. The sliding wear characteristicsof the clad were investigated by varying load and temperatures. The results revealed that oxide phases (NiO and Cr3O)andlubricant phases (Ag and BaWO4)formed at low and high temperatures are adequate to reduce delamination and material loss.
Medical student’s perception to different types of set induction in anatomy lectures
Suresh Narayanan,Suresh Narayanan,Nachiket Shankar,Vimala Ananthy 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.3
Set induction refers to the process of using a thought-provoking statement, interesting fact, or an audio-visual stimulus at the beginning of lecture to gain student’s attention and give an overview about the lecture topic. In the present study, students were introduced to three types of set induction namely narratives, food-based analogies and humor-based images or activities at the beginning of anatomy lecture and their response to it is collected and analyzed. The objective of the study is to estimate the difference in a questionnaire-based perception score between the three different types of set induction; estimate sex differences in the questionnaire-based perception score. Students rated the validated, 7-item perception questionnaire using a 5-point Likert scale. Students felt that food-based analogies and humor-based images were more interesting, motivated them to participate in lecture-discussion than the narrative set induction. The familiarity of set induction varied between all the three different types of set induction. There was no significant difference in the perception of different types of set induction between male and female undergraduate students. Based on the student’s feedback, it could also serve as a memory aid and ease the students learning experience. Majority of students responded positively to the use of set induction and recommended for its use in future classes.
The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming
Suresh, Bharathi,Lee, Junwon,Kim, Kye-Seong,Ramakrishna, Suresh Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-
<P>Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell maintenance and differentiation. There are two switches: an E3 ubiquitin ligase enzyme that tags ubiquitin molecules to the target proteins for proteolysis and a second enzyme, the deubiquitinating enzyme (DUBs), that performs the opposite action, thereby preventing proteolysis. In order to maintain stemness and to allow for efficient differentiation, both ubiquitination and deubiquitination molecular switches must operate properly in a balanced manner. In this review, we have summarized the importance of the ubiquitination of core stem cell transcription factors, such as Oct3/4, c-Myc, Sox2, Klf4, Nanog, and LIN28, during cellular reprogramming. Furthermore, we emphasize the role of DUBs in regulating core stem cell transcriptional factors and their function in stem cell maintenance and differentiation. We also discuss the possibility of using DUBs, along with core transcription factors, to efficiently generate induced pluripotent stem cells. Our review provides a relatively new understanding regarding the importance of ubiquitination/deubiquitination of stem cell transcription factors for efficient cellular reprogramming.</P>
Kinetic Analysis of the MAPK and PI3K/Akt Signaling Pathways
Suresh Babu, CV,Babar, Sheikh Md. Enayetul,Song, Eun Joo,Oh, Eulsik,Yoo, Young Sook Korean Society for Molecular Biology 2008 Molecules and cells Vol.25 No.3
Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently.
A JITTER FREE ALL DIGITAL PHASE LOCKED LOOP
Suresh,Maya,Mourad,Samiha 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1
A digital Phase Locked Loop (PLL) is easier to implement, has good dynamic range, initializes quickly and has higher noise immunity compared to an analog PLL However, a digital PLL usually has high jitter. This paper describes the design of a fitter free digital PLL that has been prototyped in an ACTEL FPGA. The digital PLL consists of a phase detector, a loop filter and a digital controlled oscillator. The phase detector produces an output proportional to the phase difference between the output clock and the incoming clock The output of the loop filter counter is compared to that of the digital controlled oscillator (DCO) The DCO produces the output signal which is aligned to the incoming frequency signal. The frequency range is 0.25 MHz to 15 MHz and the lock frequency range is ± 20 KHz
Suresh, K.,PoornachandraRao, Nannapaneni V.,Murthy, K.V.R. Techno-Press 2014 Advances in materials research Vol.3 No.4
$Ce^{4+}$, $Eu^{3+}$, $Tb^{3+}$ co-doped $Ca_3Si_3O_8F_2$ phosphor was synthesized via solid state reaction method using $CaF_2$, $CaCO_3$ and $SiO_2$ as raw materials for the host and $Eu_2O_3$, $CeO_2$, and $Tb_4O_7$ as activators. The luminescent properties of the phosphor was analysed by spectrofluorophotometer at room temperature. The effect of excitation wavelengths on the luminescent properties of the phosphor i.e. under near-ultraviolet (nUV) and visible excitations was investigated. The emission peaks of $Ce^{4+}$, $Eu^{3+}$, $Tb^{3+}$ co-doped $Ca_3Si_3O_8F_2$ phosphor lays at 480(blue band), 550(green band) and 611nm (red band) under 380nm excitation wavelength, attributed to the $Ce^{4+}$ ion, $Tb^{3+}$ ion and $Eu^{3+}$ ions respectively. The results reveal that the phosphor emits white light upon nUV (380nm) / visible (465nm) illumination, and a red light upon 395nm / 535nm illumination. RE ions doped $Ca_3Si_3O_8F_2$ is a promising white light phosphor for LEDs. The emission colours can be seen using Commission international de l'eclairage (CIE) co-ordinates. A single host phosphor emitting different colours under different excitations indicates that it is a potential phosphor having applications in many fields.