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Park, Youngil,Kim, Beomjin,Lee, Ki-Ho,Lee, Ji-Hoon,Oh, Se-Young,Park, Jongwook American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.5
<P>DPBP-EPY has the same structure with DPBP-EIF, one of blue-light-emitting materials, except their cores, in which the former has two imine groups, but the latter has only carbon-containing groups. The electro-optical properties modulated by the adoption of the different core structures were systematically examined. It was confirmed that the maximum values in the UV-visible and PL spectra of DPBP-EPY were about 19-46 nm red-shifted from those of DPBP-EIF due to the electron-withdrawing effect of the imine groups whether in solution or in solid. In addition, in case of DPBP-EPY where imine group is substituted, LUMO level of DPBP-EPY decreased while HOME level did not show any significant change. Furthermore, the results of the non-doped OLED device built with these two materials for an emitting layer indicated that DPBP-EPY needed about 2 V lower operation-voltage, and produced higher quantum yield than DPBP-EIF. In particular, it was shown that DPBP-EPY emitted purer and deeper blue-light with CIE coordinate (0.157,0.131) than DPBP-EIF with CIE coordinate is (0.179, 0.191).</P>
Park, Youngil,Lee, Ji-Hoon,Jung, Dong Hyun,Liu, Su-Hao,Lin, You-Heng,Chen, Li-Yin,Wu, Chung-Chih,Park, Jongwook Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.28
<P>This study not only describes the synthesis and characterization of a novel indenofluorene derivative, 6,6,12,12-tetraethyl-2,8-bis-[1,1′;3′,1′]terphenyl-4′-yl-6,12-dihydro-indeno[1,2-b]fluorine (TP-EIF), for use as an emitting material in blue organic light emitting diodes (OLEDs), but also the comparison with 6,6,12,12-tetraethyl-2,8-bis-[1,1′;3′,1′]terphenyl-4′-yl-6,12-dihydro-diindeno[1,2-b;1′,2′-e]pyrazine (TP-EPY). UV-visible and PL spectra showed that the TP-EPY absorption and emission bands were red-shifted with narrow full widths at half maxima (FWHMs) compared to TP-EIF, both in solution and as a film. Density functional theory electronic structure calculations suggested that the spectral differences arose from the electron withdrawing properties of the imine group in the indenopyrazine, which increased conjugation in the core group and decreased conjugation in the side group at the LUMO level. The lower energy of the LUMO in TP-EPY resulted in increased active electron injection in electron-only devices and cyclic voltammetry (CV) measurements. The hole mobilities, which were measured by time of flight (TOF) methods, were 1.8 × 10<SUP>−3</SUP> and 1.1 × 10<SUP>−4</SUP> cm<SUP>2</SUP> V<SUP>−1</SUP> s for TP-EPY and TP-EIF, respectively, which demonstrated that TP-EPY displayed excellent hole transport abilities. The electron mobility was also high in TP-EPY (8.3 × 10<SUP>−5</SUP> cm<SUP>2</SUP> V<SUP>−1</SUP> s). TP-EPY was, therefore, shown to be bipolar, unlike TP-EIF. The electroluminescence (EL) performance of TP-EPY in OLED devices was higher than that of TP-EIF: the luminance efficiencies were 1.72 and 0.76 cd A<SUP>−1</SUP>, and the power efficiencies were 0.65 and 0.27 lm W<SUP>−1</SUP>, for TP-EPY and TP-EIF, respectively. In particular, the FWHMs of the EL spectral bands were 54 nm for TP-EPY and 73 nm for TP-EIF, which demonstrated enhanced emission spectral purity. The external quantum efficiency of TP-EPY was 5.1%, which was more than twice the value for TP-EIF (2.19%).</P> <P>Graphic Abstract</P><P>A new indenofluorene derivative, TP-EIF was synthesized, and its physical properties (optical, thermal, electrochemical, electroluminescent, and charge carrier mobility characteristics) were compared with those of the previously described TP-EPY, which has an imine group in the core structure. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0jm00581a'> </P>
A case of congenital melanocytic nevus with halo phenomenon accompanied by vitiligo
( Youngil Kim ),( Hyunjung Kwon ),( Hyungrok Kim ),( Inyong Kim ),( Kyungduck Park ),( Joonsoo Park ),( Hyun Chung ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Halo nevus is a round to oval shaped hypopigmented patch around a pigmented nevus. Only 4.7% of halo nevus is being reported around congenital nevus and much rarer with vitiligo. The pathogenesis of congenital halo nevus and vitiligo is still unclear, but considering that the CD 8 positive T lymphocyte infiltrate around the melanocyte and autoantibody to melanocyte is found in both diseases, same autoimmune process may participate in both diseases.A 6-year-old boy presented with whitish depigmentation around a brownish pigmented patch on right neck. The brownish pigmented patch appeared since birth and the depigmented lesion appreared 3 years ago. Since then hypopigmented patches were occurred at both periocular area and knee area. Koebner phenomenon was also observed. Histologically, nevus cells and inflammatory cell infiltration was observed at the brownish pigmented area. On the other hand, at depigmented area, there was significant decrease in melanocyte melanin in epidermis and dermis. The patient was diagnosed with congenitaal melanocytic nevus with halo phenomenon accompanied by vitiligo and excision was planned but the patient was transferred to other dermatologic clinic. Herein, we describe a 6-year-old boy with congenital melanocytic nevus with halo phenomenon accompanied by vitiligo.
Park, Wan Beom,Cho, Joo-Youn,Park, Sang-In,Kim, Eun Jung,Yoon, Seonghae,Yoon, Seo Hyun,Lee, Jeong-Ok,Koh, Youngil,Song, Kyoung-Ho,Choe, Pyoeng Gyun,Yu, Kyung-Sang,Kim, Eu suk,Bang, Su Mi,Kim, Nam Joon Elsevier 2016 INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS Vol.48 No.1
<P><B>Abstract</B></P> <P>Few data are available on whether adjusting the dose of posaconazole syrup is effective in patients receiving anti-cancer chemotherapy. The aim of this prospective study was to analyse the impact of increasing the frequency of posaconazole administration on optimal plasma concentrations in adult patients with haematological malignancy. A total of 133 adult patients receiving chemotherapy for acute myeloid leukaemia or myelodysplastic syndrome who received posaconazole syrup 200 mg three times daily for fungal prophylaxis were enrolled in this study. Drug trough levels were measured by liquid chromatography–tandem mass spectrometry. In 20.2% of patients (23/114) the steady-state concentration of posaconazole was suboptimal (<500 ng/mL) on Day 8. In these patients, the frequency of posaconazole administration was increased to 200 mg four times daily. On Day 15, the median posaconazole concentration was significantly increased from 368 ng/mL [interquartile range (IQR), 247–403 ng/mL] to 548 ng/mL (IQR, 424–887 ng/mL) (<I>P</I> = 0.0003). The median increase in posaconazole concentration was 251 ng/mL (IQR, 93–517 ng/mL). Among the patients with initially suboptimal levels, 79% achieved the optimal level unless the steady-state level was <200 ng/mL. This study shows that increasing the administration frequency of posaconazole syrup is effective for achieving optimal levels in patients with haematological malignancy undergoing chemotherapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Increasing the frequency of posaconazole syrup is effective for adjusting drug levels. </LI> <LI> Optimal drug levels are not achieved when steady-state level is <200 ng/mL. </LI> <LI> In only 5.3% (6/114), drug levels remained suboptimal despite dose adjustment. </LI> </UL> </P>
Park, Hyunkyung,Lee, Yoo Jin,Shin, Sang-Jin,Lee, Jayoun,Park, Silvia,Kim, Inho,Moon, Joon-ho,Lee, Hyewon,Jang, Jun Ho,Yoon, Sung-Soo,Koh, Youngil Elsevier 2018 Leukemia research Vol.69 No.-
<P><B>Abstract</B></P> <P>A substantial proportion of patients requiring allogeneic stem cell transplantation (alloSCT) do not have a human leukocyte antigen-matched sibling donor and need an alternative donor. In this multicenter retrospective study, we compared the outcomes of 176 patients with myelodysplastic syndrome and acute leukemia undergoing alloSCT from haploidentical (<I>n</I> = 121) and international (<I>n</I> = 55) donors between 2002 and 2016. For recipients of haploidentical and international donors, the 2-year overall survival rates were 33.4% and 35.3%, respectively (<I>P</I> = 0.347), and relapse-free survival rates were 31.7% and 34.4% (<I>P</I> = 0.264), respectively. In addition, there were no significant differences in the cumulative incidences of acute and chronic graft versus host disease or incidences of infection within 30 days (all <I>P ></I> 0.05). Similarly, there were no significant differences in these measures for acute leukemia patients (<I>n</I> = 143; all <I>P ></I> 0.05). A multivariate analysis revealed that the donor type was not an independent prognostic or predictive factor. These data suggest that both haploidentical and international donors are feasible alternative sources for alloSCT when a matched donor is not available domestically.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Haploidentical and international donor recipients have similar survival rates. </LI> <LI> Transplant-related complications occur similarly with both donor types. </LI> <LI> Both donor types are alternatives if a matched donor is not available domestically. </LI> </UL> </P>
A study on multi-cultural family wives adapting to Korean cuisine and dietary patterns
Youngil Park,Hee Sun Jeong,Nami Joo 한국영양학회 2010 Nutrition Research and Practice Vol.4 No.5
With the increase in multi-cultural families, Korea is seeing a rapid increase in immigrated housewives, who are closely related to food culture. However, studies for the diet of multi-cultural families, which is most closely related to our lives have not been sufficiently researched. With this background, this study conducted research for immigrated women nationwide about food cultures to provide the possibility which Korean food culture would be developed harmoniously with various foreign food cultures. In this study, the immigrated women seemed to have adapted to Korean food culture quickly, but they showed differences according to some conditions like countries they are from and the time they have been in Korea. To achieve this, we need to conduct consistent and in depth studies for food cultures in multi-cultural families so that we can make healthy development in food culture, harmonious with traditional Korean culture.
Park, Jihye,Park, Eonjeong,Kim, Aejin,Lee, Youngil,Chi, Ki-Whan,Kwak, Jong Hwan,Jung, Young Hoon,Kim, In Su American Chemical Society 2011 ORGANIC LETTERS Vol.13 No.16
<P>A rhodium-catalyzed oxidative acylation of benzamides with aryl aldehydes via direct sp<SUP>2</SUP> C–H bond cleavage is described. In the presence of [Cp*RhCl<SUB>2</SUB>]<SUB>2</SUB>, AgSbF<SUB>6</SUB>, and silver carbonate as an oxidant, <I>N</I>,<I>N</I>-diethyl benzamides can be effectively carbonylated to yield <I>ortho</I>-acyl benzamides.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2011/orlef7.2011.13.issue-16/ol201729w/production/images/medium/ol-2011-01729w_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol201729w'>ACS Electronic Supporting Info</A></P>