Application of Testing-Tracing-Treatment Strategy in Response to the COVID-19 Outbreak in Seoul, Korea

Park Yoojin,Huh In Sil,Lee Jaekyung,Kang Cho Ryok,조성일,Ham Hyon Jeen,Kim Hea Sook,Kim Jung-il,나백주,Lee Jin Yong,Seoul Metropolitan Government COVID-19 Rapid Response (SCoRR) Team 대한의학회 2020 Journal of Korean medical science Vol.35 No.45

Background: Following the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, a total of 637 patients had been diagnosed with the disease in Seoul as of May 2, 2020. Our study aimed to describe the impact of the 3T strategies (preemptive testing, prompt tracing and proper treatment) on the epidemiological characteristics of COVID-19 in Seoul. Methods: The descriptive and explanatory analysis was carried out on critical indicators such as epidemiological characteristics and key duration of patient status change from January 24 to May 2 in Seoul before and after preemptive testing for patients under investigation associated with COVID-19 clusters. Results: Preemptive testing increased the positive test rate (3.9% to 4.2%), an asymptomatic case at diagnosis (16.9% to 30.6%), and reduced the time from symptom onset to quarantine (4.0 to 3.0 days). Prompt tracing decreased unknown sources of infection (6.9% to 2.8%), the mean number of contacts (32.2 to 23.6), and the time-varying reproduction number R(t) (1.3 to 0.6). With proper treatment, only 2 cases of mortality occurred, resulting in a fatality rate of just 0.3%. Conclusion: In the first wave of the COVID-19 pandemic lasting 100 days, the effect of the 3T strategies flattened the curve and decreased the time during which infected individuals were contagious, thereby lowering the R(t) below 1 in Seoul.

NonO binds to the CpG island of oct4 promoter and functions as a transcriptional activator of oct4 gene expression

Park, Yoojin,Lee, Ja-Myong,Hwang, Min-Young,Son, Gi-hoon,Geum, Dongho Springer-Verlag 2013 Molecules and cells Vol.35 No.1

Outbreak of carbapenem-resistant Enterobacterales at a long-term care facility in Seoul, Korea: surveillance and intervention mitigation strategies

Yoojin Park,Euncheol Son,Young June Choe,Cho Ryok Kang,Sangmi Roh,Young Ok Hwang,Sung-il Cho,Jihwan Bang 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Because effective decolonization options are not available, and treatment options are limited, carbapenem-resistant Enterobacterales (CRE) constitute increasingly threatening nosocomial pathogens. To prevent CRE-associated transmission and ensure patient safety, healthcare personnel and everyone in contact with CRE-infected patients must implement stringent infection control practices. This report describes a CRE outbreak, possibly related to a caregiver at a long-term care facility (LTCF), and presents a new surveillance model to improve the infection control of CRE in Seoul, Korea. METHODS: The Seoul Metropolitan Government surveillance system identified an outbreak of CRE in an LTCF in 2022. We obtained data on the demographic characteristics and contact histories of the inpatients, medical staff, and caregivers. To isolate the inpatients and employees exposed to CRE, we used rectal swab samples and environmental sampling during the study period (May-December 2022). RESULTS: We identified 18 cluster cases (1 caregiver and 17 inpatients) and 12 sporadic cases with CRE, and conducted a complete 197-day follow-up of all cases in the LTCF’s isolation wards. CONCLUSIONS: This investigation demonstrated that our surveillance model and targeted intervention, based on the cooperation of the municipal government, public health center, and infection control advisory committee, effectively contained the epidemic at the LTCF. Measures to improve the compliance of all employees in LTCFs with infection control guidelines should also be adopted.

Misinterpretation of a skin fold artifact as pneumothorax on the chest x-ray of a trauma patient in Korea: a case report

Yoojin Park,Eun Young Kim,Byungchul Yu,Kunwoo Kim The Korean Society of Traumatology 2024 大韓外傷學會誌 Vol.37 No.1

Misinterpreting radiographic findings can lead to unnecessary interventions and potential patient harm. The urgency required when responding to the compromised health of trauma patients can increase the likelihood of misinterpreting chest x-rays in critical situations. We present the case report of a trauma patient whose skin fold artifacts were mistaken for pneumothorax on a follow-up chest x-ray, resulting in unnecessary chest tube insertion. We hope to help others differentiate between skin folds and pneumothorax on the chest x-rays of trauma patients by considering factors such as location, shape, sharpness, and vascular markings.

Facile conversion of ATP-binding RNA aptamer to quencher-free molecular aptamer beacon

Park, Yoojin,Nim-anussornkul, Duangrat,Vilaivan, Tirayut,Morii, Takashi,Kim, Byeang Hyean Pergamon Press 2018 Bioorganic & medicinal chemistry letters Vol.28 No.2

<P><B>Abstract</B></P> <P>We have developed RNA-based quencher-free molecular aptamer beacons (RNA-based QF-MABs) for the detection of ATP, taking advantage of the conformational changes associated with ATP binding to the ATP-binding RNA aptamer. The RNA aptamer, with its well-defined structure, was readily converted to the fluorescence sensors by incorporating a fluorophore into the loop region of the hairpin structure. These RNA-based QF-MABs exhibited fluorescence signals in the presence of ATP relative to their low background signals in the absence of ATP. The fluorescence emission intensity increased upon formation of a RNA-based QF-MAB·ATP complex.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

G-Quadruplex formation using fluorescent oligonucleotides as a detection method for discriminating AGG trinucleotide repeats

Park, Yoojin,Kim, Ki Tae,Kim, Byeang Hyean The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.86

<P>We have developed a simple and sensitive system for detecting AGG trinucleotide repeats through the formation of intermolecular G-quadruplexes using a fluorescent oligonucleotide. The fluorescence signal increased rapidly and dramatically by 44.7-fold with respect to the low background signal in the presence of RNA agg repeats and by 35.0-fold in the presence of DNA AGG repeats.</P>

바운딩 박스 이미지 라벨링을 위한 크라우드소싱 게임 설계

박유진(Yoojin Park),정현준(Hyunjun Jung),이석훈(Sukhoon Lee) 한국정보기술학회 2023 Proceedings of KIIT Conference Vol.2023 No.6

승강식피난기의 성능기술기준 개선방안 연구

박유진(YooJin Park),최규출(KyuChool Choi) 한국화재소방학회 2022 한국화재소방학회 학술대회 논문집 Vol.2022 No.춘계

대도시 중심의 생활공간 확대로 초고층 건축물이 일반화되었다. 건축물이 거대해지고 복잡해짐에 따라 화재와 같은 재난 시 긴급 피난이 더 중요해진 것이다. 대형 건물 화재 시 인명피해는 대부분 연기로 인해 발생한다. 화재 현장을 빨리 벗어나야 하는 이유이다. 계단이 막혀 피난이 어려운 긴급 상황에서 쉽게 탈출하는 시설이 피난 기구이다. 피난 기구는 화재 현장에서 마지막으로 사용하는 비상 탈출수단이다. 현재 소방시설법은 11층 이상에는 피난 기구 설치를 제외하고 있다. 이는 고층에서 안전하게 사용할 수 있는 피난 기구가 없기 때문이다. 최근 기술의 발달로 고층에서도 얼마든지 사용 가능한 피난기구가 개발되었다. 국가화재안전기준에도 이러한 피난 기구 설치기준을 제시하고 있다. 하지만 11층 이상에는 법적인 예외규정에 따라 설치하지 않기 때문에 무용지물이다. 본 연구에서는 소방청 고시로 운영되고 있는 승강식피난기의 성능인증 기술기준을 분석하였다. 승강식피난기가 성능인증 기술기준의 개선으로 고층건축물에 사용할 수 있는지 연구하였다. 관계 기관에서는 고층에서 안전하게 사용할 수 있는 피난 기구가 없어서 11층 이상의 피난 기구 설치 제외조항을 바꿀 수 없다는 논리이기 때문이다. 현 기술기준이 규정하고 있는 기준 외에 몇 가지 기준을 추가하면 고층건축물에도 사용할 수 있다는 결론을 얻었다. 새로운 기술이 개발되면서 관련 기준도 개정되어 현장에 개발품이 설치되어야 관련 산업도 발전하고, 국민안전도 실현될 것이다.

크라우드소싱 기반의 이미지 라벨링 게임 구현

박유진(Yoojin Park),원도연(Doyeon Won),이승연(Seungyeon Lee),이석훈(Sukhoon Lee) 한국정보기술학회 2023 Proceedings of KIIT Conference Vol.2023 No.11

전국 발달장애성인의 삶의 질 수준과 배경변인에 따른 삶의 질 수준의 차이 분석

박승희 ( Park Seung Hee ),김유진 ( Kim Yoojin ),이성아 ( Lee Seong Ah ),정지희 ( Jeong Jeehee ) 한국지적장애교육학회(구 한국정신지체아교육학회) 2020 지적장애연구 Vol.22 No.4

본 연구의 목적은 전국 발달장애성인의 삶의 질 수준을 파악하기 위하여 신뢰롭고 타당한 삶의 질 척도를 사용하여 발달장애성인의 삶의 질의 전체 및 하위요인 수준을 제시하고 발달장애성인의 배경변인에 따른 삶의 질 수준의 차이 분석과 그 시사점을 제시하는 것이다. 전국 5개 권역별 발달장애인 인구비율에 따라 층화표집을 시도하여 실제 회수된 자료를 통해 총 407명 발달장애성인의 삶의 질을 측정하고 분석하였다. 연구도구는 2019년에 새롭게 개발 및 타당화된 “한국 발달장애성인의 삶의 질 척도”(QLS-KADD, 박승희 외, 2019)를 사용하였다. 이 척도는 삶의 질 전체 점수와 4가지 하위요인 및 32개 문항 점수를 산출한다. 연구결과 발달장애성인의 삶의 질 전체 평균은 5점 척도에서 3.32로 보통 수준으로 긍정적 수준에는 못 미쳤다. 4개 하위요인 점수도 3점대 보통 수준인데, 안전한 환경, 사회적 참여지원, 신체적 안녕, 개인적 역량 순으로 높게 나와서 개인적 역량의 수준이 가장 낮았다. 발달장애성인의 배경변인 총 14개 중 11가지에서(예: 장애정도, 거주환경, 고용형태, 친구 수, 직업 외 참여 프로그램 수 등) 하위집단별로 삶의 질에 유의한 차이를 나타냈다. 본 연구는 전국에서 표집된 발달장애성인 407명에 대해 처음으로 신뢰롭고 타당한 삶의 질 척도를 사용하여 삶의 질의 수준을 측정 및 배경변인별 차이를 분석한 결과와 그 시사점을 제공한다. 이 결과는 국내 발달장애성인의 삶의 질 수준의 현재 상황을 점검하고 삶의 질 향상을 위해 성인기 발달장애인을 위한 각종 서비스와 교육 및 지원 체계의 우선순위를 결정하고, 기존 프로그램을 개선하고 새로운 프로그램의 창안에 유용한 기초 자료를 제공하는 의의가 있다. The purpose of this study is to find out the overall and four-factor levels of quality of life of adults with developmental disabilities(DD) in Korea, and the differences in the quality of life among the subgroups according to their background variables. A total of 407 adults with DD drawn from 5 different geographical regions of Korea were measured by proxy reports and analyzed. The Quality of Life Scale for Korean Adults with DD(QLS-KADD)(Park et al., 2019) was employed to measure the quality of life. The scale consists of 32 items that yields the overall score as well as the scores for the four factors. It was found that the overall average level of quality of life of the adults with DD was 3.32 on a 5 point scale, which was not a positive level. Also, the scores of the 4 factors were in the 3-point range, and the results, ranked in descending order, were as follows: ‘secure environment’, ‘supports for social participation’, ‘physical wellbeing’, and ‘personal competency’. There were significant differences in the quality of life of subgroups according to the eleven background variables including disability severity, residential environment, employment type, number of friends, number of participating programs(apart from their jobs), etc. The findings and implications of the current status of the quality of life of 407 adults with DD measured with QLS-KADD were discussed. This study is significant in that it first examined the level of quality of life of Korean adults with DD nationwide and provided basic data for establishing the support system to enhance the quality of life of adults with DD, and suggested directions and priorities for improving the services and support systems for adults with DD.