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( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12
C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]
Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6
<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>
Park, Sang Uk,Zun, Chan Yong,Park, Doh-Young,Lim, Jaewon,Mok, Hyung Soo The Korean Society for Railway 2016 International Journal of Railway Vol.9 No.2
In this paper, a study on the efficiency improvement of the magnetic levitation train using the LIM (Linear Induction Motor) was presented. The maglev train has the advantage of being environmentally friendly since much less noise and dust is produced. However, due to structural limitation, compared to a rotating induction motor, linear induction motor, the main propulsion engine of the maglev train has a relatively greater air gap and hence has the lower operation efficiency. In this paper, the relationship between the operating condition of the train and the slip frequency has been investigated to find out the optimum slip frequency that might improve the efficiency of the magnetic levitation train with linear induction motor. The slip frequency is variable during the operation by this relationship only within a range that does not affect the levitation system of the train. After that, the comparison of the efficiency between the conventional control method with the slip frequency fixed at 13.5[Hz] and the proposed method with the slip frequency variable from 9.5[Hz] to 6.5[Hz] has been conducted by simulation using Simplorer. Experiments of 19.5[ton] magnetic levitation trains owned by Korea Institute of Machinery and Materials were carried out to verify the simulation results.
Optical Reactivity of Epitaxially Grown Nitrogen-Doped Titanium Oxide (TiO2) Films
Jaewon Park,Gyuchol Yi,Jun-Hyung Cho 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.5I
We investigated the optical-response properties of nitrogen(N)-doped titanium dioxide (TiO2) film by using a ultraviolet-visible absorption spectra. The TiO2 films were epitaxially grown on the sapphire substrate by using pulsed laser deposition (PLD) with and without oxygen gas introduction into the deposition chamber. The doping of N atoms was done by using 70-keV of N+ ion implantation, followed by post-irradiation heat treatment at 550 C for 2 hrs. Our experiment shows not only that N-ion doping causes the absorption edge of the epitaxially grown TiO2 film to be quite reproducibly shifted to lower energy by about 0.07 (0.09) eV when 5 × 1016(1 × 1017) N ions/cm2 are implanted, but also that a significant optical absorption extends into the visible-light region. The redshift of the oxygen deficient TiO2 film prepared in the absence of oxygen was about 0.23 eV, and N ion implantation into this under-stoichiometric film at 70 keV and an ion dose of 1 × 1017 ions/cm2 resulted in an additional band-edge shift.
Jaewon Park,Jun-Hyung Cho 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.4
Polymeric, metallic and ceramic materials were implanted by ions with energies less than 100 keV and current densities of 1015 . 1018 ions/cm2. Single or mixed ions of N, He, and C were implanted into the Polyethylene Terephtalate (PET). Mixed ion implantation caused greater surface hardness up to 3 times than that for single ion implantation. The surface electrical conductivity increases, along with the hardness increase, when the higher ion energy and ion dose were used, but the conductivity showed no relationship to the ion energy at lower ion energies (50keV). Ion implantation with 70 keV N ions of >5 × 1016/cm2 into stainless steel resulted in a hardness that was at least 2 times higher than non-irradiated specimen, and X-ray photoelectron spectroscopy (XPS) analysis showed the implanted N ions formed mostly Cr2N without post irradiation annealing. The light absorption edge of the epitaxially grown TiO2 film shifted to lower energy by about 0.07 (0.09) eV when 5 × 1016 (1 × 1017) N ions/cm2 were implanted, and a significant optical absorption extended into the visible region. Our band-structure calculations for N-doped TiO2 show that the bands originating from N2p states are located above the valence band edge, and that the band gap narrowing due to the mixing of N with O2p states is 0.04 eV.
The effect of personalized bowel preparation using the smartphone camera application: A pilot study
( Jaewon Jung ),( Jongha Park ),( Seunghyun Park ),( Ju Won Lee ),( Jonghwa Park ),( Gi Jung Jeon ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Background: Despite several attempts to improve the bowel preparation quality, they were not enough improved patients’ satisfaction and compliance during bowel preparation for colonoscopy. We aimed to investigate the effectiveness of the smartphone application which analyze and judge the optimal dosage of polyethylene glycol (PEG) for bowel preparation. Design: This prospective randomized controlled trial was investigator-blinded. Patients were assigned to usethe smartphone camera application (app group, n=30) for bowel preparation or just received the written instructions (non-app group, n=30). The app group used the smartphone camera application which was programmed to judge the bowel preparation quality automatically from the bowel preparation status. Application let them stop taking more PEG solution if their bowel preparation was appropriate as “pass or fail”. In contrast the non-app group took 4 liters of PEG solution as the provided manual. Results: The primary outcome was the quality of bowel preparation based on blinded ratings by the Ottawa bowel preparation scale (OBPS). The secondary outcomes were the difference of dosage of PEG between two groups and the acceptability of the camera application in the app group. The primary outcome showed no statistically significant difference of OBPS total score between the two groups (mean OBPS 2.53 ±1.264 vs. 2.79 ± 2.064, p=0.950). The secondary outcomes revealed that the app group took lower dose of PEG than non-app group (mean dosage (mL): 3713.16 ± 405.81 vs. 3979.17 ±102.06, p=0.001). The acceptability of the camera application showed good response in the app group (5-point Likert scale; 1=not acceptable, 5=very acceptable; mean score 4.37± 0.895, p<0.001). Conclusions: Although taking lower dose PEG, the bowel preparation using the smartphone camera application showed the similar quality of bowel preparation compared to conventional preparation group. Moreover, personalized bowel preparation using the smartphone camera application enhanced compliance of bowel preparation and patients’ satisfaction.