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Polymeric nano-shielded islets with heparin-polyethylene glycol in a non-human primate model
Park, Hyojun,Haque, Muhammad R.,Park, Jae Berm,Lee, Kyo Won,Lee, Sanghoon,Kwon, Yeongbeen,Lee, Han Sin,Kim, Geun-Soo,Shin, Du Yeon,Jin, Sang-Man,Kim, Jae Hyeon,Kang, Hee Jung,Byun, Youngro,Kim, Sung J Elsevier 2018 Biomaterials Vol.171 No.-
<P><B>Abstract</B></P> <P>Intraportal pancreatic islet transplantation incurs huge cell losses during its early stages due to instant blood-mediated inflammatory reactions (IBMIRs), which may also drive regulation of the adaptive immune system. Therefore, a method that evades IBMIR will improve clinical islet transplantation. We used a layer-by-layer approach to shield non-human primate (NHP) islets with polyethylene glycol (nano-shielded islets, NSIs) and polyethylene glycol plus heparin (heparin nano-shielded islets; HNSIs). Islets ranging from 10,000 to 20,000 IEQ/kg body weight were transplanted into 19 cynomolgus monkeys (n = 4, control; n = 5, NSI; and n = 10, HNSI). The mean C-peptide positive graft survival times were 68.5, 64 and 108 days for the control, NSI and HNSI groups, respectively (<I>P</I> = 0.012). HNSI also reduced the factors responsible for IBMIR <I>in vitro</I>. Based on these data, HNSIs in conjunction with clinically established immunosuppressive drug regimens will result in superior outcomes compared to those achieved with the current protocol for clinical islet transplantation.</P>
Chromosomal Information of 1,144 Korean BAC Clones
Park, Mi-Hyun,Lee, Hee-Jung,Kim, Kwang-Joong,Jeon, Jae-Pil,Lee, Hye-Ja,Kim, Jun-Woo,Kim, Hung-Tae,Cha, Hyo-Soung,Kim, Cheol-Hwan,Choi, Kang-Yell,Park, Chan,Oh, Berm-Seok,Kim, Ku-Chan Korea Genome Organization 2006 Genomics & informatics Vol.4 No.4
We sequenced 1,841 BAC clones by terminal sequencing, and 1,830 of these clones were characterized with regard to their human chromosomal location and gene content using Korean BAC library constructed at the Korean Science (KCGS). Sequence analyses of the 1,830 BAC clones was performed for chromosomal assignment: 1,144 clones were assigned to a single chromosome, 190 clones apparently assigned to more than one chromosome, and 496 clones to no chromosome. Evaluating gene content of the 1,144 BAC clones, we found that 706 clones represented 1,069 genes of which 415 genes existed in the BAC clones covering the full sequence of the gene, 180 genes covering a $50%{\sim}99%$, and 474 genes covering less than 50% of the gene coverage. The estimated covering size of the KBAC clones was 73,379 kilobases (kb), in total corresponding to 2.3% of haploid human genome sequence. The identified BAC clones will be a public genomic resource for mapped clones for diagnostic and functional studies by Korean scientists and investigators worldwide.