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- 저자 : Pakdel, Firouz Ghaderi (검색결과 5 건)
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Karimi Marzieh,Pakdel Mohammad Hossein,Bali lashaki Khosro,Soorni Aboozar 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.4
Cucumber is a commercially important vegetable crop whose growth and productivity are significantly influenced by salinity. Currently, there is little information about salt-related genes and the associated biological pathways involved in salt stress response and tolerance in this crop. Accordingly, this study aimed to unravel the complex molecular mechanism components underlying salinity in cucumber using long non-coding RNA (lncRNA) identification and weighted gene co-expression network analysis (WGCNA). Here, two previously published high-throughput RNA-seq datasets obtained from control and salt-treated tissues of cucumber roots and leaves were employed. First, the potential lncRNAs were identified based on a bioinformatics pipeline. Subsequently, differentially expressed genes (DEGs) and differentially expressed lncRNAs (DE-lncRNAs) were utilized as the input for the WGCNA to identify the clusters of highly interconnected lncRNAs and mRNAs. According to the results, 17 DE-lncRNAs out of 279 and 7 DE-lncRNAs out of 166 putative lncRNAs were detected between salt-treated and control samples in root and leaf tissues, respectively. Using WGCNA, 2226 unique DEGs and 23 DE-lncRNAs were categorized into 10 distinctive co-expression modules, of which, four modules, including blue, brown, yellow, and turquoise, contained the highest number of salt-related genes. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis identified four significantly enriched pathways, including, “plant hormone signal transduction”, “starch and sucrose metabolism”, “MAPK signaling pathway”, and “phenylpropanoid biosynthesis”, related to salt stress response in cucumber. The novel hub genes identified in this study could be exploited for further functional studies aiming to introduce salt-tolerant cucumber varieties utilizing molecular engineering approaches.
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Acute Systemic Infusion of Bupropion Decrease Formalin Induced Pain Behavior in Rat
Naderi, Somayyeh,Pakdel, Firouz Ghaderi,Osalou, Mostafa Ashrafi,Cankurt, Ulker The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.2
Background: The chronic pain can disturb physical, psychological, and social performances. Analgesic agents are widely used but some antidepressants (ADs) showed analgesia also. Bupropion is using for smoke cessation but it can change morphine withdrawal signs such as pain. This study tested the acute systemic effect of bupropion on formalin induced pain behavior in rats. Methods: Wistar male healthy rats were divided into 7 groups (control, sham, and 5 treated groups with 10, 30, 90, 120, and 200 mg/kg of bupropion, i.p.). The bupropion injected 3 hours prior to formalin induced pain behavior. Formalin (50 ${\mu}l$, 2.5%) was injected subcutaneously in dorsal region of right hindpaw in all animals. Nociceptive signs were observed continuously on-line and off-line each minute. Common pain scoring was used for pain assessment. Results: The analysis of data by one-way ANOVA showed that bupropion can reduce pain scores in the second phase but not in first phase. Bupropion decreased the licking/biting duration significantly in first and second phase of formalin test. Conclusions: The results showed that bupropion has analgesic effects at systemic application. The change of second phase of the pain behavior was significant and it revealed that central mechanisms involve in bupropion analgesia.
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Acute Systemic Infusion of Bupropion Decrease Formalin Induced Pain Behavior in Rat
( Somayyeh Naderi ),( Firouz Ghaderi Pakdel ),( Mostafa Ashrafi Osalou ),( Ulker Cankurt ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.2
The chronic pain can disturb physical, psychological, and social performances. Analgesic agents are widely used but some antidepressants (ADs) showed analgesia also. Bupropion is using for smoke cessation but it can change morphine withdrawal signs such as pain. This study tested the acute systemic effect of bupropion on formalin induced pain behavior in rats.Methods: Wistar male healthy rats were divided into 7 groups (control, sham, and 5 treated groups with 10, 30, 90, 120, and 200 mg/kg of bupropion, i.p.). The bupropion injected 3 hours prior to formalin induced pain behavior. Formalin (50 μl, 2.5%) was injected subcutaneously in dorsal region of right hindpaw in all animals. Nociceptive signs were observed continuously on-line and off-line each minute. Common pain scoring was used for pain assessment. Results: The analysis of data by one-way ANOVA showed that bupropion can reduce pain scores in the second phase but not in first phase. Bupropion decreased the licking/biting duration significantly in first and second phase of formalin test. Conclusions: The results showed that bupropion has analgesic effects at systemic application. The change of second phase of the pain behavior was significant and it revealed that central mechanisms involve in bupropion analgesia. (Korean J Pain 2014; 27: 118-124)
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Azadeh Izadyari Aghmiuni,Saeed Heidari Keshel,Mostafa Rezaei-Tavirani,Farshid Sefat,Arash Khojasteh,Masoud Soleimani,Farzad Pakdel 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
Tissue engineering provides new approaches to improve skin lesions. However, cell differentiation onto theengineered substrate with the skin-like pattern is the main challenge. Here we have tried to fabricate such the substrate viastudying the change in polymers ratios and molecular weight, and grafting scaffold with silk fibroin (SF) biomaterial. To thisend, chitosan and PEG were mixed at the volume ratios of 25:75, 50:50, and 65:35, and samples were lyophilized by thefreeze-drying method. Based on the result, the ratio of 65:35 indicated better physicomechanical properties than two otherscaffolds. Afterward, Chi/PEG scaffolds were prepared via mixing chitosan/PEG with (65:35) and PEG molecular weights of2000, 4000, 6000, 10000 Da. It was found that the increase of PEG molecular weight (>4000) was led to the reduction intensile strength and elongation of the scaffold network. Hence, PEG4000 was selected as the optimum molecular weight todesign SF-grafted Chi/PEG scaffold. Therefore, Chi/PEG4000-SF scaffold was designed to evaluate the volume ratio of SF(1 %, 3 %, 5 %) and compare data with the decellularized dermis. The results showed Chi/PEG4000-SF(3%) scaffold not onlywas led to the same elongation as Chi/PEG-SF(5%) scaffold but also created the dermis-like modulus. Moreover, Chi/PEGSF(3%) provided higher expression level of keratinocytes (bio-mimetic pattern) than decellularized dermis due to betterphysicomechanical properties. Hence, it seems that engineered scaffolds can be a more suitable option than native tissue (dueto removal of limitations such as donor sites and immunogenicity, and their mechanical properties). This study can providenovel insight into the better design of skin-engineered scaffolds.
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