http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Siveen, K S,Nguyen, A H,Lee, J H,Li, F,Singh, S S,Kumar, A P,Low, G,Jha, S,Tergaonkar, V,Ahn, K S,Sethi, G Nature Publishing Group 2014 The British journal of cancer Vol.111 No.7
<P><B>Background:</B></P><P>Constitutive activation of signal transducer and activator of transcription signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide variety of malignancies including hepatocellular carcinoma (HCC).</P><P><B>Methods:</B></P><P>We evaluated the effect of lupeol on STAT3 signalling cascade and its regulated functional responses in HCC cells.</P><P><B>Results:</B></P><P>Lupeol suppressed constitutive activation of STAT3 phosphorylation at tyrosine 705 residue effectively in a dose- and time-dependent manner. The phosphorylation of Janus-activated kinases (JAKs) 1 and 2 and Src was also suppressed by lupeol. Pervanadate treatment reversed the downregulation of phospho-STAT3 induced by lupeol, thereby indicating the involvement of a phosphatase. Indeed, we observed that treatment with lupeol increased the protein and mRNA levels of SHP-2, and silencing of SHP-2 abolished the inhibitory effects of lupeol on STAT3 activation. Treatment with lupeol also downregulated the expression of diverse STAT3-regulated genes and decreased the binding of STAT3 to VEGF promoter. Moreover, the proliferation of various HCC cells was significantly suppressed by lupeol, being associated with substantial induction of apoptosis. Depletion of SHP-2 reversed the observed antiproliferative and pro-apoptotic effects of lupeol.</P><P><B>Conclusions:</B></P><P>Lupeol exhibited its potential anticancer effects in HCC through the downregulation of STAT3-induced pro-survival signalling cascade.</P>
P.P. Sahay,R.K. Mishra,S.N. Pandey,S. Jha,M. Shamsuddin 한국물리학회 2013 Current Applied Physics Vol.13 No.3
Zn-doped SnO2 nanoparticles were prepared by the chemical co-precipitation route. X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses of these prepared nanoparticles were carried out for structural and morphological studies. All the samples have been found to have tetragonal rutile structure of the polycrystalline SnO2 having crystallite size in the range 13e25 nm. TEM micrographs show agglomeration of nanoparticles in all the samples. At a particular temperature, the dielectric constant of all the samples has been found to decrease with increasing frequencies which may be due to rapid polarization processes occurring in SnO2 nanoparticles. The ac conductivity, s (u), has been found to vary with frequency according to the relation s (u) f uS. The value of S has been found to be temperature dependent, decreasing with increasing frequency which suggests that a hopping process is the most likely conduction mechanism in these nanoparticles. The room temperature photoluminescence (PL) spectra of the undoped and Zn-doped SnO2 nanoparticles consist of the near bandedge ultraviolet (UV) emission and the defect related visible emissions. The origin of emission peaks in the visible region is attributed to oxygen-related defects that are introduced during growth.
Synchronization and Operation of Parallel Inverters using Droop Control
L. K. Sahoo,N. D. Thakur,K. Rai,P Sensarma,R. D. Jha,P. Mohanty,A Sharma 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
To obtain a continuous power supply Distributed Generation (DG) with a Decentralized Power System (DPS), i.e. replacing a single UPS unit with multiple, smaller units in parallel, is emerging as new paradigm. The technically challenging aspect of DPS is the synchronization of inverters and load sharing among the parallel connected inverters. In this paper, a control method is proposed and implemented for synchronization and parallel operation of inverters. Droop control method has been used for equal power sharing, and design of power control loop. The design issues for voltage control loop are analyzed with the discussion of relative stability of the system. A current control loop is designed and analyzed to provide synchronization between the inverters.
H. K. Narang,M. M. Mahapatra,P. K. Jha,PVSS Sridhar,P. Biswas 대한용접·접합학회 2018 대한용접·접합학회지 Vol.36 No.2
Weld reinforcements play vital role in controlling different formation of inherent strains in the heat-affected zone in arc welded joints. It is desirable to have adequate weld reinforcements on both the top and bottom sides of butt joint such that shrinkage force effects of both the reinforcements would be cancelling the angular distortion. In this study, it has been established by experiments that acceptable top and bottom weld reinforcements can be achieved and angular distortion can be controlled in square butt joints through submerged arc welding (SAW) done from both the sides with accurate control of welding process parameters. Such process does not require use of costly backing strip and instead a flux bed can be used for the purpose. Modeling of the process was also carried out using 3-D thermomechanical finite element (FE) analysis. Moving distributed heat source, weld reinforcements on top and bottom side, weld deposition in each welding pass and temperature dependent thermos-physical properties were used in the thermomechanical analysis for predicting the temperature profiles and angular distortion patterns The numerically predicted temperature distribution and distortion patterns indicated close agreement with the experimentally observed results.
Ramakar Jha,K.D. Sharma,V.P. Singh 대한토목학회 2008 KSCE JOURNAL OF CIVIL ENGINEERING Vol.12 No.3
In recent years, many hydrology-based approaches have been used to assess the environmental flows in various riversystems over the globe. However, their application has been very limited in India. Brahmani and Baitarani River basins inIndia are two important water surplus basins, in which several water resources projects are coming up shortly. There is anurgent need for the water planners and stakeholders to assess best management practices of available water resources. The present paper (i) critically evaluates the applicability of existingapproaches, (ii) provides values of environmental design flows at different locations of Brahmani and Baitarani River systems,and (iii)suggest a suitable scientific approach for the assessment of environmental flows.
Comparison of Different Techniques for Measurement of Cold Work in Mild Steel
Badgujar, B. P.,Jha, S. K.,Goswami, G. L. 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.6
There are various Non-Destructive Evaluation (NDE) techniques used for measurement of residual stresses in material, such as magnetic methods, X-ray diffraction, Ultrasonic velocity measurement etc. The capabilities, applications and limitations of these techniques for evaluation of cold work / plastic deformation were studied and compared. Mild steel plates were subjected to different degree of cold deformation and were analyzed by Magneto-mechanical Acoustic Emission (MAE), Barkhausen Noise (BN) and magnetic properties (hysteresis loop parameters analysis). Further, these specimens were analyzed by X-ray diffraction and ultrasonic velocity measurements. The microhardness measurement and microstructure studies of these cold worked plates were also carried out. The results of all these studies and comparison of different techniques are discussed in this paper.
Corrosion and Nanomechanical Behaviors of 16.3Cr-0.22N-0.43C-1.73Mo Martensitic Stainless Steel
( Rahul Ghosh ),( S. Chenna Krishna ),( A. Venugopal ),( P. Ramesh Narayanan ),( Abhay K. Jha ),( P. Ramkumar ),( P. V. Venkitakrishnan ) 한국부식방식학회(구 한국부식학회) 2016 Corrosion Science and Technology Vol.15 No.6
The effect of nitrogen on the electrochemical corrosion and nanomechanical behaviors of martensitic stainless steel was examined using potentiodynamic polarization and nanoindentation test methods. The results indicate that partial replacement of carbon with nitrogen effectively improved the passivation and pitting corrosion resistance of conventional high-carbon and high- chromium martensitic steels. Post-test observation of the samples after a potentiodynamic test revealed a severe pitting attacks in conventional martensitic steel compared with nitrogen- containing martensitic stainless steel. This was shown to be due to (i) microstructural refinement results in retaining a high-chromium content in the matrix, and (ii) the presence of reversed austenite formed during the tempering process. Since nitrogen addition also resulted in the formation of a Cr<sub>2</sub>N phase as a process of secondary hardening, the hardness of the nitrogen- containing steel is slightly higher than the conventional martensitic stainless steel under tempered conditions, even though the carbon content is lowered. The added nitrogen also improved the wear resistance of the steel as the critical load (Lc2) is less, along with a lower scratch friction coefficient (SFC) when compared to conventional martensitic stainless steel such as AISI 440C.