http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Otsuki Shuhei,Ikeda Kuniaki,Wakama Hitoshi,Okuno Nobuhiro,Okamoto Yoshinori,Okayoshi Tomohiro,Miyamoto Yuki,Neo Masashi 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-
The purpose of the study was to determine the effect of cartilage degeneration at the patellofemoral joint on clinical outcomes after open wedge high tibial osteotomy and to investigate the predisposing factors for progressive patellofemoral cartilage degeneration.Seventy-two knees were evaluated on second-look arthroscopy in patients who opted for plate and screw removal at an average of 20.1 months after osteotomy. Cartilage degeneration at the patellofemoral joint was evaluated using the International Cartilage Repair Society grading system, with cases divided into progression and nonprogression groups. Radiographic parameters of the patellofemoral anatomy, knee range of motion, and clinical outcomes were evaluated from the preoperative baseline to the final follow up, on average 50 months after osteotomy. A contracture > 5° was considered a flexion contracture. Cartilage degeneration progressed in 31 knees, and preoperative knee flexion contracture was significantly associated with progressive degeneration ( P < 0.01). The Lysholm and Kujala scores were significantly lower in the progression group (87.9 and 85.3, respectively) than in the nonprogression group (91.6 and 93.6, respectively) ( P < 0.05). The odds ratio of the flexion contracture resulting in progression of patellofemoral cartilage degeneration was 4.63 (95% confidence interval, 1.77–12.1). No association was detected between progressive degeneration and age, sex, body mass index, Kellgren-Lawrence grade, or radiographic parameters. Flexion contracture may be associated with progression of cartilage degeneration at the patellofemoral joint and may negatively affect the clinical outcomes after open wedge, high tibial osteotomy.
Cis-element architecture of Nrf3–sMaf heterodimer binding sites and its relation to diseases
Akihito Otsuki,Masayuki Yamamoto 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.3
Cellular detoxication is essential for healthbecause it provides protection against various chemicalsand xenobiotics. The KEAP1–NRF2 system is important forcellular defense against oxidative and electrophilic stressesas NRF2 activates the transcription of an array of cytoprotectivegenes, including drug-metabolizing and antioxidantenzymes, in a stress-dependent manner. The CNC family oftranscription factors, including NRF2, form heterodimerswith small Maf (sMaf) proteins and bind to consensus DNAsequences that have been referred to as antioxidant responseelement, electrophile response element, or NF-E2-bindingelement. These sequences are now collectively called CNC–sMaf binding element (CsMBE). In addition to forming aheterodimer with CNC proteins, sMaf proteins can formhomodimers and recognize regulatory motifs called Maf recognitionelement (MARE). Although the CsMBE sequencesubstantially overlaps with that of MARE, the sequencesdiffer. NRF2 selectively recognizes CsMBE, which is criticalfor cytoprotection. Recent advances in high-throughputsequencing and population-scale genome analysis providenew insights into the transcriptional regulation involved inthe stress response. The integration of a genome-wide mapof NRF2 occupancy with disease-susceptibility loci revealsthe associations between polymorphisms in CsMBE and diseaserisk, information useful for the personalized medicineof the future.
Satoshi Otsuki 한국유체기계학회 2022 International journal of fluid machinery and syste Vol.15 No.1
Generally the boundary layer loss is recognized as the main loss in the cascade flow in actual turbomachinery. Therefore, the loss in the other area outside the boundary layer which we call a mid-flow was often neglected. However, in the present paper, the mid-flow loss evaluation is conducted again to verify if it can really be neglected with all conditions. As a result, it is surely verified that the mid-flow loss can be negligible with higher pressure conditions. However, with lower pressure conditions, it is verified that the mid-flow loss can occupy several tens of % of the total loss; therefore, it cannot be neglected and it is effective to reduce the total loss by reducing the mid-flow loss with these conditions. Moreover, it is verified that the mid-flow loss has the characteristic in which it is inversely proportional to the chord for the identical solidity cascade flow; therefore, it is verified that wide chord cascade can reduce the mid-flow loss. Hence, the wide chord cascade can reduce the total loss in actual turbomachinery.
Development of BrushDevice Facilitating Painting Operation in 2D/3D Space
Mai Otsuki,Masashi Tsukadaira,Asako Kimura,Fumihisa Shibata,Hideyuki Tamura 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
We have proposed a set of devices for various manipulations in spatial works. The devices use a metaphor of existing tools which are familiar in everyday life. Such tools have good affordance, and at the same time, every user already has a mental model for their operation. We believe that such advantages not only lead users to the correct operation, but provide an intuitive operation. Initially, we realized TweezersDevice for pick-and-move manipulation in the spatial works. Now, we have developed BrushDevice for painting in 2D/3D space. This paper describes the design, mechanism, prototype, pilot test, and findings.
Synthetic Study of Carbohydrate Binding Domain of Siglec7
Akihisa Otsuki,Ryo Okamoto,Masayuki Izumi,Yasuhiro Kajihara 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Sialic acid-binding immunoglobulin-like lectin (Siglec) 7 is one of the sialic acid binding protein that plays an important role in immune system. Siglec 7 is expressed on natural killer cells and displays a unique ligand binding properties comparing to the other members of the Siglec family, specifically binds to 2,8-disialyl residues. The precise structural analysis of Siglec 7 has been already performed, and amino acid residues involved in the ligand binding are reported. In such context, we set out the first total chemical synthesis of Siglec 7 carbohydrate binding domain (CBD) which consists of 127 amino acid residues. Since chemical synthesis can easily introduce unnatural amino acids, we envisioned that we could produce an artificial sialic acid binding lectin based on this chemical synthetic strategy. The synthesis of Siglec 7 CBD was carried out by convergent total chemical synthesis. The whole polypeptide was assembled from 5 peptide segments (Figure), which were synthesized by conventional solid phase peptide synthesis. We applied native chemical ligation (NCL) for the coupling of these segments sequentially from C-terminus, combined with alkylation with haloacetoamide or desulfuration reaction. These reactions can provide pseudo-Gln residue or Ala residue from Cys residues at the ligation sites. Based on these strategies we have successfully obtained the full-length polypeptide of Siglec 7 CBD and currently are investigating the in vitro folding step.
Boundary Layer Loss Reduction of Cascade Flow by Wide Chord
Satoshi Otsuki 한국유체기계학회 2021 International journal of fluid machinery and syste Vol.14 No.2
In actual turbomachinery, the wider chord cascade sometimes shows a higher aerodynamic efficiency than the shorter chord one. This study tries to ascertain the underlying physical mechanism of the wide chord advantage mentioned above in terms of the boundary layer loss reduction. It is verified the boundary layer loss has the characteristics of the chord to the power of -1/n ( n > 1), therefore, the wide chord can reduce it. Next, by CFD, it is verified the boundary layer loss is surely reduced by the wide chord. Consequently it is verified the wide chord is effective to reduce the viscous loss in actual turbomachinery.