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Kim, Minji,Furuzono, Tomoya,Yamakuni, Kanae,Li, Yongjia,Kim, Young-Il,Takahashi, Haruya,Ohue-Kitano, Ryuji,Jheng, Huei-Fen,Takahashi, Nobuyuki,Kano, Yuriko,Yu, Rina,Kishino, Shigenobu,Ogawa, Jun,Uchid The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.11
<P>Gutmicrobiota can regulate the host energymetabolism; however, the underlying mechanisms that could involve gut microbiota-derived compounds remain to be understood. Therefore, in this study, we investigated the effects ofKetoA [10-oxo-12(Z)-octadecenoic acid]-a linoleic acidmetaboliteproduced by gut lactic acid bacteria-on whole-body energy metabolism and found that dietary intake of KetoA could enhance energy expenditure in mice, thereby protecting mice from diet-induced obesity. By using Ca2+ imaging and whole-cell patch-clamp methods, KetoA was noted to potently activate transient receptor potential vanilloid 1 (TRPV1) and enhance noradrenalin turnover in adipose tissues. In addition, KetoA up-regulated genes that are related to brown adipocyte functions, including uncoupling protein 1 (UCP1) inwhite adipose tissue (WAT), whichwas later diminished in the presence of a b-adrenoreceptor blocker. By using obese and diabetic model KK-Ay mice, we further show that KetoA intake ameliorated obesity-associatedmetabolic disorders. In the absence of any observedKetoA-induced antiobesity effect or UCP1 up-regulation in TRPV1-deficient mice, we prove that the antiobesity effect of KetoAwas caused by TRPV1 activation-mediated browning inWAT. KetoA produced in the gut could therefore be involved in the regulation of host energy metabolism.-Kim, M., Furuzono, T., Yamakuni, K., Li, Y., Kim, Y.-I., Takahashi, H., Ohue-Kitano, R., Jheng, H.-F., Takahashi, N., Kano, Y., Yu, R., Kishino, S., Ogawa, J., Uchida, K., Yamazaki, J., Tominaga, M., Kawada, T., Goto, T. 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1.</P>
( Nobuyuki Hiraoka ),( Shuji Nakagawa ),( Eigo Otakara ),( Hiroaki Inoue ),( Kenji Takahashi ),( Yuji Arai ) 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-
Background: Hybrid closed-wedge high tibial osteotomy (hybrid CWHTO) is an effective surgical treatment for medial compartment osteoarthritis of the knee. Our study investigated whether the combination of a lateral locking plate and a single medial screw promoted bone union after hybrid CWHTO. Methods: The study cohort consisted of 30 patients (15 men and 15 women) who underwent hybrid CWHTO for medial compartment osteoarthritis or spontaneous osteonecrosis of the knee. Sixteen knees were fixed with a lateral locking plate (LP group), and 17 were fixed with both a lateral locking plate and a cannulated cancellous screw on the medial side of the tibia (LPS group). The times to bone union, radiolucency, and callus formation at the osteotomy site were evaluated radiographically. Results: The mean postoperative time to radiographic confirmation of bone union was 5.5 ± 2.6 months in the LP group and 3.4 ± 1.5 months in the LPS group. Radiolucency at the osteotomy site and excess callus formation on the posterior side of the tibia were lower in the LPS group than in the LP group. Conclusions: This modified hybrid CWHTO combining a lateral locking plate and a cannulated cancellous screw on the medial side of the tibia improves the stability of the osteotomy site and shortens the period of bone union.
( Nobuyuki Hiraoka ),( Shuji Nakagawa ),( Eigo Otakara ),( Hiroaki Inoue ),( Kenji Takahashi ),( Yuji Arai ) 대한슬관절학회 2021 대한슬관절학회지 Vol.33 No.-
Background: Hybrid closed-wedge high tibial osteotomy (hybrid CWHTO) is an effective surgical treatment for medial compartment osteoarthritis of the knee. Our study investigated whether the combination of a lateral locking plate and a single medial screw promoted bone union after hybrid CWHTO. Methods: The study cohort consisted of 30 patients (15 men and 15 women) who underwent hybrid CWHTO for medial compartment osteoarthritis or spontaneous osteonecrosis of the knee. Sixteen knees were fixed with a lateral locking plate (LP group), and 17 were fixed with both a lateral locking plate and a cannulated cancellous screw on the medial side of the tibia (LPS group). The times to bone union, radiolucency, and callus formation at the osteotomy site were evaluated radiographically. Results: The mean postoperative time to radiographic confirmation of bone union was 5.5 ± 2.6 months in the LP group and 3.4 ± 1.5 months in the LPS group. Radiolucency at the osteotomy site and excess callus formation on the posterior side of the tibia were lower in the LPS group than in the LP group. Conclusions: This modified hybrid CWHTO combining a lateral locking plate and a cannulated cancellous screw on the medial side of the tibia improves the stability of the osteotomy site and shortens the period of bone union.
Large Eddy Simulation of turbulent combustion flows in gas-turbine combustors
Nobuyuki Oshima,Yusuke Takahashi 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.11
This research investigates turbulent combustion model based on a multiple-scalar flamelet approach coupling the two concepts of premixed and non-premixed and non-premixed flames expressed by the conservative scalar of mixture fraction and the levelset function(G-equation) of premixed flame front, respectively. A new conceptual G-equation is developed for capturing the complicated non-premixed flame propagation, which can directly model not only the flame speed and also the flame thickness. For applying to real scale gas-turbine combustor, the large eddy simulation (LES) is introduced to simulate the unsteady phenomena of turbulent combustion. The new flamelet model can be applied in the unsteady simulation on the practical unstructured grid system without any additional numerical viscosity or re-initialization treatment. Industrial applications to different types of gas-turbine combustors are introduced. In any case, premixed or partial premixed turbulent flames by the complex burner system of industrial combustor can be reasonably captured by the new flamelet approach without any additional numerical procedure or artificial diffusive scheme.
Yoshitaka Takahashi,Nobuyuki Shimizu,Kohei Suzuki 대한기계학회 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.1S
Accurate seismic analyses of large deformable moving structures are still unsolved problems In the field of earthquake engineering In order to analyze these problems, the nonlinear finite element method formulated by the absolute nodal coordinate approach is noticed Because, this formulation has several advantages over the standard procedures on mass matrix, elastic forces and damping forces In the case of large displacement problems But, It has not been fully studied to build frame structure models by using beam elements In the absolute nodal coordinate formulation In this paper, we propose the connecting method of the beam elements formulated by the absolute nodal coordinate The coordinate transformation matrix of this element is Introduced into the frame structure This beam element has the characteristic that the mass matrix and bending stiffiness matrix are constant even If m the case of large displacement problems, and this characteristic is being kept after the transformation In order to verify the proposed method, we show the numerical simulation results of frame structures for a vibration problem and a large displacement problem<br/>
Toshikazu Sekine,Nobuyuki Ichimura,Yasuhiro Takahashi,Kunikatsu Kobayashi 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
A simple wave absorber with specified reflection and transmission coefficients at both sides is proposed. This wave absorber consists of two transparent dielectric layers with three transparent resistance films. This wave absorber is transparent and electromagnetic waves are absorbed in both sides. Then it is suitable for the indoor use as electromagnetic wave separater.
Toshiyuki Irie,Nobuyuki Takahashi,Sodai Hoshiai 소화기인터벤션의학회 2020 Gastrointestinal Intervention Vol.9 No.1
Super-selective lipiodol balloon-occluded transarterial chemoembolization (SSLB-TACE) increases lipiodol accumulation in the targeted nodule. To understand the mechanism of increased accumulation, it is necessary to understand intra-hepatic collateral system and rheology of lipiodol. Although SSLB-TACE is thought to be a promising technique, randomized prospective controlled trials to compare local control rates with conventional super-selective lipiodol (c-TACE) are still lacking. Another problem for SSLB-TACE is change of TACE candidates by development of radiofrequency ablation (RFA) technology. Patients with limited number of small nodules are good candidates for both SSLB-TACE and c-TACE, but these are also good candidates for RFA. Because higher priority is given to RFA, TACE is usually indicated for patients with 4 or more nodules, with large nodule(s), and/or with proximal Glisson attaching nodule(s). However, these cases are known as TACE-refractory, and the chance to perform SSLB-TACE or c-TACE would be markedly decreased in institutions where RFA is aggressively performed. In the past, paradigm shift from non-selective TACE to super-selective TACE occurred, and the goal of SSLB-TACE and c-TACE is prolonged complete remission of the treated nodules while sacrificing small volume of liver parenchyma. But another TACE technique, aiming treatment of wide region (hemi-lobe or more) and effective tumor volume reduction while minimizing liver parenchymal damage, is mandatory in RFA era. For this purpose, we developed a new balloon-occluded TACE without using lipiodol; alternate infusion of cisplatin solution and sparse gelatin slurry was repeated under balloon-occlusion (RAIB-TACE) until stasis of gelatin slurry in proximal hepatic arteries was seen. However, not only RFA but also recent development of molecular targeted drugs strongly influences on the indication and the aim of TACE. The goal and technique of TACE should be properly selected in each era, in each institution, and for each patient.