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Chao Lin,Xue-Song Sun,Sai-Lan Liu,Xiao-Yun Li,Nian Lu,Xin-Ling Li,Lin-Quan Tang,Ling Guo 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose The prognosis of nasopharyngeal carcinoma (NPC) patients with parotid lymph node (PLN) metastasis remains unclear. This study was performed to investigate the prognostic significance and optimal staging category of PLN metastasis and develop a nomogram for estimating individual risk. Materials and Methods Clinical data of 7,084 non-metastatic NPC patients were retrospectively reviewed. Overall survival (OS) was the primary endpoint. A nomogram was established based on the Cox proportional hazards regression model. The accuracy and calibration ability of this nomogram was evaluated by C-index and calibration curves with bootstrap validation. Results Totally, 164/7,084 NPC patients (2.3%) presented with PLNs. Multivariate analyses showed that PLN metastasis was a negative prognostic factor for OS, progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS). Patients with PLN metastasis had a worse prognosis than N3 disease. Five independent prognostic factors were included in the nomogram, which showed a C-index of 0.743. The calibration curves for probability of 3- and 5-year OS indicated satisfactory agreement between nomogram-based prediction and actual observation. All results were confirmed in the validation cohort. Conclusion NPC patient with PLN metastasis had poorer survival outcome (OS, PFS, DMFS, and LRFS) than N3 disease. We developed a nomogram to provide individual prediction of OS for patients with PLN metastasis.
Analysis and Implementation of a New Three-Level Converter
Lin, Bor-Ren,Nian, Yu-Bin The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.3
This study presents a new interleaved three-level zero-voltage switching (ZVS) converter for high-voltage and high-current applications. Two circuit cells are operated with interleaved pulse-width modulation in the proposed converter to reduce the current ripple at the input and output sides, as well as to decrease the current rating of output inductors for high-load-current applications. Each circuit cell includes one half-bridge converter and one three-level converter at the primary side. At the secondary side, the transformer windings of two converters are connected in series to reduce the size of the output inductor or switching current in the output capacitor. Based on the three-level circuit topology, the voltage stress of power switches is clamped at $V_{in}/2$. Thus, MOSFETs with 500 V voltage rating can be used at 800 V input voltage converters. The output capacitance of the power switch and the leakage inductance (or external inductance) are resonant at the transition interval. Therefore, power switches can be turned on under ZVS. Finally, experiments verify the effectiveness of the proposed converter.
( Liangbo Lin ),( Quanhe Qiu ),( Nian Zhou ),( Wen Dong ),( Jieliang Shen ),( Wei Jiang ),( Ji Fang ),( Jie Hao ),( Zhenming Hu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.3
Bone morphogenetic protein 9 (BMP9) is a potent inducer of osteogenic differentiation of mesenchymal stem cells. The Wnt antagonist Dickkopf-1 (Dkk1) is involved in skeletal development and bone remodeling. Here, we investigated the role of Dkk1 in BMP9-induced osteogenic differentiation of MSCs. We found that overexpression of BMP9 induced Dkk1 expression in a dose-dependent manner, which was reduced by the P38 inhibitor SB203580 but not the ERK inhibitor PD98059. Moreover, Dkk1 dramatically decreased not only BMP9-induced alkaline phosphatase (ALP) activity but also the expression of osteocalcin (OCN) and osteopontin (OPN) and matrix mineralization of C3H10T1/2 cells. Furthermore, exogenous Dkk1 expression inhibited Wnt/β-catenin signaling induced by BMP9. Our findings indicate that Dkk1 negatively regulates BMP9-induced osteogenic differentiation through inhibition of the Wnt/β-catenin pathway and it could be used to optimize the therapeutic use of BMP9 and for bone tissue engineering. [BMB Reports 2016; 49(3): 179-184]
Zu-Chun Lin,Hsin-Ling Hsieh,Wen-Ting Chang,Nian-An Liu,Li-Ren Chen 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim(s): Design Thinking is a human-centered problem-solving solution. It seeks innovative solutions for different issues by starting from human needs. The process includes empathizing, defining, ideating, prototyping, and testing. Innovation is a new trend for nursing education and talent training, but nursing-related research that combines design thinking with innovative research and development is lacking. In this study, cross-disciplinary instructors used design thinking to lead a team of nursing students in innovating on a Pre-loaded Diluent and Medication Syringe. The completed pilot test provides implementation and research directions for innovation education. Method(s): The researchers created 15 questions regarding ease of operation, safe use, environmental friendliness, and economic benefits for their self-developed Pre-loaded Diluent and Medication Syringe. The research team then demonstrated the device to 40 invited nursing students with registered nurse licenses, who were then asked to complete the questionnaire, thus allowing score-based comparisons between this innovative syringe and traditional syringes used in drug administration. The data was analyzed using descriptive and inferential statistics. Result(s): The results of the research showed that there was no significant difference on the “applicable to all types of wards” question for ease of operation, but the other 14 items all showed significant differences (P<.05). The reason for that insignificant difference may be due to unmet needs for micro-administration of special drugs and reuse of pediatric surplus; this prompted the research team to carry out develop on a Drug-mixing Syringe Feasible for Multiple Administrations. Conclusion(s): Based on the evaluation results, the research team developed a syringe more optimized to meet clinical needs. The study provides cross-disciplinary guidance to students in the process of nursing innovation, and narrows research gaps in related fields.
Analysis and Implementation of a New Three-Level Converter
Bor-Ren Lin,Yu-Bin Nian 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.3
This study presents a new interleaved three-level zero-voltage switching (ZVS) converter for high-voltage and high-current applications. Two circuit cells are operated with interleaved pulse-width modulation in the proposed converter to reduce the current ripple at the input and output sides, as well as to decrease the current rating of output inductors for high-load-current applications. Each circuit cell includes one half-bridge converter and one three-level converter at the primary side. At the secondary side, the transformer windings of two converters are connected in series to reduce the size of the output inductor or switching current in the output capacitor. Based on the three-level circuit topology, the voltage stress of power switches is clamped at Vin/2. Thus, MOSFETs with 500 V voltage rating can be used at 800 V input voltage converters. The output capacitance of the power switch and the leakage inductance (or external inductance) are resonant at the transition interval. Therefore, power switches can be turned on under ZVS. Finally, experiments verify the effectiveness of the proposed converter.
Yang, Gongde,Fu, Xinghe,Lin, Mingyao,Li, Nian,Li, Hao The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.1
This research comparatively studies three kinds of flux regulation methods, namely, stored capacitor discharge pulse (SCDP), constant current source pulse (CCSP), and quantitative flux regulation pulse (QFRP), which are used for hybrid permanent magnet (PM) axial field flux-switching memory machines (HPM-AFFSMMs). Through an analysis of the operation principle and the series hybrid PM flux regulation mechanism of the objective machine, the circuit topologies and flux regulation process of these flux regulation methods are addressed in detail. On the basis of a simulation, the flux regulation characteristics of the researched machine during the magnetization and demagnetization processes are comparatively evaluated. Then, machine performance, including back EMF, direct and quadrature axis inductances, and magnetization and demagnetization characteristics, is quantitatively investigated. Results show that the QFRP enables the HPM-AFFSMM to achieve a less harmonic component of back EMF by approximately 7.28% and 7.97% at the magnetization and demagnetization states, respectively, and a more complete magnetization process than the SCDP and CCSP.
Gong-De Yang,Xinghe Fu,Mingyao Lin,Nian Li,Hao Liu 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.1
This research comparatively studies three kinds of flux regulation methods, namely, stored capacitor discharge pulse (SCDP),constant current source pulse (CCSP), and quantitative flux regulation pulse (QFRP), which are used for hybrid permanentmagnet (PM) axial field flux-switching memory machines (HPM-AFFSMMs). Through an analysis of the operation principleand the series hybrid PM flux regulation mechanism of the objective machine, the circuit topologies and flux regulation processof these flux regulation methods are addressed in detail. On the basis of a simulation, the flux regulation characteristics of theresearched machine during the magnetization and demagnetization processes are comparatively evaluated. Then, machineperformance, including back EMF, direct and quadrature axis inductances, and magnetization and demagnetizationcharacteristics, is quantitatively investigated. Results show that the QFRP enables the HPM-AFFSMM to achieve a lessharmonic component of back EMF by approximately 7.28% and 7.97% at the magnetization and demagnetization states,respectively, and a more complete magnetization process than the SCDP and CCSP.