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Nguyen Ngoc Minh,Duong Men Thi Hoai,Nguyen Phuong Linh,Bui Bich Phuong,Ahn Hee-Chul,Cho Jungsook 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.5
Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential inhibitor of c-Jun N-terminal kinase 3 (JNK3). Although its antihypertensive effect is widely known, the role of efonidipine in the central nervous system has remained elusive. The present study investigated the effects of efonidipine on the inflammation and cell migration induced by lipopolysaccharide (LPS) using murine BV2 and human HMC3 microglial cell lines and elucidated signaling molecules mediating its effects. We found that the phosphorylations of JNK and its downstream molecule c-Jun in LPS-treated BV2 cells were declined by efonidipine, confirming the finding from virtual screening. In addition, efonidipine inhibited the LPS-induced production of pro-inflammatory factors, including interleukin-1β (IL-1β) and nitric oxide. Similarly, the IL-1β production in LPS-treated HMC3 cells was also inhibited by efonidipine. Efonidipine markedly impeded cell migration stimulated by LPS in both cells. Furthermore, it inhibited the phosphorylation of inhibitor kappa B, thereby suppressing nuclear translocation of nuclear factor-κB (NF-κB) in LPS-treated BV2 cells. Taken together, efonidipine exerts anti-inflammatory and anti-migratory effects in LPS-treated microglial cells through inhibition of the JNK/NF-κB pathway. These findings imply that efonidipine may be a potential candidate for drug repositioning, with beneficial impacts on brain disorders associated with neuroinflammation.
Dual-hop Relaying Networks for Short-Packet URLLCs: Performance analysis and Optimization
Nguyen Thi Yen Linh,Ngo Hoang Tu,Pham Ngoc Son,Vo Nguyen Quoc Bao 한국통신학회 2022 Journal of communications and networks Vol.24 No.4
This paper investigates short-packet communications for the dual-hop decode-and-forward relaying system to facilitate ultra-reliable and low-latency communications. In this system, based on the transmit antenna selection and partial relay selection techniques, a selected relay having the highest received signal-to- noise ratio (SNR) serves as a forwarder to support the unavailable direct link between the source and destination, whereas a max- imum ratio combining technique is leveraged at the destination to achieve the highest diversity gain. Approximated expressions of end-to-end (e2e) block error rates (BLERs) are derived over quasi-static Rayleigh fading channels and the finite-blocklength regime. To gain more insights about the performance behavior in the high-SNR regime, we provide the asymptotic analysis with two approaches, from which the qualitative conclusion based on the di- versity order is made. Furthermore, the power allocation and relay location optimization problems are also considered to minimize the asymptotic e2e BLER under the configuration constraints. Our analysis is verified through Monte-Carlo simulations, which yield the system parameters’ impact on the system performance.
EVOLUTION OF STRUCTURE OF LIQUID AND AMORPHOUS Al2O3·2SiO2 NANOPARTICLES UPON COOLING FROM THE MELTS
NGUYEN NGOC LINH,VO VAN HOANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.4
Structural properties of liquid and amorphous Al2O3·2SiO2 nanoparticles have been investigated by molecular dynamics (MD) method. The simulations were done in a spherical model with different sizes of 2 nm, 3 nm and 4 nm under nonperiodic boundary conditions. We use the Born–Mayer type interatomic potentials. We determined the changes in mean interatomic distances, coordination number distributions, partial radial distribution functions (PRDFs) and bond-angle distributions of Al2O3·2SiO2 nanoparticles upon cooling towards glassy state. Calculations show that liquid and amorphous Al2O3·2SiO2 nanoparticles have a slightly distorted tetrahedral network structure with the mean coordination number ZAl - O ≈ 4.0 and ZSi - O ≈ 4.0, which is contrary to that of the liquid and amorphous bulk. Temperature dependence of structural defects in nanoparticles was found and discussed. In addition, we found size effects on glass transition temperature of Al2O3·2SiO2 nanoparticles in that it decreases with decreasing size.
Ngoc Nhon Hoang,Tri Khoi Nguyen,Tuyet Hoa Vo,Ngoc Hoi Nguyen,Dai Hai Nguyen,Dieu Linh Tran 한국고분자학회 2022 Macromolecular Research Vol.30 No.2
Fucoidan, a natural sulfated polysaccharide extracted from seaweed, has been widely used in pharmaceutical field due to its excellent biological activities including antiviral, anticancer, antioxidant, anticoagulant, etc. Therefore, investigating the new natural sources of fucoidan has been received growing attention recently. This study reported for the first time the isolation, purification, characterization, and biological activities of fucoidan from Ceratophyllum submersum (FCS). The molecular weight of obtained FCS was 9.7 kDa, composed of fucose (42.11%) and sulfate (16.38%). The FCS contained (1→3)-α-L-Fucopyranose and β-D-galactose bond in the structure. In addition, FCS showed strong antioxidant properties against 2,2-diphenyl-1-picrylhydrazyl, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid), and reactive oxygen species radicals with inhibitory concentration 50 values were 765.48 ppm, 845.31 ppm, and 1760.00 ppm, respectively. The FCS also performed good antibacterial, antifungal, anticoagulant and anti-inflammatory activityies. Especially, it expressed a better inhibition activity on breast cancer cell line (MCF-7) than that on liver cancer cells (HepG2), lung cancer cells (NCI-H460), and cervical cancer cells (HeLa). FCS demonstrated potential utility in functional food, cosmeceutical, and pharmaceutical industries. In the trend of discovering new sources for fucoidan with outstanding bioactivities, this report would contribute a basic platform and valuable information for further studies on fucoidan from C. Submersum.
Nguyen, Thanh Huong,Nguyen, Trung Kien,Kim, Bao Giang,Hoang, Van Minh,Phan, Thi Hai,Doan, Thu Huyen,Luong, Ngoc Khue,Nguyen, Thuy Linh,Nguyen, Tuan Lam,Pham, Thi Quynh Nga Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1
Studies have shown that smoking is a learnt behavior, often initiated during adolescence. This paper aims to describe tobacco-related knowledge, attitude and associations among school adolescents aged 13-15 with exposure to anti-smoking information. Using data from the Global Youth Tobacco Survey (GYTS) in Viet Nam, 2014, knowledge was measured through 4 questions about tobacco use, and attitude was assessed through 3 questions on personal, social and environmental aspects. Students giving most anti-tobacco responses to all questions were considered as having correct knowledge or appropriate attitude or both. Access to anti-smoking information was determined by exposure to any media messages on tobacco control during the past 30 days and teaching in school about the danger of tobacco use during the past 12 months. A substantial percentage of students thought that being near others who smoke might be harmful to them and smoking is harmful to health (89.4% and 89.6% respectively). However, only 46.4% reported that it is definitely difficult to quit smoking and 66.9% thought that smoking for only 1 or 2 years, once stopped, is harmful to health. Slightly more than half of the respondents reported appropriate attitude that young smokers have fewer friends than others and smoking makes them less attractive and less comfortable at social events. Noticing anti-smoking messages in the media together with having lessons in school about the dangers of tobacco substantially increased the likelihood of having correct knowledge, appropriate attitude and both. Despite relatively high awareness about smoking harms, effective educational communication is still highly needed to improve the level of comprehensive knowledge and an appropriate attitude regarding tobacco use.
Analysis of thin-walled beam-shell structures for concept modeling based on higher-order beam theory
Nguyen, Ngoc-Linh,Jang, Gang-Won,Choi, Soomin,Kim, Jaeyong,Kim, Yoon Young Elsevier 2018 Computers & structures Vol.195 No.-
<P><B>Abstract</B></P> <P>Many engineering structures consist of thin-walled beams and shells. Especially for fast design in an early design stage, a simplified analysis using beams for load-carrying members and shells for panels is very useful, but there appears no accurate beam-shell combined finite element model. The main reason is that the Timoshenko or Euler beam elements are incapable of representing significant sectional deformations near beam joints or near beam-panel interfaces. Although some progress has been made in developing higher-order beam elements that can accurately capture the sectional deformations, there is no investigation to develop higher-order beam and shell combined models useful to analyze various engineering structures. The main contribution of this work is to present the first attempt to model structures made of thin-walled closed beams and shells in terms of higher-order beam elements and shell elements and to establish the matching conditions between the dissimilar field variables of higher-order beam and shell elements along their interfaces. For the finite element analysis of a whole structure, the interface matching conditions are imposed through Lagrange multipliers. High accuracy of the proposed higher-order beam-shell method is demonstrated through static and modal analyses of various structures including a simplified model of a vehicle body-in-white (BIW).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Field variable matching between higher-order beam elements and shell elements is presented. </LI> <LI> Proposed models accurately predict higher-order cross section deformations and joint stiffness. </LI> <LI> The proposed method can be applied to simplified beam models such as vehicle bodies-in-white. </LI> </UL> </P>