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Park, Won Sun,Ko, Jae-Hong,Ko, Eun A,Son, Youn Kyoung,Hong, Da Hye,Jung, In Duk,Park, Yeong-Min,Choi, Tae-Hoon,Kim, Nari,Han, Jin The Japanese Pharmacological Society 2010 JOURNAL OF PHARMACOLOGICAL SCIENCES Vol.112 No.1
<P>We investigated the effects of YC-1, an activator of soluble guanylyl cyclase (sGC), on voltage-dependent K<SUP>+</SUP> (Kv) channels in smooth muscle cells from freshly isolated rabbit coronary arteries by using the whole-cell patch clamp technique. YC-1 inhibited the Kv current in a dose-dependent fashion with an apparent <I>K</I><SUB>d</SUB> of 9.67 <I>μ</I>M. It accelerated the decay rate of Kv channel inactivation without altering the kinetics of current activation. The rate constants of association and dissociation for YC-1 were 0.36 ± 0.01 <I>μ</I>M<SUP>−1</SUP>·s<SUP>−1</SUP> and 3.44 ± 0.22 s<SUP>−1</SUP>, respectively. YC-1 did not have a significant effect on the steady-state activation and inactivation curves. The recovery time constant from inactivation was decreased in the presence of YC-1, and application of train pulses (1 or 2 Hz) caused a progressive increase in the YC-1 blockade, indicating that YC-1–induced inhibition of Kv currents is use-dependent. Pretreatment with Bay 41-2272 (also a sGC activator), ODQ (a sGC inhibitor), or Rp-8-Br-PET-cGMPs (a protein kinase G inhibitor) did not affect the basal Kv current and also did not significantly alter the inhibitory effect of YC-1. From these results, we suggest that YC-1 directly inhibits the Kv current independently of sGC activation and in a state-, time-, and use-dependent fashion.</P>
Park, Jin-Hee,Kim, Hyoung Kyu,Jung, Hana,Kim, Ki Hyang,Kang, Mi Seon,Hong, Jun Hyuk,Yu, Byeng Chul,Park, Sungjae,Seo, Su-Kil,Choi, Il Whan,Kim, Soon Ha,Kim, Nari,Han, Jin,Park, Sae Gwang Spandidos Publications 2017 International journal of oncology Vol.50 No.1
<P>A major goal of breast cancer research is to prevent the molecular events that lead to tumour metastasis. It is well-established that both cytoplasmic and mitochondrial reactive oxygen species (ROS) play important roles in cell migration and metastasis. Accordingly, this study examined the molecular mechanisms of the anti-metastatic effects of NecroX-5, a mitochondrial ROS scavenger. NecroX-5 inhibited lung cancer metastasis by ameliorating migration in a mouse model. In human cancer cells, the inhibition of migration by NecroX-5 is cell type-dependent. We observed that the effect of NecroX-5 correlated with a reduction in mitochondrial ROS, but mitochondrial ROS reduction by MitoQ did not inhibit cell migration. NecroX-5 decreased intracellular calcium concentration by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT down regulation and the reduction of mitochondrial ROS levels. However, the reduction of mitochondrial ROS was not associated with supressed migration and AKT downregulation. Our study demonstrates the potential of NecroX-5 as an inhibitor of breast cancer metastasis.</P>
Nari Shin,Eon Chul Han,Sungho Won,Seung-Bum Ryoo,Eun Kyung Choe,Byung Kwan Park,Kyu Joo Park 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.2
Purpose: The management of patients with colorectal cancer (CRC) who have liver cirrhosis (LC) requires a thorough understanding of both diseases; however, the prognoses and postoperative outcomes of such patients remain understudied. We investigated the effect of LC on surgical and oncologic outcomes in patients with CRC, and identified prognostic factors. Methods: We analyzed 453 patients with CRC and LC (CRC-LC group), 906 with CRC only (CRC group), 906 with LC only (LC group), and 1,812 healthy subjects using health insurance claim data (2008–2013). Results: The CRC-LC group had a higher frequency of intensive care unit admission than the CRC group; there were no differences between the 2 groups in terms of early and late postoperative small bowel obstruction and incisional hernia. However, the 30-day, 60-day, and 90-day mortality rates were all significantly higher in the CRC-LC group. The higher Charlson comorbidity index (hazard ratio [HR], 1.127) and the lower socioeconomic status (HR, 0.985) were significant worse predictors of 5-year survival. Patients with underlying LC had a significantly higher HR in both the advanced CRC (HR, 1.858) and nonadvanced CRC (HR, 1.799) subgroups. However, the nonadvanced CRC subgroup showed a lower HR than the LC group (HR, 0.730). Conclusion: Patients with CRC who had underlying LC had a lower survival rate than did those without LC, although the incidence rates of postoperative complications were not significantly different. The presence of LC was associated with a significantly lower survival rate regardless of CRC presence.
자폐 범주성 장애 아동의 부모 참여 중재 연구 동향 분석
백나리(Park, Nari) 한국자폐학회 2008 자폐성 장애연구 Vol.8 No.2
본 연구는 자폐 범주성 장애 아동의 부모 참여 중재에 관한 국내외 연구들을 분석하여 부모 교육(훈련의 목표 , 부모교육/훈련 환경, 양식, 방법, 내용 요인들을 고찰 하였다.
청년 불안정성의 궤적과 유형: 20대 청년의 고용, 소득, 부채를 중심으로
박나리(Nari Park),김교성(Kyo-seong Kim) 한국사회정책학회 2021 한국사회정책 Vol.28 No.3
본 연구의 목적은 사회구조적 변화에 기인한 청년 불안정성을 개념적으로 정의하고, 그 양상을 실증 분석함으로써 심각해지는 청년 위기를 완화하기 위한 정책 방향을 제시하는 데에 있다. 청년의 불안정성은 ‘청년기에 발생할 수 있는 고용, 소득, 부채와 관련된 안전성(security)이나 안정성(stability)의 결여’로 정의하였다. 청년패널조사(YP2007)에서 만23세~만29세 청년의 자료를 추출하여 병합하고, 고용, 소득, 부채 변수를 활용하여 집단중심다중추세분석을 실시하였다. 청년 불안정성에 대한 7년간의 궤적과 유형을 도출한 결과, 동태적 특성과 집단 내부의 이질성을 포착할 수 있었다. 청년 불안정성의 궤적은 연령에 따른 변화 양상에 따라 상이한 6개 집단으로 분류되었다. 약 12%를 제외한 모든 청년이 일정 수준의 불안정성을 경험하며, 청년의 불안정성은 만23세에서 만28세에 집중되고 있었다. 이러한 결과를 토대로 노동시장 재구조화, 보편적 소득보장, 상보성을 고려한 정책 설계 등을 제안하였다. The purpose of this study is to identify and classify the aspects of youth precariousness based on the longitudinal trajectory to present a policy direction to overcome the youth crisis. Youth precariousness can be defined as ‘a lack of security or stability related to employment, income, and debt that can occur universally among young people’. As a result of a Group-based Multi-trajectory Analysis based on the merging data of young people aged 23 to 29 from the Youth Panel Survey (YP), it was possible to capture the dynamic characteristics of youth precariousness and the heterogeneity within the group. The analysis details are as follows. First of all, the trajectories and typologies of precariousness experienced by young people were classified into 6 different groups according to the changing patterns. All young adults experienced some level of instability, except for about 12%, where all precariousness initially declined to a steady state. In particular, youth precariousness is concentrated from 23 to 28 years of age, and overall instability level is found to ease at the age of 29. Therefore, it is necessary to solve the dual labor market or the institutional dual structure problem in order to cope with the fundamental problem of employment instability. It is also essential to find ways to expand the distribution of youth basic income or capital income as an alternative to the problem of income instability.